PDB: 1980 件ウェブページステータス検索Chemie searchBIRD

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4O4R	Murine Norovirus RdRp in complex with PPNDS 分子名称: 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, RNA-dependent-RNA-polymerase, SULFATE ION 著者 Croci, R, Tarantino, D, Milani, M, Pezzullo, M, Bolognesi, M, Mastrangelo, E. 登録日 2013-12-19 公開日 2014-11-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. Febs Lett., 588, 2014
6KWR	Crystal structure of enterovirus 71 polymerase elongation complex (ddCTP form) 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (31-MER), ... 著者 Shi, W, Gong, P. 登録日 2019-09-08 公開日 2019-12-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res., 48, 2020
6KWQ	Crystal structure of enterovirus 71 polymerase elongation complex (native form) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ... 著者 Shi, W, Gong, P. 登録日 2019-09-08 公開日 2019-12-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res., 48, 2020
2F8E	Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with uridylylated VPg protein 分子名称: MAGNESIUM ION, MANGANESE (II) ION, RNA-dependent RNA polymerase, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2005-12-02 公開日 2006-03-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
1WAC	Back-priming mode of Phi6 RNA-dependent RNA polymerase 分子名称: P2 PROTEIN 著者 Laurila, M.R.L, Salgado, P.S, Stuart, D.I, Grimes, J.M, Bamford, D.H. 登録日 2004-10-26 公開日 2005-01-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Back-Priming Mode of Phi6 RNA-Dependent RNA Polymerase J.Gen.Virol., 86, 2005
4HHJ	Dengue serotype 3 RNA-dependent RNA polymerase 分子名称: DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Non-structural protein 5, ... 著者 Noble, C.G, Lescar, J. 登録日 2012-10-10 公開日 2013-02-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor J.Virol., 87, 2013
3VWS	Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107 分子名称: 5-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-1-benzofuran-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, Non-structural protein 5, ... 著者 Noble, C.G, Lescar, J. 登録日 2012-08-31 公開日 2013-02-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor J.Virol., 87, 2013
3N6L	The crystal structure of RNA-dependent RNA polymerase of EV71 virus 分子名称: NICKEL (II) ION, RNA-dependent RNA polymerase 著者 Wu, Y, Rao, Z.H. 登録日 2010-05-26 公開日 2011-06-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell, 1, 2010
3QID	Crystal structures and functional analysis of murine norovirus RNA-dependent RNA polymerase 分子名称: GLYCEROL, MANGANESE (III) ION, RNA dependent RNA polymerase, ... 著者 Kim, K.H, Intekhab, A, Lee, J.H. 登録日 2011-01-27 公開日 2011-12-21 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase. J.Gen.Virol., 92, 2011
8IIC	Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta40 mutant (residues 41-546) 分子名称: Polymerase polyprotein 著者 Fang, X, Lu, G, Hou, C, Gong, P. 登録日 2023-02-24 公開日 2023-06-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023
8IIB	Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta85 mutant (residues 86-546) 分子名称: CADMIUM ION, CHLORIDE ION, MAGNESIUM ION, ... 著者 Fang, X, Lu, G, Hou, C, Gong, P. 登録日 2023-02-24 公開日 2023-06-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023
8WIL	Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D55 construct) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ... 著者 Wang, X, Jing, X, Deng, F, Gong, P. 登録日 2023-09-24 公開日 2024-01-17 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase. Nucleic Acids Res., 52, 2024
8WIM	Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D307 construct) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ... 著者 Wang, X, Jing, X, Deng, F, Gong, P. 登録日 2023-09-24 公開日 2024-01-17 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase. Nucleic Acids Res., 52, 2024
1U09	Footand Mouth Disease Virus RNA-dependent RNA polymerase 分子名称: polyprotein 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2004-07-13 公開日 2004-08-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA J.Biol.Chem., 279, 2004
3JA4	RNA-dependent RNA polymerases of transcribing cypoviruses 分子名称: RNA-dependent RNA polymerase 著者 Liu, H, Cheng, L. 登録日 2015-04-20 公開日 2015-10-28 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus. Science, 349, 2015
4HDH	Crystal Structure of viral RdRp in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION 著者 Surana, P, Nair, D.T. 登録日 2012-10-02 公開日 2013-12-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
4HDG	Crystal Structure of viral RdRp in complex with GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION 著者 Surana, P, Nair, D.T. 登録日 2012-10-02 公開日 2013-12-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
4MTP	RdRp from Japanesese Encephalitis Virus 分子名称: RNA dependent RNA polymerase, ZINC ION 著者 Surana, P, Nair, D.T. 登録日 2013-09-20 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
2PGG	Crystal Structure of a Birnavirus (IBDV) RNA-dependent RNA Polymerase VP1 分子名称: RNA-directed RNA polymerase 著者 Pan, J, Vakharia, V.N, Tao, Y.J. 登録日 2007-04-09 公開日 2007-05-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The structure of a birnavirus polymerase reveals a distinct active site topology. Proc.Natl.Acad.Sci.Usa, 104, 2007
1YUY	HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE GENOTYPE 2a 分子名称: RNA-Dependent RNA polymerase, SULFATE ION 著者 Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. 登録日 2005-02-14 公開日 2005-03-22 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J.Biol.Chem., 280, 2005
6TZ0	In situ structure of BmCPV RNA-dependent RNA polymerase at abortive state 分子名称: RNA-dependent RNA Polymerase, Viral structural protein 4 著者 Cui, Y.X, Zhang, Y.N, Sun, J.C, Zhou, Z.H. 登録日 2019-08-09 公開日 2019-11-20 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Conservative transcription in three steps visualized in a double-stranded RNA virus. Nat.Struct.Mol.Biol., 26, 2019
7B3C	Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2) 分子名称: DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*A)-D(P*(RMP))-R(P*GP*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... 著者 Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. 登録日 2020-11-30 公開日 2020-12-23 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
2JC0	CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH INHIBITOR SB655264 分子名称: (2S,4S,5R)-2-ISOBUTYL-5-(2-THIENYL)-1-[4-(TRIFLUOROMETHYL)BENZOYL]PYRROLIDINE-2,4-DICARBOXYLIC ACID, RNA-DEPENDENT RNA-POLYMERASE 著者 Wonacott, A, Skarzynski, T, Singh, O.M. 登録日 2006-12-18 公開日 2007-02-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate. J.Med.Chem., 50, 2007
2JC1	CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH INHIBITOR SB698223 分子名称: (2S,4S,5R)-1-(4-TERT-BUTYLBENZOYL)-2-ISOBUTYL-5-(1,3-THIAZOL-2-YL)PYRROLIDINE-2,4-DICARBOXYLIC ACID, RNA-DEPENDENT RNA-POLYMERASE 著者 Wonacott, A, Skarzynski, T, Singh, O.M. 登録日 2006-12-18 公開日 2007-02-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate. J.Med.Chem., 50, 2007
4Y3C	I304V 3D polymerase mutant of EMCV 分子名称: 3D polymerase, CHLORIDE ION, GLYCEROL 著者 Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L. 登録日 2015-02-10 公開日 2015-04-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015

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