3CZF
| Crystal structure of HLA-B*2709 complexed with the glucagon receptor (GR) peptide (residues 412-420) | 分子名称: | BETA-2-MICROGLOBULIN, GLUCAGON RECEPTOR PEPTIDE, GLYCEROL, ... | 著者 | Loll, B, Fiorillo, M.T, Rueckert, C, Saenger, W, Sorrentino, R, Ziegler, A, Uchanska-Ziegler, B. | 登録日 | 2008-04-29 | 公開日 | 2009-04-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection. Front Immunol, 11, 2020
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7LCI
| PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex | 分子名称: | 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M. | 登録日 | 2021-01-11 | 公開日 | 2021-01-20 | 最終更新日 | 2021-09-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Evolving cryo-EM structural approaches for GPCR drug discovery. Structure, 29, 2021
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7LCJ
| PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex | 分子名称: | 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor | 著者 | Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M. | 登録日 | 2021-01-11 | 公開日 | 2021-01-20 | 最終更新日 | 2021-09-15 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Evolving cryo-EM structural approaches for GPCR drug discovery. Structure, 29, 2021
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7LCK
| PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R) | 分子名称: | 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor | 著者 | Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M. | 登録日 | 2021-01-11 | 公開日 | 2021-01-20 | 最終更新日 | 2021-09-15 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Evolving cryo-EM structural approaches for GPCR drug discovery. Structure, 29, 2021
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6VCB
| Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator | 分子名称: | 1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole, Glucagon-like peptide 1, Glucagon-like peptide 1 receptor, ... | 著者 | Sun, B, Feng, D, Bueno, A, Kobilka, B, Sloop, K. | 登録日 | 2019-12-20 | 公開日 | 2020-07-22 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into probe-dependent positive allosterism of the GLP-1 receptor. Nat.Chem.Biol., 16, 2020
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6B3J
| 3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex | 分子名称: | Exendin-P5, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liang, Y.L, Khoshouei, M, Glukhova, A, Furness, S.G.B, Koole, C, Zhao, P, Clydesdale, L, Thal, D.M, Radjainia, M, Danev, R, Baumeister, W, Wang, M.W, Miller, L.J, Christopoulos, A, Sexton, P.M, Wootten, D. | 登録日 | 2017-09-22 | 公開日 | 2018-02-21 | 最終更新日 | 2020-01-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. Nature, 555, 2018
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2M5P
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6KJV
| Structure of thermal-stabilised(M9) human GLP-1 receptor transmembrane domain | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Glucagon-like peptide 1 receptor,Endolysin,Glucagon-like peptide 1 receptor, N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine | 著者 | Song, G. | 登録日 | 2019-07-23 | 公開日 | 2019-11-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Mutagenesis facilitated crystallization of GLP-1R. Iucrj, 6, 2019
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5VEW
| Structure of the human GLP-1 receptor complex with PF-06372222 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Glucagon-like peptide 1 receptor,Endolysin chimera, N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine, ... | 著者 | Song, G, Yang, D, Wang, Y, Graaf, C.D, Zhou, Q, Jiang, S, Liu, K, Cai, X, Dai, A, Lin, G, Liu, D, Wu, F, Wu, Y, Zhao, S, Ye, L, Han, G.W, Lau, J, Wu, B, Hanson, M.A, Liu, Z.-J, Wang, M.-W, Stevens, R.C. | 登録日 | 2017-04-05 | 公開日 | 2017-05-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature, 546, 2017
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5VEX
| Structure of the human GLP-1 receptor complex with NNC0640 | 分子名称: | 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide, Glucagon-like peptide 1 receptor, Endolysin chimera | 著者 | Song, G, Yang, D, Wang, Y, Graaf, C.D, Zhou, Q, Jiang, S, Liu, K, Cai, X, Dai, A, Lin, G, Liu, D, Wu, F, Wu, Y, Zhao, S, Ye, L, Han, G.W, Lau, J, Wu, B, Hanson, M.A, Liu, Z.-J, Wang, M.-W, Stevens, R.C. | 登録日 | 2017-04-05 | 公開日 | 2017-05-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature, 546, 2017
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2M5Q
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8TJT
| The Fab fragment of an anti-glucagon receptor (GCGR) antibody | 分子名称: | anti-GCGR Fab heavy chain, anti-GCGR Fab light chain | 著者 | Dai, J, Carter, P.J, Sudhamsu, J, Kung, J. | 登録日 | 2023-07-24 | 公開日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG 1 antibody. Mabs, 16, 2024
