PDB: 223790 件ウェブページステータス検索Chemie searchBIRD

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3SDK	Structure of yeast 20S open-gate proteasome with Compound 34 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, N-[(2S)-3-(3-tert-butyl-1,2,4-oxadiazol-5-yl)-1-({(2S)-1-[(4-methylbenzyl)amino]-1-oxo-4-phenylbutan-2-yl}amino)-1-oxopropan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide, ... 著者 Sintchak, M.D. 登録日 2011-06-09 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome. Bioorg.Med.Chem.Lett., 20, 2010
3CKS	Urate oxidase complexed with 8-azaxanthine under 4.0 MPa oxygen pressure 分子名称: 8-AZAXANTHINE, OXYGEN MOLECULE, SODIUM ION, ... 著者 Colloc'h, N, Gabison, L, Chiadmi, M, Abraini, J.H, Prange, T. 登録日 2008-03-17 公開日 2008-10-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Oxygen pressurized X-ray crystallography: probing the dioxygen binding site in cofactorless urate oxidase and implications for its catalytic mechanism. Biophys.J., 95, 2008
3SHY	Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors 分子名称: 6-ethyl-5-fluoro-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ... 著者 Chen, T.T, Chen, T, Xu, Y.C. 登録日 2011-06-17 公開日 2011-08-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.647 Å) 主引用文献 Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. J.Med.Chem., 54, 2011
3SIX	Crystal structure of NodZ alpha-1,6-fucosyltransferase soaked with GDP-fucose 分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Nodulation fucosyltransferase NodZ, ... 著者 Brzezinski, K, Dauter, Z, Jaskolski, M. 登録日 2011-06-20 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structures of NodZ alpha-1,6-fucosyltransferase in complex with GDP and GDP-fucose Acta Crystallogr.,Sect.D, 68, 2012
3CP9	Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor 分子名称: 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one, Vascular endothelial growth factor receptor 2 著者 Whittington, D.A, Long, A.M, Rose, P, Gu, Y, Zhao, H. 登録日 2008-03-31 公開日 2008-06-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit. J.Med.Chem., 51, 2008
3SJS	Crystal structure of URE3-binding protein from Entamoeba histolytica, (D127A,N129A) mutant, native form 分子名称: CALCIUM ION, URE3-BP sequence specific DNA binding protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-06-21 公開日 2011-07-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of URE3-binding protein from Entamoeba histolytica to be published
3CQI	Crystal Structure of L-xylulose-5-phosphate 3-epimerase UlaE (form B) complex with sulfate 分子名称: L-ribulose-5-phosphate 3-epimerase ulaE, SULFATE ION 著者 Shi, R, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) 登録日 2008-04-03 公開日 2008-11-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of L-xylulose-5-Phosphate 3-epimerase (UlaE) from the anaerobic L-ascorbate utilization pathway of Escherichia coli: identification of a novel phosphate binding motif within a TIM barrel fold. J.Bacteriol., 190, 2008
3CQU	Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor 分子名称: Glycogen synthase kinase-3 beta, N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, RAC-alpha serine/threonine-protein kinase 著者 Pandit, J. 登録日 2008-04-03 公開日 2008-05-27 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Synthesis and structure based optimization of novel Akt inhibitors Bioorg.Med.Chem.Lett., 18, 2008
3CPR	The crystal structure of Corynebacterium glutamicum dihydrodipicolinate synthase to 2.2 A resolution 分子名称: Dihydrodipicolinate synthetase 著者 Rydel, T.J, Sturman, E.J, Rice, E.A. 登録日 2008-04-01 公開日 2008-11-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Characterization and crystal structure of lysine insensitive Corynebacterium glutamicum dihydrodipicolinate synthase (cDHDPS) protein. Arch.Biochem.Biophys., 480, 2008
3CSD	Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH and the Inhibitor Emodin 分子名称: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative ketoacyl reductase 著者 Javidpour, P. 登録日 2008-04-09 公開日 2009-04-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH and the Inhibitor Emodin To be Published
3SMC	Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound L-sulforaphane 分子名称: CHLORIDE ION, Macrophage migration inhibitory factor, N-{4-[(R)-methylsulfinyl]butyl}thioformamide, ... 著者 Crichlow, G.V, Lolis, E.J. 登録日 2011-06-27 公開日 2012-10-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates. Biochemistry, 51, 2012
3S6B	Crystal structure of methionine aminopeptidase 1b from Plasmodium Falciparum, PF10_0150 分子名称: FE (III) ION, GLYCEROL, Methionine aminopeptidase 著者 Wernimont, A.K, Artz, J.D, Crombet, L, Lew, J, Weadge, J, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Hui, R, Hills, T, Structural Genomics Consortium (SGC) 登録日 2011-05-25 公開日 2011-06-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of methionine aminopeptidase 1b from Plasmodium Falciparum, PF10_0150 To be Published
