1YOM
| Crystal structure of Src kinase domain in complex with Purvalanol A | 分子名称: | 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL, Proto-oncogene tyrosine-protein kinase Src | 著者 | Breitenlechner, C.B, Kairies, N.A, Honold, K, Scheiblich, S, Koll, H, Greiter, E, Koch, S, Schaefer, W, Huber, R, Engh, R.A. | 登録日 | 2005-01-27 | 公開日 | 2006-01-27 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of active SRC kinase domain complexes J.Mol.Biol., 353, 2005
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1XBB
| Crystal structure of the syk tyrosine kinase domain with Gleevec | 分子名称: | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Tyrosine-protein kinase SYK | 著者 | Nienaber, V.L, Atwell, S, Adams, J.M, Badger, J, Buchanan, M.D, Feil, I.K, Froning, K.J, Gao, X, Hendle, J, Keegan, K, Leon, B.C, Muller-Deickmann, H.J, Noland, B.W, Post, K, Rajashankar, K.R, Ramos, A, Russell, M, Burley, S.K, Buchanan, S.G. | 登録日 | 2004-08-30 | 公開日 | 2004-11-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase J.Biol.Chem., 279, 2004
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1XBC
| Crystal structure of the syk tyrosine kinase domain with Staurosporin | 分子名称: | STAUROSPORINE, Tyrosine-protein kinase SYK | 著者 | Badger, J, Atwell, S, Adams, J.M, Buchanan, M.D, Feil, I.K, Froning, K.J, Gao, X, Hendle, J, Keegan, K, Leon, B.C, Muller-Deickmann, H.J, Nienaber, V.L, Noland, B.W, Post, K, Rajashankar, K.R, Ramos, A, Russell, M, Burley, S.K, Buchanan, S.G. | 登録日 | 2004-08-30 | 公開日 | 2004-11-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase J.Biol.Chem., 279, 2004
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1YI6
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1Y6A
| Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor | 分子名称: | N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE, Vascular endothelial growth factor receptor 2 | 著者 | Harris, P.A, Cheung, M, Hunter, R.N, Brown, M.L, Veal, J.M, Nolte, R.T, Wang, L, Liu, W, Crosby, R.M, Johnson, J.H, Epperly, A.H, Kumar, R, Luttrell, D.K, Stafford, J.A. | 登録日 | 2004-12-05 | 公開日 | 2005-06-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J.Med.Chem., 48, 2005
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1Y6B
| Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor | 分子名称: | N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE, Vascular endothelial growth factor receptor 2 | 著者 | Harris, P.A, Cheung, M, Hunter, R.N, Brown, M.L, Veal, J.M, Nolte, R.T, Wang, L, Liu, W, Crosby, R.M, Johnson, J.H, Epperly, A.H, Kumar, R, Luttrell, D.K, Stafford, J.A. | 登録日 | 2004-12-05 | 公開日 | 2005-06-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J.Med.Chem., 48, 2005
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1XKK
| EGFR kinase domain complexed with a quinazoline inhibitor- GW572016 | 分子名称: | Epidermal growth factor receptor, N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE, PHOSPHATE ION | 著者 | Wood, E.R, Truesdale, A.T, McDonald, O.B, Yuan, D, Hassell, A, Dickerson, S.H, Ellis, B, Pennisi, C, Horne, E, Lackey, K, Alligood, K.J, Rusnak, D.W, Gilmer, T.M, Shewchuk, L.M. | 登録日 | 2004-09-29 | 公開日 | 2004-12-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res., 64, 2004
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8YGX
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8W3W
| Crystal structure of IRAK4 in complex with compound 4 | 分子名称: | 7-methoxy-1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}isoquinoline-6-carboxamide, Interleukin-1 receptor-associated kinase 4 | 著者 | Han, S, Knafels, J.D. | 登録日 | 2024-02-22 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.976 Å) | 主引用文献 | In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833). Acs Med.Chem.Lett., 15, 2024
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8YGZ
| The Crystal Structure of TGF beta R2 kinase domain from Biortus. | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, TGF-beta receptor type-2 | 著者 | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | 登録日 | 2024-02-27 | 公開日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The Crystal Structure of TGF beta R2 kinase domain from Biortus. To Be Published
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1SNX
| CRYSTAL STRUCTURE OF APO INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN | 分子名称: | Tyrosine-protein kinase ITK/TSK | 著者 | Brown, K, Long, J.M, Vial, S.C, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T. | 登録日 | 2004-03-12 | 公開日 | 2004-07-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J.Biol.Chem., 279, 2004
