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8J9Z
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cryo-EM structure of viral topoisomerase in conformation 2
分子名称: DNA topoisomerase 2
著者Deng, Z.
登録日2023-05-05
公開日2023-08-16
最終更新日2023-11-29
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Cryo-EM structures of African swine fever virus topoisomerase.
Mbio, 14, 2023
1CY1
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COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'PTPTPT
分子名称: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-3',5'-DIPHOSPHATE, ...
著者Feinberg, H, Changela, A, Mondragon, A.
登録日1999-08-31
公開日2000-03-03
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Protein-nucleotide interactions in E. coli DNA topoisomerase I.
Nat.Struct.Biol., 6, 1999
1CY9
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CRYSTAL STRUCTURE OF THE 30 KDA FRAGMENT OF E. COLI DNA TOPOISOMERASE I. MONOCLINIC FORM
分子名称: DNA TOPOISOMERASE I
著者Feinberg, H, Lima, C, Mondragon, A.
登録日1999-08-31
公開日2000-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Conformational changes in E. coli DNA topoisomerase I.
Nat.Struct.Biol., 6, 1999
1CY2
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BU of 1cy2 by Molmil
COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH TPTPTP3'
分子名称: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-5'-PHOSPHATE
著者Feinberg, H, Changela, A, Mondragon, A.
登録日1999-08-31
公開日2000-03-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Protein-nucleotide interactions in E. coli DNA topoisomerase I.
Nat.Struct.Biol., 6, 1999
1CY8
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COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'-THYMIDINE MONOPHOSPHATE AND 3'-THYMIDINE MONOPHOSPHATE
分子名称: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-3'-PHOSPHATE, ...
著者Feinberg, H, Changela, A, Mondragon, A.
登録日1999-08-31
公開日2000-03-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Protein-nucleotide interactions in E. coli DNA topoisomerase I.
Nat.Struct.Biol., 6, 1999
1CYY
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CRYSTAL STRUCTURE OF THE 30 KDA FRAGMENT OF E. COLI DNA TOPOISOMERASE I. HEXAGONAL FORM
分子名称: DNA TOPOISOMERASE I, ZINC ION
著者Feinberg, H, Lima, C, Mondragon, A.
登録日1999-08-31
公開日2000-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Conformational changes in E. coli DNA topoisomerase I.
Nat.Struct.Biol., 6, 1999
1CY7
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COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'-THYMIDINE MONOPHOSPHATE
分子名称: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-5'-PHOSPHATE
著者Feinberg, H, Changela, A, Mondragon, A.
登録日1999-08-31
公開日2000-03-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Protein-nucleotide interactions in E. coli DNA topoisomerase I.
Nat.Struct.Biol., 6, 1999
1CY6
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BU of 1cy6 by Molmil
COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 3' THYMIDINE MONOPHOSPHATE
分子名称: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-3'-PHOSPHATE
著者Feinberg, H, Changela, A, Mondragon, A.
登録日1999-08-31
公開日2000-03-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Protein-nucleotide interactions in E. coli DNA topoisomerase I.
Nat.Struct.Biol., 6, 1999
1CY4
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COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'pTpTpTp3'
分子名称: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-5'-PHOSPHATE
著者Feinberg, H, Changela, A, Mondragon, A.
登録日1999-08-31
公開日2000-03-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Protein-nucleotide interactions in E. coli DNA topoisomerase I.
Nat.Struct.Biol., 6, 1999
4I3H
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A three-gate structure of topoisomerase IV from Streptococcus pneumoniae
分子名称: DNA (5'-D(*CP*AP*AP*AP*GP*GP*CP*GP*GP*TP*AP*AP*TP*AP*CP*GP*GP*TP*TP*AP*TP*CP*CP*AP*CP*AP*GP*AP*AP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*TP*TP*CP*TP*GP*TP*GP*GP*AP*TP*AP*AP*CP*CP*GP*TP*AP*TP*TP*AP*CP*CP*GP*CP*CP*TP*TP*TP*G)-3'), MAGNESIUM ION, ...
著者Laponogov, I, Veselkov, D.A, Pan, X.-S, Crevel, I, Fisher, L.M, Sanderson, M.R.
登録日2012-11-26
公開日2013-08-28
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport.
Nucleic Acids Res., 41, 2013
2ZBK
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Crystal structure of an intact type II DNA topoisomerase: insights into DNA transfer mechanisms
分子名称: RADICICOL, Type 2 DNA topoisomerase 6 subunit B, Type II DNA topoisomerase VI subunit A
著者Graille, M, Cladiere, L, Durand, D, Lecointe, F, Forterre, P, van Tilbeurgh, H, Paris-Sud Yeast Structural Genomics (YSG)
登録日2007-10-22
公開日2008-02-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.56 Å)
主引用文献Crystal Structure of an Intact Type II DNA Topoisomerase: Insights into DNA Transfer Mechanisms
Structure, 16, 2008
1OIS
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YEAST DNA TOPOISOMERASE I, N-TERMINAL FRAGMENT
分子名称: DNA TOPOISOMERASE I
著者Lue, N, Sharma, A, Mondragon, A, Wang, J.C.
