PDB: 71589 件ウェブページステータス検索Chemie searchBIRD

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5WFJ	THE JAK3 KINASE DOMAIN IN COMPLEX WITH A COVALENT INHIBITOR 分子名称: 4-({[3-(propanoylamino)phenyl]methyl}amino)pyrrolo[1,2-b]pyridazine-3-carboxamide, Tyrosine-protein kinase JAK3 著者 Sack, J. 登録日 2017-07-12 公開日 2017-10-04 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Discovery of highly potent, selective, covalent inhibitors of JAK3. Bioorg. Med. Chem. Lett., 27, 2017
8BZY	Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation 分子名称: 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide, DIUNDECYL PHOSPHATIDYL CHOLINE, Solute carrier family 40 member 1, ... 著者 Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. 登録日 2022-12-15 公開日 2023-03-22 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife, 12, 2023
8C02	Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation 分子名称: Solute carrier family 40 member 1, Sybody3 著者 Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. 登録日 2022-12-15 公開日 2023-03-22 最終更新日 2023-03-29 実験手法 ELECTRON MICROSCOPY (4.09 Å) 主引用文献 Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife, 12, 2023
8COA	in situ Subtomogram average of Immature Rotavirus TLP spike 分子名称: Intermediate capsid protein VP6, Outer capsid glycoprotein VP7, Outer capsid protein VP4 著者 Shah, P.N.M, Stuart, D.I. 登録日 2023-02-27 公開日 2023-04-05 最終更新日 2023-04-26 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Characterization of the rotavirus assembly pathway in situ using cryoelectron tomography. Cell Host Microbe, 31, 2023
3LAK	Crystal structure of HIV-1 reverse transcriptase in complex with N1-heterocycle pyrimidinedione non-nucleoside inhibitor 分子名称: 3-({3-[(2-amino-6-fluoropyridin-4-yl)methyl]-5-(1-methylethyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl}carbonyl)-5-methylbenzonitrile, CHLORIDE ION, HIV Reverse transcriptase, ... 著者 Lansdon, E.B, Mitchell, M.L. 登録日 2010-01-06 公開日 2010-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg.Med.Chem.Lett., 20, 2010
4Z1Z	Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTCT Central Four 分子名称: CALCIUM ION, DNA (28-MER), GLYCEROL, ... 著者 Hallinan, J.P, Stoddard, B.L. 登録日 2015-03-27 公開日 2016-03-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
4Z20	Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTGT Central Four 分子名称: CALCIUM ION, DNA (26-MER), GLYCEROL, ... 著者 Hallinan, J.P, Stoddard, B.L. 登録日 2015-03-27 公開日 2016-03-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
5WJI	Crystal structure of the F61S mutant of HsNUDT16 分子名称: ACETIC ACID, CHLORIDE ION, SULFATE ION, ... 著者 Thirawatananond, P, Gabelli, S.B. 登録日 2017-07-23 公開日 2018-10-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. Sci Rep, 9, 2019
5WJZ	Cryo-EM structure of B. subtilis flagellar filaments E115G 分子名称: Flagellin 著者 Wang, F, Burrage, A.M, Orlova, A, Kearns, D.B, Egelman, E.H. 登録日 2017-07-24 公開日 2017-10-25 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (5.7 Å) 主引用文献 A structural model of flagellar filament switching across multiple bacterial species. Nat Commun, 8, 2017
3LJ3	PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor 分子名称: (2Z)-4,6-dihydroxy-2-{[1-methyl-4-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methylidene}-1-benzofuran-3(2H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION 著者 Bard, J, Svenson, K. 登録日 2010-01-25 公開日 2010-04-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Bioorg.Med.Chem.Lett., 20, 2010
4YZU	Rapid development of two Factor IXa inhibitors from Hit to Lead 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CHLORIDE ION, Coagulation factor IX, ... 著者 Hruza, A, Reichert, P. 登録日 2015-03-25 公開日 2015-05-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Rapid development of two factor IXa inhibitors from hit to lead. Bioorg.Med.Chem.Lett., 25, 2015
8CDK	CAND1 b-hairpin++-SCF-SKP2 CAND1 partly engaged SCF partly rocked 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2023-01-31 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
5WNR	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus 分子名称: 16S Ribosomal RNA rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... 著者 DeMirci, H. 登録日 2017-08-01 公開日 2018-02-21 最終更新日 2020-10-21 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 2'-O-methylation in mRNA disrupts tRNA decoding during translation elongation. Nat. Struct. Mol. Biol., 25, 2018