3CV0	Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphoglucoisomerase (PGI) PTS1 peptide 分子名称: 1,2-ETHANEDIOL, Peroxisome targeting signal 1 receptor PEX5, T. brucei PGI PTS1 peptide Ac-FNELSHL 著者 Sampathkumar, P, Roach, C, Michels, P.A.M, Hol, W.G.J. 登録日 2008-04-17 公開日 2008-06-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5. J.Mol.Biol., 381, 2008
3DK3	Crystal structure of mutant ABL kinase domain in complex with small molecule fragment 分子名称: 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide, Proto-oncogene tyrosine-protein kinase ABL1, SULFATE ION 著者 Lewis, H.A. 登録日 2008-06-24 公開日 2008-07-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Crystal structure of mutant ABL kinase domain in complex with small molecule fragment To be Published
3DKG	Structure of Mutant(Y1248L) MET receptor tyrosine kinase in complex with inhibitor SGX-523 分子名称: 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline, CHLORIDE ION, Hepatocyte growth factor receptor 著者 Hendle, J. 登録日 2008-06-24 公開日 2009-07-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer Ther., 8, 2009
3SA8	Crystal structure of wild-type HIV-1 protease in complex with KB83 分子名称: 3-hydroxy-N-[(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]benzamide, ACETATE ION, PHOSPHATE ION, ... 著者 Schiffer, C.A, Nalam, M.N.L. 登録日 2011-06-02 公開日 2012-06-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published
3SAG	Crystal structure of the human RRP6 catalytic domain with D313N mutation in the active site 分子名称: Exosome component 10, MAGNESIUM ION, YTTRIUM (III) ION 著者 Januszyk, K, Liu, Q, Lima, C.D. 登録日 2011-06-02 公開日 2011-07-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Activities of human RRP6 and structure of the human RRP6 catalytic domain. Rna, 17, 2011
3DGR	Crystal structure of human NAMPT complexed with ADP analogue 分子名称: Nicotinamide phosphoribosyltransferase, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER 著者 Ho, M, Burgos, E.S, Almo, S.C, Schramm, V.L. 登録日 2008-06-15 公開日 2009-08-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA, 106, 2009
3DL7	Aged Form of Mouse Acetylcholinesterase Inhibited by Tabun- Update 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, CHLORIDE ION, ... 著者 Carletti, E, Li, H, Li, B, Ekstrom, F, Nicolet, Y, Loiodice, M, Gillon, E, Froment, M.T, Lockridge, O, Schopfer, L.M, Masson, P, Nachon, F. 登録日 2008-06-26 公開日 2008-12-02 最終更新日 2021-03-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation. J.Am.Chem.Soc., 130, 2008
3DHF	Crystal structure of phosphorylated mimic form of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate 分子名称: BERYLLIUM TRIFLUORIDE ION, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, MAGNESIUM ION, ... 著者 Ho, M, Burgos, E.S, Almo, S.C, Schramm, V.L. 登録日 2008-06-17 公開日 2009-08-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA, 106, 2009
3DHS	Mapping metal-binding sites in the catalytic domain of bacterial RNase P RNA 分子名称: OSMIUM ION, RNase P RNA 著者 Pace, N.R, Kazantsev, A.V, Krivenko, A.A. 登録日 2008-06-18 公開日 2009-01-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Mapping metal-binding sites in the catalytic domain of bacterial RNase P RNA Rna, 15, 2009
3SAH	Crystal structure of the human RRP6 catalytic domain with Y436A mutation in the catalytic site 分子名称: Exosome component 10, MAGNESIUM ION, YTTRIUM (III) ION 著者 Januszyk, K, Liu, Q, Lima, C.D. 登録日 2011-06-02 公開日 2011-07-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Activities of human RRP6 and structure of the human RRP6 catalytic domain. Rna, 17, 2011
3SC0	Crystal Structure of MMACHC (1-238), a human B12 processing enzyme, complexed with MethylCobalamin 分子名称: CO-METHYLCOBALAMIN, Methylmalonic aciduria and homocystinuria type C protein 著者 Koutmos, M, Gherasim, C, Smith, J.L, Banerjee, R. 登録日 2011-06-06 公開日 2011-06-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis of multifunctionality in a vitamin B12-processing enzyme. J.Biol.Chem., 286, 2011
3DIB	Crystal structure of bovine pancreatic ribonuclease A variant (I106A) 分子名称: CHLORIDE ION, Ribonuclease pancreatic, SULFATE ION 著者 Kurpiewska, K, Font, J, Ribo, M, Vilanova, M, Lewinski, K. 登録日 2008-06-20 公開日 2008-07-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 X-ray crystallographic studies of RNase A variants engineered at the most destabilizing positions of the main hydrophobic core: further insight into protein stability Proteins, 77, 2009
3WI3	Crystal Structure of the Sld3/Treslin domain from yeast Sld3 分子名称: 1,2-ETHANEDIOL, DNA replication regulator SLD3, SULFATE ION 著者 Itou, H, Araki, H, Shirakihara, Y. 登録日 2013-09-05 公開日 2014-08-20 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of the homology domain of the eukaryotic DNA replication proteins sld3/treslin. Structure, 22, 2014

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