PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

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5NP2	Abl1 SH3 pTyr89/134 分子名称: Tyrosine-protein kinase ABL1 著者 Mero, B, Radnai, L, Gogl, G, Leveles, I, Buday, L. 登録日 2017-04-13 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions. J.Biol.Chem., 294, 2019
5EFT	Structural Basis for Specific Recognition of ssDNA by SRBSDV P9-1 Octamers 分子名称: p9-1 著者 Li, X.Y. 登録日 2015-10-26 公開日 2016-10-26 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Specific Recognition of ssDNA by SRBSDV P9-1 Octamers To Be Published
5E7M	Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMPPNP 分子名称: ATP-dependent RNA helicase DDX3X, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Floor, S.N, Condon, K.J, Doudna, J.A. 登録日 2015-10-12 公開日 2015-12-02 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. J.Biol.Chem., 291, 2016
7TIV	Crystal structure of SARS-CoV-2 3CL in complex with inhibitor EB48 分子名称: (1S,2S)-2-[(N-{[(3-chlorophenyl)methoxy]carbonyl}-3-cyclohexyl-L-alanyl)amino]-1-hydroxy-3-[(3R)-2-oxo-2,3-dihydro-1H-pyrrol-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, MAGNESIUM ION 著者 Forouhar, F, Liu, H, Iketani, S, Zack, A, Khanizeman, N, Bednarova, E, Fowler, B, Hong, S.J, Mohri, H, Nair, M.S, Huang, Y, Tay, N.E.S, Lee, S, Karan, C, Resnick, S.J, Quinn, C, Li, W, Shion, H, Jurtschenko, C, Lauber, M.A, McDonald, T, Stokes, M.E, Hurst, B, Rovis, T, Chavez, A, Ho, D.D, Stockwell, B.R. 登録日 2022-01-14 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun, 13, 2022
7TIU	Crystal structure of SARS-CoV-2 3CL in complex with inhibitor EB46 分子名称: (1S,2S)-2-[(N-{[(3-chlorophenyl)methoxy]carbonyl}-L-leucyl)amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, MAGNESIUM ION, ... 著者 Forouhar, F, Liu, H, Iketani, S, Zack, A, Khanizeman, N, Bednarova, E, Fowler, B, Hong, S.J, Mohri, H, Nair, M.S, Huang, Y, Tay, N.E.S, Lee, S, Karan, C, Resnick, S.J, Quinn, C, Li, W, Shion, H, Jurtschenko, C, Lauber, M.A, McDonald, T, Stokes, M.E, Hurst, B, Rovis, T, Chavez, A, Ho, D.D, Stockwell, B.R. 登録日 2022-01-14 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun, 13, 2022
7TIY	Crystal structure of SARS-CoV-2 3CL in complex with inhibitor NK01-48 分子名称: (1S,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-2-[(N-{[(2,4,5-trifluorophenyl)methoxy]carbonyl}-L-leucyl)amino]propane-1-sulfonic acid, 1,2-ETHANEDIOL, 3C-like proteinase nsp5, ... 著者 Forouhar, F, Liu, H, Iketani, S, Zack, A, Khanizeman, N, Bednarova, E, Fowler, B, Hong, S.J, Mohri, H, Nair, M.S, Huang, Y, Tay, N.E.S, Lee, S, Karan, C, Resnick, S.J, Quinn, C, Li, W, Shion, H, Jurtschenko, C, Lauber, M.A, McDonald, T, Stokes, M.E, Hurst, B, Rovis, T, Chavez, A, Ho, D.D, Stockwell, B.R. 登録日 2022-01-14 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun, 13, 2022
7TIZ	Crystal structure of SARS-CoV-2 3CL in complex with inhibitor NK01-63 分子名称: (1S,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-2-{[N-({[3-(trifluoromethyl)phenyl]methoxy}carbonyl)-L-leucyl]amino}propane-1-sulfonic acid, 1,2-ETHANEDIOL, 3C-like proteinase nsp5, ... 著者 Forouhar, F, Liu, H, Iketani, S, Zack, A, Khanizeman, N, Bednarova, E, Fowler, B, Hong, S.J, Mohri, H, Nair, M.S, Huang, Y, Tay, N.E.S, Lee, S, Karan, C, Resnick, S.J, Quinn, C, Li, W, Shion, H, Jurtschenko, C, Lauber, M.A, McDonald, T, Stokes, M.E, Hurst, B, Rovis, T, Chavez, A, Ho, D.D, Stockwell, B.R. 登録日 2022-01-14 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun, 13, 2022
