6CLX
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![BU of 6clx by Molmil](/molmil-images/mine/6clx) | Crystal structure of TnmH in complex with SAM | 分子名称: | O-methyltransferase, S-ADENOSYLMETHIONINE | 著者 | Chang, C.Y, Annaval, T, Adhikari, A, Yan, X, Shen, B. | 登録日 | 2018-03-02 | 公開日 | 2019-03-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Characterization of TnmH as anO-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates. J.Med.Chem., 63, 2020
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5ERX
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![BU of 5erx by Molmil](/molmil-images/mine/5erx) | Crystal Structure of APO MenD from M. tuberculosis - I222 | 分子名称: | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 著者 | Johnston, J.M, Jirgis, E.N.M, Bashiri, G, Bulloch, E.M.M, Baker, E.N. | 登録日 | 2015-11-16 | 公開日 | 2016-06-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.729 Å) | 主引用文献 | Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms. Structure, 24, 2016
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6CTM
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![BU of 6ctm by Molmil](/molmil-images/mine/6ctm) | Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHCL(R-isomer), beta, gamma dTTP analogue | 分子名称: | 5'-O-[(R)-{[(R)-[(R)-chloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]thymidine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Batra, V.K, Wilson, S.H. | 登録日 | 2018-03-23 | 公開日 | 2018-06-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry, 57, 2018
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4ZU6
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![BU of 4zu6 by Molmil](/molmil-images/mine/4zu6) | Crystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus influenzae in complex with pre-reactive o-acetyl serine, alpha-aminoacrylate reaction intermediate and Peptide inhibitor at the resolution of 2.25A | 分子名称: | C-terminal peptide from Serine acetyltransferase, Cysteine synthase, O-ACETYLSERINE, ... | 著者 | Ekka, M.K, Singh, A.K, Kaushik, A, Kumaran, S. | 登録日 | 2015-05-15 | 公開日 | 2015-06-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Crystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus inuen-zae in complex with pre-reactive o-acetyl serine and peptide inhibitor To Be Published
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4ZU1
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![BU of 4zu1 by Molmil](/molmil-images/mine/4zu1) | Crystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus influenzae in complex with O-acetyl serine and peptide inhibitor | 分子名称: | C-terminal peptide from Serine acetyltransferase, Cysteine synthase, GLYCEROL, ... | 著者 | Ekka, M.K, Singh, A.K, Kaushik, A, Kumaran, S. | 登録日 | 2015-05-15 | 公開日 | 2015-06-10 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | 主引用文献 | Crystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus inuen-zae in complex with O-acetyl serine and peptide inhibitor To Be Published
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6CG3
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![BU of 6cg3 by Molmil](/molmil-images/mine/6cg3) | |
6CG5
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![BU of 6cg5 by Molmil](/molmil-images/mine/6cg5) | |
5ESQ
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![BU of 5esq by Molmil](/molmil-images/mine/5esq) | |
5EUK
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![BU of 5euk by Molmil](/molmil-images/mine/5euk) | Cetuximab Fab in complex with F3H meditope variant | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab heavy chain, Cetuximab Fab light chain, ... | 著者 | Bzymek, K.P, Williams, J.C. | 登録日 | 2015-11-18 | 公開日 | 2016-10-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5GO7
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![BU of 5go7 by Molmil](/molmil-images/mine/5go7) | Linear tri-ubiquitin | 分子名称: | D-ubiquitin, Ubiquitin | 著者 | Gao, S, Pan, M, Zheng, Y. | 登録日 | 2016-07-26 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Monomer/Oligomer Quasi-Racemic Protein Crystallography J.Am.Chem.Soc., 138, 2016
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5GOC
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![BU of 5goc by Molmil](/molmil-images/mine/5goc) | Lys11-linked diubiquitin | 分子名称: | D-ubiquitin, SODIUM ION, Ubiquitin | 著者 | Gao, S, Pan, M, Zheng, Y. | 登録日 | 2016-07-26 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.733 Å) | 主引用文献 | Monomer/Oligomer Quasi-Racemic Protein Crystallography J.Am.Chem.Soc., 138, 2016
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6CR3
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![BU of 6cr3 by Molmil](/molmil-images/mine/6cr3) | Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CBr2, beta, gamma dATP analogue | 分子名称: | 2'-deoxy-5'-O-[(R)-{[(R)-[dibromo(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]adenosine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Batra, V.K, Wilson, S.H. | 登録日 | 2018-03-16 | 公開日 | 2018-06-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry, 57, 2018
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5GQE
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![BU of 5gqe by Molmil](/molmil-images/mine/5gqe) | Crystal structure of michaelis complex of xylanase mutant (T82A, N127S, and E128H) from Streptomyces olivaceoviridis E-86 | 分子名称: | Beta-xylanase, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, ... | 著者 | Suzuki, R, Fujimoto, Z, Kaneko, S, Kuno, A. | 登録日 | 2016-08-07 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Azidolysis by the Formation of Stable Ser-His Catalytic Dyad in a Glycoside Hydrolase Family 10 Xylanase Mutant J.Appl.Glyosci., 65, 2019
