4UMU
 
 | | Structure of MELK in complex with inhibitors | | 分子名称: | (2-ethoxy-4-{[3-(isoquinolin-7-yl)prop-2-yn-1-yl]oxy}phenyl)methanaminium, MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | | 著者 | Johnson, C.N, Berdini, V, Beke, L, Bonnet, P, Brehmer, D, Coyle, J.E, Day, P.J, Frederickson, M, Freyne, E.J.E, Gilissen, R.A.H.J, Hamlett, C.C.F, Howard, S, Meerpoel, L, McMenamin, R, Patel, S, Rees, D.C, Sharff, A, Sommen, F, Wu, T, Linders, J.T.M. | | 登録日 | 2014-05-21 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.
Acs Med.Chem.Lett., 6, 2015
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1EF7
 | | CRYSTAL STRUCTURE OF HUMAN CATHEPSIN X | | 分子名称: | CATHEPSIN X | | 著者 | Guncar, G, Klemencic, I, Turk, B, Turk, V, Karaoglanovic-Carmona, A, Juliano, L, Turk, D. | | 登録日 | 2000-02-07 | | 公開日 | 2000-03-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease.
Structure Fold.Des., 8, 2000
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4UTQ
 | | A structural model of the active ribosome-bound membrane protein insertase YidC | | 分子名称: | ATP SYNTHASE SUBUNIT C, MEMBRANE PROTEIN INSERTASE YIDC | | 著者 | Wickles, S, Singharoy, A, Andreani, J, Seemayer, S, Bischoff, L, Berninghausen, O, Soeding, J, Schulten, K, vanderSluis, E.O, Beckmann, R. | | 登録日 | 2014-07-22 | | 公開日 | 2014-07-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (8 Å) | | 主引用文献 | A Structural Model of the Active Ribosome-Bound Membrane Protein Insertase Yidc.
Elife, 3, 2014
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6L3Y
 | | Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Clado-C | | 分子名称: | (3R)-3-[[(3S)-3-ethylpiperidin-1-yl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, Lysine--tRNA ligase, ... | | 著者 | Babbar, P, Sharma, A, Mishra, S, Manickam, Y, Harlos, K. | | 登録日 | 2019-10-15 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin inhibitor, Cla-B
Chembiochem, 2021
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6LAY
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4USN
 | | The structure of the immature HIV-1 capsid in intact virus particles at sub-nm resolution | | 分子名称: | P24 | | 著者 | Schur, F.K.M, Hagen, W.J.H, Rumlova, M, Ruml, T, Mueller, B, Kraeusslich, H.-G, Briggs, J.A.G. | | 登録日 | 2014-07-11 | | 公開日 | 2014-11-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (8.8 Å) | | 主引用文献 | Structure of the Immature HIV-1 Capsid in Intact Virus Particles at 8.8 A Resolution.
Nature, 517, 2015
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1E5G
 | | Solution structure of central CP module pair of a pox virus complement inhibitor | | 分子名称: | COMPLEMENT CONTROL PROTEIN C3 | | 著者 | Henderson, C.E, Bromek, K, Mullin, N.P, Smith, B.O, Uhrin, D, Barlow, P.N. | | 登録日 | 2000-07-25 | | 公開日 | 2000-08-31 | | 最終更新日 | 2013-07-03 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure and Dynamics of the Central Ccp Module Pair of a Poxvirus Complement Control Protein
J.Mol.Biol., 307, 2001
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6KWE
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4GD4
 | | Crystal Structure of JMJD2A Complexed with Inhibitor | | 分子名称: | 2-(1H-pyrazol-3-yl)pyridine-4-carboxylic acid, CHLORIDE ION, Lysine-specific demethylase 4A, ... | | 著者 | King, O.N.F, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, McDonough, M.A, Schofield, C.J, Structural Genomics Consortium (SGC) | | 登録日 | 2012-07-31 | | 公開日 | 2012-08-15 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Crystal Structure of JMJD2A Complexed with Inhibitor
TO BE PUBLISHED
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1ENX
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1E9V
 | | XENON BOUND IN HYDROPHOBIC CHANNEL OF HYBRID CLUSTER PROTEIN FROM DESULFOVIBRIO VULGARIS | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETIC ACID, ... | | 著者 | Cooper, S.J, Bailey, S, Rizkallah, P.J, Lindley, P.F. | | 登録日 | 2000-10-27 | | 公開日 | 2001-10-25 | | 最終更新日 | 2020-12-23 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Ferricyanide Soaked Hybrid Cluster Protein at 1.2A and Xenon Mapping of the Hydrophobic Cavity at 1.8A
To be Published
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4UXT
 | | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN HEAVY CHAIN ISOFORM 5A, ... | | 著者 | Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C. | | 登録日 | 2014-08-27 | | 公開日 | 2014-09-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | | 主引用文献 | Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
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3VH8
 | | KIR3DL1 in complex with HLA-B*5701 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | | 著者 | Vivian, J.P, Rossjohn, J. | | 登録日 | 2011-08-24 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B
Nature, 479, 2011
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4PES
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1EPB
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1EPR
 | | ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-135,040 | | 分子名称: | ENDOTHIAPEPSIN, N~2~-[(2R)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-{(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-[(2-morpholin-4-ylethyl)amino]-4-oxobutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide | | 著者 | Badasso, M, Crawford, M, Cooper, J.B, Blundell, T.L. | | 登録日 | 1994-07-27 | | 公開日 | 1994-12-20 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica.
