8BZB
 
 | | co-soak stabilizers for ERa - 14-3-3 interaction (884_AZ275) | | 分子名称: | 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-ethoxy-1-benzothiophene-2-carboximidamide, ... | | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | | 登録日 | 2022-12-14 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8BZ0
 | | single soak stabilizer for ERa - 14-3-3 interaction (AZ275) | | 分子名称: | 14-3-3 protein sigma, 4-ethoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... | | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | | 登録日 | 2022-12-14 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8C4G
 | | Small molecule amidine soak in 14-3-3/ERa (AZ132) | | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | | 登録日 | 2023-01-03 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
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3D48
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4P8Q
 | | Crystal Structure of Human Insulin Regulated Aminopeptidase with Alanine in Active Site | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucyl-cystinyl aminopeptidase, ... | | 著者 | Hermans, S.J, Ascher, D.B, Hancock, N.C, Holien, J.K, Michell, B, Morton, C.J, Parker, M.W. | | 登録日 | 2014-03-31 | | 公開日 | 2014-12-03 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | | 主引用文献 | Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.
Protein Sci., 24, 2015
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8BZA
 | | single soak stabilizer for ERa - 14-3-3 interaction (AZ555) | | 分子名称: | 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... | | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | | 登録日 | 2022-12-14 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8CRH
 | | Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil | | 分子名称: | 5-(4-chlorophenyl)-6,6-dimethyl-1,4-dihydro-1,3,5-triazine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Kirkman, T.J, Dias, M.V.B. | | 登録日 | 2023-03-08 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris.
Acta Crystallogr D Struct Biol, 79, 2023
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8IM0
 | | mCherry-LaM8 complex | | 分子名称: | LaM8, MCherry fluorescent protein | | 著者 | Liang, H, Liu, R, Ding, Y. | | 登録日 | 2023-03-05 | | 公開日 | 2023-06-21 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies.
Int J Mol Sci, 24, 2023
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8C0K
 | | fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302) | | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | | 著者 | Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. | | 登録日 | 2022-12-17 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8BYY
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3LXO
 | | The crystal structure of ribonuclease A in complex with thymidine-3'-monophosphate | | 分子名称: | Ribonuclease pancreatic, THYMIDINE-3'-PHOSPHATE | | 著者 | Doucet, N, Jayasundera, T.B, Simonovic, M, Loria, J.P. | | 登録日 | 2010-02-25 | | 公開日 | 2010-04-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.549 Å) | | 主引用文献 | The crystal structure of ribonuclease A in complex with thymidine-3'-monophosphate provides further insight into ligand binding.
Proteins, 78, 2010
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8C04
 | | Co-soaked stabilizers for ERa - 14-3-3 interaction (884_AZ354) | | 分子名称: | 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ... | | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | | 登録日 | 2022-12-15 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8C4F
 | | Small molecule amidine soak in 14-3-3/ERa (AZ037) | | 分子名称: | 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... | | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | | 登録日 | 2023-01-03 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8IDN
 | | Cryo-EM structure of RBD/E77-Fab complex | | 分子名称: | E77 Fab heavy chain, E77 Fab light chain, Spike protein S1, ... | | 著者 | Lu, D.F, Zhang, Z.C. | | 登録日 | 2023-02-13 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | The structure of the RBD-E77 Fab complex reveals neutralization and immune escape of SARS-CoV-2.
Acta Crystallogr D Struct Biol, 79, 2023
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3CL3
 | | Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome | | 分子名称: | NF-kappa-B essential modulator, ORF K13 | | 著者 | Bagneris, C, Ageichik, A.V, Cronin, N, Boshoff, C, Waksman, G, Barrett, T. | | 登録日 | 2008-03-18 | | 公開日 | 2008-06-17 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.
Mol.Cell, 30, 2008
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3D69
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4PC6
 | | Elongation factor Tu:Ts complex with bound GDPNP | | 分子名称: | Elongation factor Ts, Elongation factor Tu, GLYCEROL, ... | | 著者 | Thirup, S.S. | | 登録日 | 2014-04-14 | | 公開日 | 2015-05-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu.
J.Struct.Biol., 191, 2015
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4PH7
 | | Structure of Osh6p in complex with phosphatidylinositol 4-phosphate | | 分子名称: | (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, Oxysterol-binding protein homolog 6 | | 著者 | Delfosse, V, Moser von Filseck, J, Antonny, B, Bourguet, W, Drin, G. | | 登録日 | 2014-05-05 | | 公開日 | 2015-07-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate.
Science, 349, 2015
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7NM3
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3D7E
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7NK5
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8BYZ
 | | fragment-linked stabilizer for ERa - 14-3-3 interaction (AZ210) | | 分子名称: | 14-3-3 protein sigma, 4-[(2~{S})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... | | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | | 登録日 | 2022-12-14 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
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5AP9
 | | Controlled lid-opening in Thermomyces lanuginosus lipase - a switch for activity and binding | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Skjold-Joergensen, J, Vind, J, Moroz, O.V, Blagova, E.V, Bhatia, V.K, Svendsen, A, Wilson, K.S, Bjerrum, M.J. | | 登録日 | 2015-09-15 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Controlled lid-opening in Thermomyces lanuginosus lipase- An engineered switch for studying lipase function.
Biochim. Biophys. Acta, 1865, 2017
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7S9Z
 | | Helicobacter Hepaticus CcsBA Closed Conformation | | 分子名称: | Cytochrome c biogenesis protein, HEME B/C, PHOSPHATIDYLETHANOLAMINE | | 著者 | Mendez, D.L, Lowder, E.P, Tillman, D.E, Sutherland, M.C, Collier, A.L, Rau, M.J, Fitzpatrick, J.A, Kranz, R.G. | | 登録日 | 2021-09-21 | | 公開日 | 2021-12-22 | | 最終更新日 | 2022-01-12 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport.
Nat.Chem.Biol., 18, 2022
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7NLE
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