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3DK3

Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

Summary for 3DK3
Entry DOI10.2210/pdb3dk3/pdb
Related3DK6 3DK7
DescriptorProto-oncogene tyrosine-protein kinase ABL1, 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide, SULFATE ION, ... (4 entities in total)
Functional Keywordsdrug discovery, abl kinase, fragment based, alternative splicing, atp-binding, cell adhesion, chromosomal rearrangement, cytoplasm, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm, cytoskeleton: P00520
Total number of polymer chains2
Total formula weight68718.47
Authors
Lewis, H.A. (deposition date: 2008-06-24, release date: 2008-07-29, Last modification date: 2024-02-21)
Primary citationBounaud, P.-Y.,Gosberg, A.,Hendle, J.,Lewis, H.A.,Romero, R.,Wilson, M.E.,Zhang, F.
Crystal structure of mutant ABL kinase domain in complex with small molecule fragment
To be Published,
Experimental method
X-RAY DIFFRACTION (2.02 Å)
Structure validation

217705

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