8SM7
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8S0H
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![BU of 8s0h by Molmil](/molmil-images/mine/8s0h) | A fragment-based inhibitor of SHP2 | 分子名称: | 5-(aminomethyl)-N-(3-chloranyl-1-methyl-indol-7-yl)-1,3-dihydroisoindole-2-sulfonamide, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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8RZW
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![BU of 8rzw by Molmil](/molmil-images/mine/8rzw) | A fragment-based inhibitor of SHP2 | 分子名称: | 3,5-bis(chloranyl)pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-13 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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8S0J
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![BU of 8s0j by Molmil](/molmil-images/mine/8s0j) | A fragment-based inhibitor of SHP2 | 分子名称: | 3-[3-[2,3-bis(chloranyl)phenyl]-1H-pyrrolo[3,2-b]pyridin-6-yl]propan-1-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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8S06
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![BU of 8s06 by Molmil](/molmil-images/mine/8s06) | A fragment-based inhibitor of SHP2 | 分子名称: | 1H-pyrrolo[3,2-b]pyridin-7-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-13 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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8S0P
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![BU of 8s0p by Molmil](/molmil-images/mine/8s0p) | A fragment-based inhibitor of SHP2 | 分子名称: | 1-[3-[2,3-bis(chloranyl)phenyl]-1H-pyrrolo[3,2-b]pyridin-6-yl]-4-methyl-piperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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4KI0
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![BU of 4ki0 by Molmil](/molmil-images/mine/4ki0) | Crystal structure of the maltose-binding protein/maltose transporter complex in an outward-facing conformation bound to maltohexaose | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, ABC transporter related protein, Binding-protein-dependent transport systems inner membrane component, ... | 著者 | Oldham, M.L, Chen, S, Chen, J. | 登録日 | 2013-05-01 | 公開日 | 2013-10-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Structural basis for substrate specificity in the Escherichia coli maltose transport system. Proc.Natl.Acad.Sci.USA, 110, 2013
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8S9K
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![BU of 8s9k by Molmil](/molmil-images/mine/8s9k) | Structure of dimeric FAM111A SPD S541A Mutant | 分子名称: | GLYCEROL, Serine protease FAM111A | 著者 | Palani, S, Alvey, J.A, Cong, A.T.Q, Schellenberg, M.J, Machida, Y. | 登録日 | 2023-03-29 | 公開日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes. Nat Commun, 15, 2024
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8SV9
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![BU of 8sv9 by Molmil](/molmil-images/mine/8sv9) | Crystal structure of ULK1 kinase domain with inhibitor MR-2088 | 分子名称: | (4P)-4-[(2P)-2-(1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(2,2,2-trifluoroethyl)thiophene-2-carboxamide, 1,2-ETHANEDIOL, SULFATE ION, ... | 著者 | Schonbrunn, E, Sun, L. | 登録日 | 2023-05-15 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties. Eur.J.Med.Chem., 266, 2024
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8SL4
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8SOA
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![BU of 8soa by Molmil](/molmil-images/mine/8soa) | Phosphoinositide phosphate 3 kinase gamma bound with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase | 著者 | Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2023-04-28 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
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8S04
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![BU of 8s04 by Molmil](/molmil-images/mine/8s04) | A fragment-based inhibitor of SHP2 | 分子名称: | N-(1H-indol-7-yl)methanesulfonamide, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-13 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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8SOE
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4K66
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![BU of 4k66 by Molmil](/molmil-images/mine/4k66) | Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005 complexed with avian receptor analog LSTa | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose | 著者 | Zhang, W, Shi, Y, Lu, X, Shu, Y, Qi, J, Gao, G.F. | 登録日 | 2013-04-15 | 公開日 | 2013-05-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.005 Å) | 主引用文献 | An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level. Science, 340, 2013
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8SEI
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![BU of 8sei by Molmil](/molmil-images/mine/8sei) | SF Tau from Down Syndrome | 分子名称: | Microtubule-associated protein tau | 著者 | Hoq, M.R, Bharath, S.R, Jiang, W, Vago, F.S, Bharath, S.R. | 登録日 | 2023-04-10 | 公開日 | 2024-04-03 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome. Nat.Struct.Mol.Biol., 31, 2024
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8S0K
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![BU of 8s0k by Molmil](/molmil-images/mine/8s0k) | A fragment-based inhibitor of SHP2 | 分子名称: | 3-[2,3-bis(chloranyl)phenyl]-5-methyl-6-(piperazin-1-ylmethyl)-1H-pyrrolo[3,2-b]pyridine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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8SAG
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8S0S
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![BU of 8s0s by Molmil](/molmil-images/mine/8s0s) | A fragment-based inhibitor of SHP2 | 分子名称: | (1R,5S)-8-[7-(4-chloranyl-2-methyl-indazol-5-yl)-5H-pyrrolo[2,3-b]pyrazin-3-yl]-8-azabicyclo[3.2.1]octan-3-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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8SOB
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![BU of 8sob by Molmil](/molmil-images/mine/8sob) | Phosphoinositide phosphate 3 kinase gamma bound with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase | 著者 | Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2023-04-28 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
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8SU9
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![BU of 8su9 by Molmil](/molmil-images/mine/8su9) | E. coli SIR2-HerA complex (hexamer HerA bound with dodecamer Sir2) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... | 著者 | Shen, Z.F, Lin, Q.P, Fu, T.M. | 登録日 | 2023-05-11 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8SAF
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8SO9
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![BU of 8so9 by Molmil](/molmil-images/mine/8so9) | Phosphoinositide phosphate 3 kinase gamma | 分子名称: | Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase | 著者 | Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2023-04-28 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
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8SAJ
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![BU of 8saj by Molmil](/molmil-images/mine/8saj) | Mycobacterium phage Adjutor | 分子名称: | HNH endonuclease, Major capsid protein, gp_16 (Minor Capsid Protein) | 著者 | Podgorski, J.M, White, S.J. | 登録日 | 2023-04-01 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | A novel accessory protein stabilizes the capsid of two actinobacteriophages To Be Published
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8SL3
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![BU of 8sl3 by Molmil](/molmil-images/mine/8sl3) | Human adenylyl Cyclase 5 in complex with Gbg | 分子名称: | Adenylate cyclase type 5, GERAN-8-YL GERAN, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Yen, Y.C, Tesmer, J.J.G. | 登録日 | 2023-04-20 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Structure of adenylyl cyclase 5 in complex with G beta gamma offers insights into ADCY5-related dyskinesia. Nat.Struct.Mol.Biol., 2024
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8SUW
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![BU of 8suw by Molmil](/molmil-images/mine/8suw) | E. coli SIR2-HerA complex (dodecamer SIR2 bound 4 protomers of HerA) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... | 著者 | Shen, Z.F, Lin, Q.P, Fu, T.M. | 登録日 | 2023-05-13 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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