7TIW	Crystal structure of SARS-CoV-2 3CL in complex with inhibitor EB54 分子名称: (1S,2S)-2-[(N-{[(2-chlorophenyl)methoxy]carbonyl}-L-leucyl)amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, PHOSPHATE ION 著者 Forouhar, F, Liu, H, Iketani, S, Zack, A, Khanizeman, N, Bednarova, E, Fowler, B, Hong, S.J, Mohri, H, Nair, M.S, Huang, Y, Tay, N.E.S, Lee, S, Karan, C, Resnick, S.J, Quinn, C, Li, W, Shion, H, Jurtschenko, C, Lauber, M.A, McDonald, T, Stokes, M.E, Hurst, B, Rovis, T, Chavez, A, Ho, D.D, Stockwell, B.R. 登録日 2022-01-14 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun, 13, 2022
7TIA	Crystal structure of SARS-CoV-2 3CL in complex with inhibitor NK01-14 分子名称: 3C-like proteinase nsp5, THIOCYANATE ION, benzyl [(2S)-3-cyclopropyl-1-({(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-1-oxopropan-2-yl]carbamate 著者 Forouhar, F, Liu, H, Iketani, S, Zack, A, Khanizeman, N, Bednarova, E, Fowler, B, Hong, S.J, Mohri, H, Nair, M.S, Huang, Y, Tay, N.E.S, Lee, S, Karan, C, Resnick, S.J, Quinn, C, Li, W, Shion, H, Jurtschenko, C, Lauber, M.A, McDonald, T, Stokes, M.E, Hurst, B, Rovis, T, Chavez, A, Ho, D.D, Stockwell, B.R. 登録日 2022-01-13 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun, 13, 2022
7TIX	Crystal structure of SARS-CoV-2 3CL in complex with inhibitor EB56 分子名称: 3C-like proteinase nsp5, MAGNESIUM ION, N~2~-{[(naphthalen-2-yl)methoxy]carbonyl}-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide 著者 Forouhar, F, Liu, H, Iketani, S, Zack, A, Khanizeman, N, Bednarova, E, Fowler, B, Hong, S.J, Mohri, H, Nair, M.S, Huang, Y, Tay, N.E.S, Lee, S, Karan, C, Resnick, S.J, Quinn, C, Li, W, Shion, H, Jurtschenko, C, Lauber, M.A, McDonald, T, Stokes, M.E, Hurst, B, Rovis, T, Chavez, A, Ho, D.D, Stockwell, B.R. 登録日 2022-01-14 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun, 13, 2022
7TJ0	Crystal structure of SARS-CoV-2 3CL in complex with inhibitor SL-4-241 分子名称: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-3-cyclohexyl-L-alanyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, ACETATE ION 著者 Forouhar, F, Liu, H, Iketani, S, Zack, A, Khanizeman, N, Bednarova, E, Fowler, B, Hong, S.J, Mohri, H, Nair, M.S, Huang, Y, Tay, N.E.S, Lee, S, Karan, C, Resnick, S.J, Quinn, C, Li, W, Shion, H, Jurtschenko, C, Lauber, M.A, McDonald, T, Stokes, M, Hurst, B, Rovis, T, Chavez, A, Ho, D.D, Stockwell, B.R. 登録日 2022-01-14 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun, 13, 2022
7RAX	ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... 著者 Wang, W, Hendrickson, W.A. 登録日 2021-07-04 公開日 2023-07-05 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Conformational equilibria in allosteric control of Hsp70 chaperones. Mol.Cell, 81, 2021
1WJZ	Soluiotn structure of J-domain of mouse DnaJ like protein 分子名称: 1700030A21Rik protein 著者 Kobayashi, N, Koshiba, S, Inoue, M, Tochio, N, Tomizawa, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-05-29 公開日 2004-11-29 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Soluiotn structure of J-domain of mouse DnaJ like protein To be Published
1FAF	NMR STRUCTURE OF THE N-TERMINAL J DOMAIN OF MURINE POLYOMAVIRUS T ANTIGENS. 分子名称: LARGE T ANTIGEN 著者 Berjanskii, M.V, Riley, M.I, Xie, A, Semenchenko, V, Folk, W.R, Van Doren, S.R. 登録日 2000-07-13 公開日 2000-11-22 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR structure of the N-terminal J domain of murine polyomavirus T antigens. Implications for DnaJ-like domains and for mutations of T antigens. J.Biol.Chem., 275, 2000
6NJ5	Thermostable variant of human carbonic anhydrase II with disordered tetrazine 2.0 at site 233 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Kean, K.M, Karplus, P.A. 登録日 2019-01-02 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Immobilization of Proteins with Controlled Load and Orientation. ACS Appl Mater Interfaces, 11, 2019