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6CPM
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![BU of 6cpm by Molmil](/molmil-images/mine/6cpm) | Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | 著者 | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | 登録日 | 2018-03-13 | 公開日 | 2019-01-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | 主引用文献 | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
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5GHV
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![BU of 5ghv by Molmil](/molmil-images/mine/5ghv) | Crystal structure of an inhibitor-bound Syk | 分子名称: | 1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1H-pyrrol-3-yl}methyl)azetidin-3-ol, Tyrosine-protein kinase SYK | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | 登録日 | 2016-06-20 | 公開日 | 2016-07-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
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5CTI
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![BU of 5cti by Molmil](/molmil-images/mine/5cti) | Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a2a1a1 of type I collagen (native form) | 分子名称: | Collagen alpha-1(I) chain,Collagen alpha-1(IX) chain, Collagen alpha-1(I) chain,Collagen alpha-3(IX) chain, Collagen alpha-2(I) chain,Collagen alpha-2(IX) chain, ... | 著者 | Boudko, S.P, Bachinger, H.P. | 登録日 | 2015-07-24 | 公開日 | 2016-08-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8994 Å) | 主引用文献 | Structural insight for chain selection and stagger control in collagen. Sci Rep, 6, 2016
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6CVY
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![BU of 6cvy by Molmil](/molmil-images/mine/6cvy) | |
6CYL
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![BU of 6cyl by Molmil](/molmil-images/mine/6cyl) | |
5GNW
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![BU of 5gnw by Molmil](/molmil-images/mine/5gnw) | Crystal structure of Uracil DNA glycosylase-Uracil complex from Bradyrhizobium diazoefficiens. | 分子名称: | Blr0248 protein, URACIL | 著者 | Patil, V.V, Chembazhi, U.V, Varshney, U, Woo, E. | 登録日 | 2016-07-25 | 公開日 | 2017-06-14 | 実験手法 | X-RAY DIFFRACTION (2.869 Å) | 主引用文献 | Uracil DNA glycosylase (UDG) activities in Bradyrhizobium diazoefficiens: characterization of a new class of UDG with broad substrate specificity Nucleic Acids Res., 45, 2017
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6CTQ
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6CJJ
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![BU of 6cjj by Molmil](/molmil-images/mine/6cjj) | Candida albicans Hsp90 nucleotide binding domain in complex with ADP | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 90 homolog, ... | 著者 | Hutchinson, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, STRUCTURAL GENOMICS CONSORTIUM, S.G.C, Pizarro, J.C, Structural Genomics Consortium (SGC) | 登録日 | 2018-02-26 | 公開日 | 2019-01-30 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
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5D1L
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![BU of 5d1l by Molmil](/molmil-images/mine/5d1l) | Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (Y165A) | 分子名称: | DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, OXALATE ION, ... | 著者 | Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. | 登録日 | 2015-08-04 | 公開日 | 2015-10-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.618 Å) | 主引用文献 | Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J.Biol.Chem., 290, 2015
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5D1O
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![BU of 5d1o by Molmil](/molmil-images/mine/5d1o) | Archaeal ATP-dependent RNA ligase - form 1 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA ligase, MAGNESIUM ION, ... | 著者 | Murakami, K.S. | 登録日 | 2015-08-04 | 公開日 | 2016-03-09 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (2.648 Å) | 主引用文献 | Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis. Nucleic Acids Res., 44, 2016
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5D41
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![BU of 5d41 by Molmil](/molmil-images/mine/5d41) | EGFR kinase domain in complex with mutant selective allosteric inhibitor | 分子名称: | (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Yun, C.-H, Park, E, Eck, M.J. | 登録日 | 2015-08-07 | 公開日 | 2016-06-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature, 534, 2016
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2GUU
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![BU of 2guu by Molmil](/molmil-images/mine/2guu) | crystal structure of Plasmodium vivax orotidine 5-monophosphate decarboxylase with 6-aza-UMP bound | 分子名称: | 6-AZA URIDINE 5'-MONOPHOSPHATE, ODcase | 著者 | Dong, A, Lew, J, Zhao, Y, Sundararajan, E, Wasney, G, Vedadi, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Pai, E.F, Kotra, L, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | 登録日 | 2006-05-01 | 公開日 | 2006-05-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Crystal structure of Plasmodium vivax orotidine 5-monophosphate decarboxylase with 6-aza-UMP bound To be Published
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