Protein Sci., 3, 1994
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1EDP
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6LOP
 | | Crystal Structure of Class IB terpene synthase bound with geranylgeraniol | | 分子名称: | (2~{E},6~{E},10~{E})-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-ol, Tetraprenyl-beta-curcumene synthase | | 著者 | Fujihashi, M, Inagi, H, Miki, K. | | 登録日 | 2020-01-07 | | 公開日 | 2020-11-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Characterization of Class IB Terpene Synthase: The First Crystal Structure Bound with a Substrate Surrogate.
Acs Chem.Biol., 15, 2020
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1EDU
 | | CRYSTAL STRUCTURE OF THE ENTH DOMAIN OF RAT EPSIN 1 | | 分子名称: | 1,2-ETHANEDIOL, EH domain binding protein EPSIN | | 著者 | Hyman, J.H, Chen, H, Decamilli, P, Brunger, A.T. | | 登録日 | 2000-01-28 | | 公開日 | 2000-05-10 | | 最終更新日 | 2018-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF).
J.Cell Biol., 149, 2000
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1EQD
 | | CRYSTAL STRUCTURE OF NITROPHORIN 4 COMPLEXED WITH CN | | 分子名称: | 5,8-DIMETHYL-1,2,3,4-TETRAVINYLPORPHINE-6,7-DIPROPIONIC ACID FERROUS COMPLEX, CITRIC ACID, CYANIDE ION, ... | | 著者 | Weichsel, A, Andersen, J.F, Roberts, S.A, Montfort, W.R. | | 登録日 | 2000-04-03 | | 公開日 | 2000-05-03 | | 最終更新日 | 2018-04-18 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Nitric oxide binding to nitrophorin 4 induces complete distal pocket burial.
Nat.Struct.Biol., 7, 2000
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1EE6
 | | CRYSTAL STRUCTURE OF PECTATE LYASE FROM BACILLUS SP. STRAIN KSM-P15. | | 分子名称: | CALCIUM ION, PECTATE LYASE | | 著者 | Akita, M, Suzuki, A, Kobayashi, T, Ito, S, Yamane, T. | | 登録日 | 2000-01-31 | | 公開日 | 2001-01-31 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The first structure of pectate lyase belonging to polysaccharide lyase family 3.
Acta Crystallogr.,Sect.D, 57, 2001
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1EQN
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6LQ7
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1ERM
 | | X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-1-ACETAMIDO-2-(3-CARBOXYPHENYL)ETHANE BORONIC ACID | | 分子名称: | 1(R)-1-ACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID, TEM-1 BETA-LACTAMASE | | 著者 | Ness, S, Martin, R, Kindler, A.M, Paetzel, M, Gold, M, Jones, J.B, Strynadka, N.C.J. | | 登録日 | 2000-04-06 | | 公開日 | 2000-05-10 | | 最終更新日 | 2012-06-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).
Biochemistry, 39, 2000
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6LK2
 | | Crystal structure of Providencia alcalifaciens 3-dehydroquinate synthase (DHQS) in complex with Mg2+, NAD and chlorogenic acid | | 分子名称: | (1R,3R,4S,5R)-3-[3-[3,4-bis(oxidanyl)phenyl]propanoyloxy]-1,4,5-tris(oxidanyl)cyclohexane-1-carboxylic acid, 1,2-ETHANEDIOL, 3-dehydroquinate synthase, ... | | 著者 | Neetu, N, Katiki, M, Kumar, P. | | 登録日 | 2019-12-17 | | 公開日 | 2020-07-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | | 主引用文献 | Structural and Biochemical Analyses Reveal that Chlorogenic Acid Inhibits the Shikimate Pathway.
J.Bacteriol., 202, 2020
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