6NJ4	Thermostable variant of human carbonic anhydrase with disordered tetrazine 2.0 reacted with strained trans-cyclooctene at site 233 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Kean, K.M, Karplus, P.A. 登録日 2019-01-02 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Immobilization of Proteins with Controlled Load and Orientation. ACS Appl Mater Interfaces, 11, 2019
6NJ2	thermostable carbonic anhydrase II variant with tetrazine 2.0 at site 186 分子名称: Carbonic anhydrase 2, GLYCEROL, SULFATE ION, ... 著者 Kean, K.M, Karplus, P.A. 登録日 2019-01-02 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Immobilization of Proteins with Controlled Load and Orientation. ACS Appl Mater Interfaces, 11, 2019
6NJ3	Thermostable variant of human carbonic anhydrase with ordered tetrazine 2.0 at site 233 分子名称: ACETATE ION, Carbonic anhydrase 2, ZINC ION 著者 Kean, K.M, Karplus, P.A. 登録日 2019-01-02 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.01 Å) 主引用文献 Immobilization of Proteins with Controlled Load and Orientation. ACS Appl Mater Interfaces, 11, 2019
5K8C	X-ray structure of KdnB, 3-deoxy-alpha-D-manno-octulosonate 8-oxidase, from Shewanella oneidensis 分子名称: 1,2-ETHANEDIOL, 3-deoxy-alpha-D-manno-octulosonate 8-oxidase, CHLORIDE ION, ... 著者 Holden, H.M, Thoden, J.B, Zachman-Brockmeyer, T.R. 登録日 2016-05-28 公開日 2016-06-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structures of KdnB and KdnA from Shewanella oneidensis: Key Enzymes in the Formation of 8-Amino-3,8-Dideoxy-d-Manno-Octulosonic Acid. Biochemistry, 55, 2016
6NJ6	Thermostable variant of human carbonic anhydrase with tetrazine 2.0 at site 186 reacted with sTCO in crystallo 分子名称: Carbonic anhydrase 2, GLYCEROL, METHANOL, ... 著者 Kean, K.M, Karplus, P.A. 登録日 2019-01-02 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Immobilization of Proteins with Controlled Load and Orientation. ACS Appl Mater Interfaces, 11, 2019
2CUG	Solution structure of the J domain of the pseudo DnaJ protein, mouse hypothetical mKIAA0962 分子名称: mKIAA0962 protein 著者 Ohnishi, S, Kigawa, T, Sato, M, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-26 公開日 2005-11-26 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the J domain of the pseudo DnaJ protein, mouse hypothetical mKIAA0962 To be Published
7KRU	Stimulating state of a truncated Hsp70 DnaK fused with a substrate peptide 分子名称: 1,3-PROPANDIOL, ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK fused with substrate peptide, ... 著者 Wang, W, Hendrickson, W.A. 登録日 2020-11-20 公開日 2021-09-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Conformational equilibria in allosteric control of Hsp70 chaperones. Mol.Cell, 81, 2021
7KRV	Stimulating state of disulfide-bridged Hsp70 DnaK 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK fused with substrate peptide, MAGNESIUM ION, ... 著者 Wang, W, Hendrickson, W.A. 登録日 2020-11-20 公開日 2021-09-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Conformational equilibria in allosteric control of Hsp70 chaperones. Mol.Cell, 81, 2021
1FSJ	CRYSTAL STRUCTURE OF THE E9 DNASE DOMAIN 分子名称: COLICIN E9, PHOSPHATE ION, ZINC ION 著者 Kuhlmann, U.C, Pommer, A.J, Moore, G.R, James, R, Kleanthous, C, Hemmings, A.M. 登録日 2000-09-11 公開日 2003-06-17 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of the E9 DNase domain in comparison with the inhibited structure of the E9 DNase/Im9 complex To be Published
2YS8	Solution structure of the DnaJ-like domain from human ras-associated protein Rap1 分子名称: Rab-related GTP-binding protein RabJ 著者 Ohnishi, S, Sato, M, Koshiba, S, Harada, T, Watanabe, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-03 公開日 2007-10-09 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the DnaJ-like domain from human ras-associated protein Rap1 To be Published

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