PDB: 1375 件ウェブページステータス検索Chemie searchBIRD

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4O17	Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors 分子名称: 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION 著者 Oh, A, Coons, M, Brillantes, B, Wang, W. 登録日 2013-12-15 公開日 2014-10-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
4O28	Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors 分子名称: 1,2-ETHANEDIOL, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide, Nicotinamide phosphoribosyltransferase, ... 著者 Oh, A, Coons, M, Brillantes, B, Wang, W. 登録日 2013-12-17 公開日 2014-10-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
4O1A	The crystal structure of the mutant NAMPT G217R 分子名称: 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION 著者 Oh, A, Coons, M, Brillantes, B, Wang, W. 登録日 2013-12-15 公開日 2014-10-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
4O1B	The crystal structure of a mutant NAMPT (G217R) in complex with an inhibitor APO866 分子名称: (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, ... 著者 Oh, A, Coons, M, Brillantes, B, Wang, W. 登録日 2013-12-15 公開日 2014-10-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
4O12	Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase 分子名称: 2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION 著者 Oh, A, Wang, W. 登録日 2013-12-14 公開日 2014-06-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.498 Å) 主引用文献 Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem, 15, 2014
4O1D	Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors 分子名称: (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, ... 著者 Oh, A, Coons, M, Brillantes, B, Wang, W. 登録日 2013-12-15 公開日 2014-10-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.705 Å) 主引用文献 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
1ML0	VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1 分子名称: M3 Protein, Small Inducible Cytokine 著者 Alexander, J.M, Fremont, D.H. 登録日 2002-08-29 公開日 2002-11-13 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Basis of Chemokine Sequestration by a Herpesvirus Decoy Receptor Cell(Cambridge,Mass.), 111, 2002
1N95	Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives 分子名称: 1-[2-(4-CYANO-BENZYLAMINO)-3-(3-METHYL-3H-IMIDAZOL-4-YL)-PROPIONYL]-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ... 著者 Gwaltney II, S.L, O'Conner, S.J, Nelson, L.T, Sullivan, G.M, Imade, H, Wang, W, Hasvold, L, Li, Q, Cohen, J, Gu, W.Z. 登録日 2002-11-22 公開日 2003-01-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives. Bioorg.Med.Chem.Lett., 13, 2003
1NI1	Imidazole and cyanophenyl farnesyl transferase inhibitors 分子名称: 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ... 著者 Tong, Y, Lin, N.H, Wang, L, Hasvold, L, Wang, W, Leonard, N, Li, T, Li, Q, Cohen, J, Gu, W.Z, Zhang, H, Stoll, V, Bauch, J, Marsh, K, Rosenberg, S.H, Sham, H.L. 登録日 2002-12-20 公開日 2004-04-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability. Bioorg.Med.Chem.Lett., 13, 2003
1NL4	Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor 分子名称: 4-[(3-CYANO-BENZYL)-(3-METHYL-3H-IMIDAZOL-4-YLMETHYL)-AMINO]-2-NAPHTHALEN-1-YL-BENZONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ... 著者 Curtin, M.L, Florjancic, A.S, Cohen, J, Gu, W.-J, Frost, D.J, Muchmore, S.W, Sham, H.L. 登録日 2003-01-06 公開日 2003-02-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Novel and Selective Imidazole-containing Biphenyl Inhibitors of Protein Farnesyltransferase BIOORG.MED.CHEM.LETT., 13, 2003
1N94	Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine Derivates 分子名称: 2-{(5-{[BUTYL-(2-CYCLOHEXYL-ETHYL)-AMINO]-METHYL}-2'-METHYL-BIPHENYL-2-CARBONYL)-AMINO]-4-METHYLSULFANYL-BUTYRIC ACID, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ... 著者 Gwaltney II, S.L, O'Connor, S.J, Nelson, L.T, Sullivan, G.M, Imade, H, Wang, W, Hasvold, L, Li, Q, Cohen, J, Gu, W.Z. 登録日 2002-11-22 公開日 2003-01-07 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives. Bioorg.Med.Chem.Lett., 13, 2003
8POE	Structure of tissue-specific lipid scramblase ATG9B homotrimer, refined with C3 symmetry applied 分子名称: Autophagy-related protein 9B 著者 Chiduza, G.N, Pye, V.E, Tooze, S.A, Cherepanov, P. 登録日 2023-07-04 公開日 2023-11-15 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A. Autophagy, 20, 2024
