8R08
| Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-31 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8QZS
| Cryo-EM structure of the cross-exon B-like complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Microfibrillar-associated protein 1, NHP2-like protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-29 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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3SIU
| Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, monomeric form | 分子名称: | NHP2-like protein 1, SULFATE ION, U4/U6 small nuclear ribonucleoprotein Prp31, ... | 著者 | Liu, S, Ghalei, H, Luhrmann, R, Wahl, M.C. | 登録日 | 2011-06-20 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.626 Å) | 主引用文献 | Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. Rna, 17, 2011
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8QPE
| Cryo-EM Structure of Pre-B-like Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Microfibrillar-associated protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-01 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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5GAM
| Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, ... | 著者 | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | 登録日 | 2015-12-15 | 公開日 | 2016-02-03 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution Nature, 530, 2016
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7Q4P
| U2 snRNP after ATP-dependent remodelling | 分子名称: | PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, Splicing factor 3A subunit 3, ... | 著者 | Tholen, J, Galej, W.P. | 登録日 | 2021-11-01 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
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8QXD
| Cryo-EM structure of the cross-exon pre-B complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-24 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (9.6 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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7Q3L
| Human 17S U2 snRNP 5' domain | 分子名称: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ... | 著者 | Tholen, J, Galej, W.P. | 登録日 | 2021-10-28 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
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8QPK
| Cryo-EM Structure of Pre-B+5'ss Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-02 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8QPA
| Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-01 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8QOZ
| Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss RNA oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-09-29 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8QP8
| Cryo-EM Structure of Pre-B Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-09-30 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8QPB
| Cryo-EM Structure of Pre-B+ATP Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-01 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8QP9
| Cryo-EM Structure of Pre-B+AMPPNP Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-09-30 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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5ZWN
| Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.3 angstrom (Part II: U1 snRNP region) | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, Pre-mRNA-processing factor 39, Pre-mRNA-splicing ATP-dependent RNA helicase PRP28, ... | 著者 | Bai, R, Wan, R, Yan, C, Lei, J, Shi, Y. | 登録日 | 2018-05-16 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation Science, 360, 2018
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5GAO
| Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP | 分子名称: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Saccharomyces cerevisiae strain UOA_M2 chromosome 5 sequence, ... | 著者 | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | 登録日 | 2015-12-15 | 公開日 | 2016-01-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. Nature, 530, 2016
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6QW6
| Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Charenton, C, Wilkinson, M.E, Nagai, K. | 登録日 | 2019-03-05 | 公開日 | 2019-04-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Mechanism of 5' splice site transfer for human spliceosome activation. Science, 364, 2019
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6NQI
| Prp8 RH domain from C. merolae | 分子名称: | BETA-MERCAPTOETHANOL, Pre-mRNA splicing factor PRP8 | 著者 | Garside, E.L, MacMillan, A.M. | 登録日 | 2019-01-21 | 公開日 | 2019-05-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Prp8 in a Reduced Spliceosome Lacks a Conserved Toggle that Correlates with Splicing Complexity across Diverse Taxa. J.Mol.Biol., 431, 2019
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5M5P
| S. cerevisiae spliceosomal helicase Brr2 (271-end) in complex with the Jab/MPN domain of S. cerevisiae Prp8 | 分子名称: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | 著者 | Becke, C, Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | 登録日 | 2016-10-22 | 公開日 | 2016-12-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2. Cell Cycle, 16, 2017
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4I43
| Crystal structure of Prp8:Aar2 complex | 分子名称: | A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | 著者 | Galej, W.P, Oubridge, C, Newman, A.J, Nagai, K. | 登録日 | 2012-11-27 | 公開日 | 2013-01-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of Prp8 reveals active site cavity of the spliceosome. Nature, 493, 2013
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4BWS
| Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD. | 分子名称: | CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2, POLYGLUTAMINE-BINDING PROTEIN 1, THIOREDOXIN-LIKE PROTEIN 4A | 著者 | Mizuguchi, M, Obita, T, Serita, T, Kojima, R, Morimoto, T, Nabeshima, Y, Okazawa, H. | 登録日 | 2013-07-04 | 公開日 | 2014-04-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mutations in the Pqbp1 Gene Prevent its Interaction with the Spliceosomal Protein U5-15Kd. Nat.Commun., 5, 2014
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4BWQ
| Crystal structure of U5-15kD in a complex with PQBP1 | 分子名称: | POLYGLUTAMINE-BINDING PROTEIN 1, THIOREDOXIN-LIKE PROTEIN 4A | 著者 | Mizuguchi, M, Obita, T, Serita, T, Kojima, R, Morimoto, T, Nabeshima, Y, Okazawa, H. | 登録日 | 2013-07-04 | 公開日 | 2014-04-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Mutations in the Pqbp1 Gene Prevent its Interaction with the Spliceosomal Protein U5-15Kd. Nat.Commun., 5, 2014
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1ZWZ
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3ENB
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4RVQ
| PWI-like domain of Chaetomium thermophilum Brr2 | 分子名称: | 1,2-ETHANEDIOL, Pre-mRNA splicing helicase-like protein, SULFATE ION | 著者 | Absmeier, E, Rosenberger, L, Santos, K.F, Becke, C, Wahl, M.C. | 登録日 | 2014-11-27 | 公開日 | 2015-04-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.135 Å) | 主引用文献 | A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein. Acta Crystallogr.,Sect.D, 71, 2015
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