PDB: 117 件ウェブページステータス検索Chemie searchBIRD

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4FT2	crystal structure of Zea mays ZMET2 in complex H3(1-15)K9me2 peptide and SAH 分子名称: DNA (cytosine-5)-methyltransferase 1, H3 peptide, S-ADENOSYL-L-HOMOCYSTEINE 著者 Du, J, Patel, D.J. 登録日 2012-06-27 公開日 2012-10-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012
3PT6	Crystal structure of mouse DNMT1(650-1602) in complex with DNA 分子名称: DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Song, J, Patel, D.J. 登録日 2010-12-02 公開日 2010-12-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
7SFD	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3543105A 分子名称: (2S)-2-({3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl}sulfanyl)-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... 著者 Horton, J.R, Pathuri, S, Cheng, X. 登録日 2021-10-03 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFF	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3852279B 分子名称: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-[4-(trifluoromethyl)phenyl]acetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... 著者 Horton, J.R, Pathuri, S, Cheng, X. 登録日 2021-10-03 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFC	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3735967A 分子名称: 1,2-ETHANEDIOL, DNA (12-MER), DNA (cytosine-5)-methyltransferase 1, ... 著者 Horton, J.R, Pathuri, S, Cheng, X. 登録日 2021-10-03 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFG	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Cofactor SAM 分子名称: 1,2-ETHANEDIOL, DNA (cytosine-5)-methyltransferase 1, DNA Strand 1, ... 著者 Horton, J.R, Pathuri, S, Cheng, X. 登録日 2021-10-03 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFE	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830334A 分子名称: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]amino}-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... 著者 Horton, J.R, Pathuri, S, Cheng, X. 登録日 2021-10-03 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
3PT9	Crystal structure of mouse DNMT1(731-1602) in the free state 分子名称: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Song, J, Patel, D.J. 登録日 2010-12-02 公開日 2010-12-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
7T02	Cryo-EM structure of DNMT5 pseudo-ternary complex solved by incubation with hemimethylated DNA and SAM 分子名称: DNA (5'-D(*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), DNA repair protein Rad8, ... 著者 Wang, J, Patel, D.J. 登録日 2021-11-29 公開日 2022-02-23 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
3PTA	Crystal structure of human DNMT1(646-1600) in complex with DNA 分子名称: DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Song, J, Patel, D.J. 登録日 2010-12-02 公開日 2010-12-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
3SWR	Structure of human DNMT1 (601-1600) in complex with Sinefungin 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (cytosine-5)-methyltransferase 1, ... 著者 Hashimoto, H, Cheng, X. 登録日 2011-07-14 公開日 2011-08-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Structure of human DNMT1 (residues 600-1600) in complex with Sinefungin To be Published
3AV4	Crystal structure of mouse DNA methyltransferase 1 分子名称: DNA (cytosine-5)-methyltransferase 1, ZINC ION 著者 Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. 登録日 2011-02-22 公開日 2011-05-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
3AV6	Crystal structure of mouse DNA methyltransferase 1 with AdoMet 分子名称: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYLMETHIONINE, ZINC ION 著者 Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. 登録日 2011-02-22 公開日 2011-05-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
3AV5	Crystal structure of mouse DNA methyltransferase 1 with AdoHcy 分子名称: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. 登録日 2011-02-22 公開日 2011-05-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
6W8W	Crystal structure of mouse DNMT1 in complex with CCG DNA 分子名称: CCG DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), CCG DNA (5'-D(*CP*CP*TP*TP*CP*(C49)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Anteneh, H, Song, J. 登録日 2020-03-21 公開日 2020-07-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context Nat Commun, 2020
6W8V	Crystal structure of mouse DNMT1 in complex with ACG DNA 分子名称: ACG DNA (5'-D(*AP*CP*TP*TP*AP*(C49)P*GP*GP*AP*AP*GP*G)-3'), ACG DNA (5'-D(*CP*CP*TP*TP*CP*(5CM)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Anteneh, H, Song, J. 登録日 2020-03-21 公開日 2020-07-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context Nat Commun, 2020
6PA7	The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome. 分子名称: CHLORIDE ION, DNA (167-MER), DNA (cytosine-5)-methyltransferase 3A, ... 著者 Xu, T.H, Liu, M, Zhou, X.E, Liang, G, Zhao, G, Xu, H.E, Melcher, K, Jones, P.A. 登録日 2019-06-11 公開日 2020-06-17 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature, 586, 2020

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