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8GJI
| De novo design of high-affinity protein binders to bioactive helical peptides | 分子名称: | GCG binder, Glucagon | 著者 | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | 登録日 | 2023-03-15 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
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8YW3
| Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | 登録日 | 2024-03-29 | 公開日 | 2024-09-18 | 最終更新日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10, 2024
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8YW5
| Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex | 分子名称: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | 登録日 | 2024-03-29 | 公開日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10, 2024
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6MQ3
| Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Substrate-selective Macrocycle Inhibitor 63 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Insulin-degrading enzyme, {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol | 著者 | Tan, G.A, Seeliger, M.A, Welsh, A.J, Maianti, J.P, Liu, D.R. | 登録日 | 2018-10-09 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.569147 Å) | 主引用文献 | Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nat.Chem.Biol., 15, 2019
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7RA3
| cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP | 分子名称: | Gastric inhibitory polypeptide, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | 登録日 | 2021-06-29 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
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2RRI
| NMR structure of vasoactive intestinal peptide in DPC Micelle | 分子名称: | Vasoactive intestinal peptide | 著者 | Umetsu, Y, Tenno, T, Goda, N, Shirakawa, M, Ikegami, T, Hiroaki, H. | 登録日 | 2010-12-21 | 公開日 | 2011-04-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural difference of vasoactive intestinal peptide in two distinct membrane-mimicking environments Biochim.Biophys.Acta, 1814, 2011
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2RRH
| NMR structure of vasoactive intestinal peptide in Methanol | 分子名称: | VIP peptides | 著者 | Umetsu, Y, Tenno, T, Goda, N, Ikegami, T, Hiroaki, H. | 登録日 | 2010-11-12 | 公開日 | 2011-04-06 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural difference of vasoactive intestinal peptide in two distinct membrane-mimicking environments. Biochim.Biophys.Acta, 1814, 2011
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6BYZ
| Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Substrate-selective Macrocyclic Inhibitor 37 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALA-ALA-ALA, Insulin-degrading enzyme, ... | 著者 | Tan, G.A, Seeliger, M.A, Maianti, J.P, Liu, D.R. | 登録日 | 2017-12-21 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.95624852 Å) | 主引用文献 | Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nat.Chem.Biol., 15, 2019
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1NU6
| Crystal structure of human Dipeptidyl Peptidase IV (DPP-IV) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase IV, MERCURY (II) ION | 著者 | Hennig, M, Stihle, M, Thoma, R, Ruf, A. | 登録日 | 2003-01-31 | 公開日 | 2003-08-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Basis of Proline-Specific Exopeptidase Activity as Observed in Human Dipeptidyl Peptidase-IV. Structure, 11, 2003
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7RBT
| cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide | 分子名称: | 2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | 登録日 | 2021-07-06 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
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7C2E
| GLP-1R-Gs complex structure with a small molecule full agonist | 分子名称: | 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ma, H, Yuan, D.P, Huang, W, Wenge, Z, Xu, E. | 登録日 | 2020-05-07 | 公開日 | 2020-08-26 | 最終更新日 | 2020-12-16 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insights into the activation of GLP-1R by a small molecule agonist. Cell Res., 30, 2020
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6LPB
| Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Kobayashi, K, Shihoya, W, Nishizawa, T, Nureki, O. | 登録日 | 2020-01-09 | 公開日 | 2020-03-11 | 最終更新日 | 2020-03-25 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein. Nat.Struct.Mol.Biol., 27, 2020
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2MJ9
| Designed Exendin-4 analogues | 分子名称: | Exendin-4 | 著者 | Rovo, P, Farkas, V, Straner, P, Szabo, M, Jermendy, A, Hegyi, O, Toth, G.K, Perczel, A. | 登録日 | 2013-12-30 | 公開日 | 2014-06-04 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Rational design of alpha-helix-stabilized exendin-4 analogues. Biochemistry, 53, 2014
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