4DN4	Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a 分子名称: ACETATE ION, C-C motif chemokine 2, CNTO888 HEAVY CHAIN, ... 著者 Obmolova, G, Teplyakov, A, Malia, T, Grygiel, T, Sweet, R, Snyder, L, Gilliland, G. 登録日 2012-02-08 公開日 2012-10-03 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888. Mol.Immunol., 51, 2012
1N9A	Farnesyltransferase complex with tetrahydropyridine inhibitors 分子名称: 1-{2-[3-(4-CYANO-BENZYL)-3H-IMIDAZOL-4-YL]-ACETYL}-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ... 著者 Gwaltney II, S.L, O'Conner, S.J, Nelson, L.T, Sullivan, G.M, Imade, H, Wang, W, Hasvold, L, Li, Q, Cohen, J, Gu, W.Z. 登録日 2002-11-22 公開日 2003-01-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency. Bioorg.Med.Chem.Lett., 13, 2003
1QBQ	STRUCTURE OF RAT FARNESYL PROTEIN TRANSFERASE COMPLEXED WITH A CVIM PEPTIDE AND ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID. 分子名称: ACETATE ION, ACETYL-CYS-VAL-ILE-SELENOMET-COOH PEPTIDE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, ... 著者 Strickland, C.L, Windsor, W.T, Syto, R, Wang, L, Bond, R, Wu, Z, Schwartz, J, Le, H.V, Beese, L.S, Weber, P.C. 登録日 1999-04-27 公開日 1999-06-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue Biochemistry, 37, 1998
1AX8	Human obesity protein, leptin 分子名称: OBESITY PROTEIN 著者 Zhang, F, Beals, J.M, Briggs, S.L, Clawson, D.K, Wery, J.-P, Schevitz, R.W. 登録日 1997-10-31 公開日 1998-11-25 最終更新日 2012-05-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of the obese protein leptin-E100. Nature, 387, 1997
6JKJ	Crystal structure of human SPSB2 in the apo-state 分子名称: SPRY domain-containing SOCS box protein 2 著者 Luo, Y, Kuang, Z. 登録日 2019-03-01 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the SPRY domain of human SPSB2 in the apo state. Acta Crystallogr.,Sect.F, 75, 2019
1SEP	MOUSE SEPIAPTERIN REDUCTASE COMPLEXED WITH NADP AND SEPIAPTERIN 分子名称: BIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SEPIAPTERIN REDUCTASE 著者 Auerbach, G, Herrmann, A, Guetlich, M, Fischer, M, Jacob, U, Bacher, A, Huber, R. 登録日 1997-05-23 公開日 1999-01-13 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters. EMBO J., 16, 1997
3ZRT	Crystal structure of human PSD-95 PDZ1-2 分子名称: DISKS LARGE HOMOLOG 4 著者 Sorensen, P.L, Kastrup, J.S, Gajhede, M. 登録日 2011-06-19 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.398 Å) 主引用文献 A High-Affinity, Dimeric Inhibitor of Psd-95 Bivalently Interacts with Pdz1-2 and Protects Against Ischemic Brain Damage. Proc.Natl.Acad.Sci.USA, 109, 2012
1DOK	MONOCYTE CHEMOATTRACTANT PROTEIN 1, P-FORM 分子名称: MONOCYTE CHEMOATTRACTANT PROTEIN 1, SULFATE ION 著者 Lubkowski, J, Bujacz, G, Boque, L, Wlodawer, A, Domaille, P.J, Handel, T.M. 登録日 1996-11-27 公開日 1997-03-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions. Nat.Struct.Biol., 4, 1997
1DOL	MONOCYTE CHEMOATTRACTANT PROTEIN 1, I-FORM 分子名称: MONOCYTE CHEMOATTRACTANT PROTEIN 1 著者 Lubkowski, J, Bujacz, G, Boque, L, Wlodawer, A. 登録日 1996-11-22 公開日 1997-03-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions. Nat.Struct.Biol., 4, 1997
1DON	SOLUTION STRUCTURE OF THE MONOCYTE CHEMOATTRACTANT PROTEIN-1 DIMER USING HETERONUCLEAR, NMR, 20 STRUCTURES 分子名称: MCP-1 著者 Domaille, P.J, Handel, T.M. 登録日 1996-01-21 公開日 1996-10-14 最終更新日 2022-02-16 実験手法 SOLUTION NMR 主引用文献 Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer. Biochemistry, 35, 1996
1DOM	SOLUTION STRUCTURE OF THE MONOCYTE CHEMOATTRACTANT PROTEIN-1 DIMER USING HETERONUCLEAR, NMR, MINIMIZED AVERAGE STRUCTURE 分子名称: MCP-1 著者 Domaille, P.J, Handel, T.M. 登録日 1996-01-21 公開日 1996-10-14 最終更新日 2022-02-16 実験手法 SOLUTION NMR 主引用文献 Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer. Biochemistry, 35, 1996
2ROA	Solution structure of calcium bound soybean calmodulin isoform 4 N-terminal domain 分子名称: CALCIUM ION, Calmodulin 著者 Ishida, H, Huang, H, Yamniuk, A.P, Takaya, Y, Vogel, H.J. 登録日 2008-03-14 公開日 2008-04-08 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 The solution structures of two soybean calmodulin isoforms provide a structural basis for their selective target activation properties J.Biol.Chem., 283, 2008
2RO9	Solution structure of calcium bound soybean calmodulin isoform 1 C-terminal domain 分子名称: CALCIUM ION, Calmodulin-2 著者 Ishida, H, Huang, H, Yamniuk, A.P, Takaya, Y, Vogel, H.J. 登録日 2008-03-14 公開日 2008-04-08 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 The solution structures of two soybean calmodulin isoforms provide a structural basis for their selective target activation properties J.Biol.Chem., 283, 2008

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