登録日1996-09-14
公開日1997-03-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications.
Structure, 3, 1995
1ECL
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AMINO TERMINAL 67KDA DOMAIN OF ESCHERICHIA COLI DNA TOPOISOMERASE I (RESIDUES 2-590 OF MATURE PROTEIN) CLONING ARTIFACT ADDS TWO RESIDUES TO THE AMINO-TERMINUS WHICH WERE NOT OBSERVED IN THE EXPERIMENTAL ELECTRON DENSITY (GLY-2, SER-1).
分子名称: ESCHERICHIA COLI TOPOISOMERASE I
著者Lima, C.D, Wang, J.C, Mondragon, A.
登録日1995-05-05
公開日1995-07-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I.
Nature, 367, 1994
1CY0
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COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 3'-5'-ADENOSINE DIPHOSPHATE
分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, DNA TOPOISOMERASE I
著者Feinberg, H, Changela, A, Mondragon, A.
登録日1999-08-31
公開日2000-03-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Protein-nucleotide interactions in E. coli DNA topoisomerase I.
Nat.Struct.Biol., 6, 1999
4FM9
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Human topoisomerase II alpha bound to DNA
分子名称: DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(P*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), DNA topoisomerase 2-alpha, ...
著者Wendorff, T.J, Schmidt, B.H, Heslop, P, Austin, C.A, Berger, J.M.
登録日2012-06-15
公開日2012-08-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage.
J.Mol.Biol., 424, 2012
5GWI
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Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R
分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ...
著者Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L.
登録日2016-09-12
公開日2017-08-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.737 Å)
主引用文献Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWK
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Human topoisomerase IIalpha in complex with DNA and etoposide
分子名称: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
著者Wang, Y.R, Wu, C.C, Chan, N.L.
登録日2016-09-12
公開日2017-08-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.152 Å)
主引用文献Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWJ
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Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873S
分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ...
著者Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L.
登録日2016-09-12
公開日2017-08-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.566 Å)
主引用文献Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
4LP0
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Crystal structure of a topoisomerase ATP inhibitor
分子名称: 6'-[(ethylcarbamoyl)amino]-4'-[4-(trifluoromethyl)-1,3-thiazol-2-yl]-3,3'-bipyridine-5-carboxylic acid, Topoisomerase IV subunit B
著者Basarab, G.S, Manchester, J.I, Bist, S, Boriack-Sjodin, P.A, Dangel, B, Illingsworth, R, Uria-Nickelsen, M, Sherer, B.A, Sriram, S, Eakin, A.E.
登録日2013-07-14
公開日2013-11-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents.
J.Med.Chem., 56, 2013
5J5Q
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AMP-PNP-stabilized ATPase domain of topoisomerase IV from Streptococcus pneumoniae, complex type II
分子名称: DNA (5'-D(*GP*CP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*GP*C)-3'), DNA topoisomerase 4 subunit B, MAGNESIUM ION, ...
著者Laponogov, I, Pan, X.-S, Skamrova, G, Umrekar, T, Fisher, L.M, Sanderson, M.R.
登録日2016-04-03
公開日2017-07-26
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase.
Nat Commun, 9, 2018
5J5P
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AMP-PNP-stabilized ATPase domain of topoisomerase IV from Streptococcus pneumoniae, complex type I
分子名称: DNA (5'-D(*GP*CP*GP*CP*GP*C)-3'), DNA topoisomerase 4 subunit B, MAGNESIUM ION, ...
著者Laponogov, I, Pan, X.-S, Skamrova, G, Umrekar, T, Fisher, L.M, Sanderson, M.R.
登録日2016-04-03
公開日2017-07-26
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase.
Nat Commun, 9, 2018
4CGY
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Crystal structure of the human topoisomerase III alpha-RMI1 complex
分子名称: DNA TOPOISOMERASE 3-ALPHA, MAGNESIUM ION, RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1
著者Bocquet, N, Bunker, R.D, Thoma, N.H.
登録日2013-11-27
公開日2014-02-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structural and Mechanistic Insight Into Holliday-Junction Dissolution by Topoisomerase Iiialpha and Rmi1
Nat.Struct.Mol.Biol., 21, 2014
4LPB
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Crystal structure of a topoisomerase ATPase inhibitor
分子名称: 1-ethyl-3-{5'-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]-3,3'-bipyridin-6-yl}urea, Topoisomerase IV subunit B
著者Boriack-Sjodin, A.
登録日2013-07-15
公開日2013-10-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents.
J.Med.Chem., 56, 2013
4MN4
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Structural Basis for the MukB-topoisomerase IV Interaction
分子名称: Chromosome partition protein MukB, DNA topoisomerase 4 subunit A
著者Vos, S.M, Stewart, N.K, Oakley, M.G, Berger, J.M.
登録日2013-09-09
公開日2013-10-23
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for the MukB-topoisomerase IV interaction and its functional implications in vivo.
Embo J., 32, 2013
1A41
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TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS
分子名称: SULFATE ION, TOPOISOMERASE I
著者Cheng, C, Kussie, P, Pavletich, N, Shuman, S.
登録日1998-02-10
公開日1999-06-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases.
Cell(Cambridge,Mass.), 92, 1998

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