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8XLO
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8XLQ
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8XPV
| The Crystal Structure of EphA2 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea, Ephrin type-A receptor 2, ... | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y. | 登録日 | 2024-01-04 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | The Crystal Structure of EphA2 from Biortus. To Be Published
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8W3X
| Crystal structure of IRAK4 in complex with compound 6 | 分子名称: | 7-ethoxy-1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}isoquinoline-6-carboxamide, Interleukin-1 receptor-associated kinase 4 | 著者 | Han, S, Knafels, J.D. | 登録日 | 2024-02-22 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.765 Å) | 主引用文献 | In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833). Acs Med.Chem.Lett., 15, 2024
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8XOX
| The Crystal Structure of FAK2 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide, Protein-tyrosine kinase 2-beta | 著者 | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | 登録日 | 2024-01-02 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Crystal Structure of FAK2 from Biortus. To Be Published
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8W1L
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1P14
| Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase | 分子名称: | insulin receptor | 著者 | Li, S, Covino, N.D, Stein, E.G, Till, J.H, Hubbard, S.R. | 登録日 | 2003-04-11 | 公開日 | 2003-07-22 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor J.Biol.Chem., 278, 2003
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1U4D
| Structure of the ACK1 Kinase Domain bound to Debromohymenialdisine | 分子名称: | Activated CDC42 kinase 1, CHLORIDE ION, DEBROMOHYMENIALDISINE | 著者 | Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. | 登録日 | 2004-07-23 | 公開日 | 2004-08-31 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004
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1U46
| Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1 | 分子名称: | Activated CDC42 kinase 1, CHLORIDE ION | 著者 | Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. | 登録日 | 2004-07-23 | 公開日 | 2004-08-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004
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1U59
| Crystal Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine | 分子名称: | STAUROSPORINE, Tyrosine-protein kinase ZAP-70 | 著者 | Jin, L, Pluskey, S, Petrella, E.C, Cantin, S.M, Gorga, J.C, Rynkiewicz, M.J, Pandey, P, Strickler, J.E, Babine, R.E, Weaver, D.T, Seidl, K.J. | 登録日 | 2004-07-27 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine: IMPLICATIONS FOR THE DESIGN OF SELECTIVE INHIBITORS J.Biol.Chem., 279, 2004
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1PKG
| Structure of a c-Kit Kinase Product Complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, c-kit protein | 著者 | Mol, C.D, Lim, K.B, Sridhar, V, Zou, H, Chien, E.Y.T, Sang, B.-C, Nowakowski, J, Kassel, D.B, Cronin, C.N, McRee, D.E. | 登録日 | 2003-06-05 | 公開日 | 2003-08-12 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation. J.Biol.Chem., 278, 2003
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1U54
| Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the CDC42-associated Tyrosine Kinase ACK1 bound to AMP-PCP | 分子名称: | Activated CDC42 kinase 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | 著者 | Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. | 登録日 | 2004-07-26 | 公開日 | 2004-08-31 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004
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1OPJ
| Structural basis for the auto-inhibition of c-Abl tyrosine kinase | 分子名称: | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, MYRISTIC ACID, ... | 著者 | Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. | 登録日 | 2003-03-06 | 公開日 | 2003-04-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003
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1RJB
| Crystal Structure of FLT3 | 分子名称: | FL cytokine receptor | 著者 | Griffith, J, Black, J, Faerman, C, Swenson, L, Wynn, M, Lu, F, Lippke, J, Saxena, K. | 登録日 | 2003-11-19 | 公開日 | 2004-02-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Mol.Cell, 13, 2004
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