8CDJ	CAND1 b-hairpin++-SCF-SKP2 CAND1 rolling SCF engaged 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2023-01-31 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
1NZY	4-CHLOROBENZOYL COENZYME A DEHALOGENASE FROM PSEUDOMONAS SP. STRAIN CBS-3 分子名称: 1,2-ETHANEDIOL, 4-CHLOROBENZOYL COENZYME A DEHALOGENASE, 4-HYDROXYBENZOYL COENZYME A, ... 著者 Benning, M.M, Holden, H.M. 登録日 1996-04-02 公開日 1997-07-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of 4-chlorobenzoyl coenzyme A dehalogenase determined to 1.8 A resolution: an enzyme catalyst generated via adaptive mutation. Biochemistry, 35, 1996
5W8A	The structure of a COA-dependent acyl-homoserine lactone synthase, BjaI, with SAM and isopentyl-CoA 分子名称: Autoinducer synthase, S-ADENOSYLMETHIONINE, isopentyl-Coenzyme A 著者 Dong, S.-H, Nair, S.K. 登録日 2017-06-21 公開日 2017-08-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular basis for the substrate specificity of quorum signal synthases. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3HVK	Rat catechol O-methyltransferase in complex with a catechol-type, purine-containing bisubstrate inhibitor - humanized form 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CHLORIDE ION, Catechol O-methyltransferase, ... 著者 Ehler, A, Schlatter, D, Stihle, M, Benz, J, Rudolph, M.G. 登録日 2009-06-16 公開日 2009-10-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor. Angew.Chem.Int.Ed.Engl., 48, 2009
2XFG	Reassembly and co-crystallization of a family 9 processive endoglucanase from separately expressed GH9 and CBM3c modules 分子名称: CALCIUM ION, CHLORIDE ION, ENDOGLUCANASE 1 著者 Petkun, S, Lamed, R, Jindou, S, Burstein, T, Yaniv, O, Shoham, Y, Shimon, J.W.L, Bayer, E.A, Frolow, F. 登録日 2010-05-24 公開日 2011-06-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.679 Å) 主引用文献 Reassembly and Co-Crystallization of a Family 9 Processive Endoglucanase from its Component Parts: Structural and Functional Significance of Intermodular Linker Peerj, 3, 2015
2Y25	Crystal structure of the myomesin domains My11-My13 分子名称: MYOMESIN 著者 Pinotsis, N, Chatziefthimiou, S.D, Wilmanns, M. 登録日 2010-12-13 公開日 2011-12-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Superhelical Architecture of the Myosin Filament-Linking Protein Myomesin with Unusual Elastic Properties. Plos Biol., 10, 2012
2XUU	Crystal structure of a DAP-kinase 1 mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, DEATH-ASSOCIATED PROTEIN KINASE 1, MAGNESIUM ION, ... 著者 de Diego, I, Kuper, J, Lehmann, F, Wilmanns, M. 登録日 2010-10-21 公開日 2011-11-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A Pef/Y Substrate Recognition and Signature Motif Plays a Critical Role in Dapk-Related Kinase Activity. Chem.Biol., 21, 2014
3HWK	Crystal structure of methylcitrate synthase from Mycobacterium tuberculosis 分子名称: Methylcitrate synthase, SUCCINIC ACID 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2009-06-17 公開日 2009-06-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
1Y6X	The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis 分子名称: Phosphoribosyl-ATP pyrophosphatase 著者 Javid-Majd, F, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2004-12-07 公開日 2005-03-01 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.D, 64, 2008
5ZEC	Crystal structure of Kluyveromyces polyspora ADH (KpADH) mutant (Q136N/F161V/S196G/E214G/S237C) 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ETHANOL, ... 著者 Wang, Y, ZHou, J.Y, Hou, X.D, Xu, G.C, Rao, Y.J, Wu, L, Zhou, J.H, Ni, Y. 登録日 2018-02-27 公開日 2019-01-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.779 Å) 主引用文献 Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones. J. Am. Chem. Soc., 140, 2018
7Y70	RLGSGG-AtPRT6 UBR box (P4332) 分子名称: E3 ubiquitin-protein ligase PRT6, ZINC ION 著者 Kim, L, Song, H.K. 登録日 2022-06-21 公開日 2023-07-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Structural analyses of plant PRT6-UBR box for Cys-Arg/N-degron pathway and insights into the plant submergence resistance To Be Published
7XWD	Apo-AtPRT6 UBR box 分子名称: E3 ubiquitin-protein ligase PRT6, ZINC ION 著者 Kim, L, Song, H.K. 登録日 2022-05-26 公開日 2023-05-31 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.396 Å) 主引用文献 Structural analyses of plant PRT6-UBR box for Cys-Arg/N-degron pathway and insights into the plant submergence resistance To Be Published

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