PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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5AM7	FGFR1 mutant with an inhibitor 分子名称: 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, CHLORIDE ION, FIBROBLAST GROWTH FACTOR RECEPTOR 1 著者 Bunney, T.D, Wan, S, Thiyagarajan, N, Sutto, L, Williams, S.V, Ashford, P, Koss, H, Knowles, M.A, Gervasio, F.L, Coveney, P.V, Katan, M. 登録日 2015-03-10 公開日 2015-03-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.957 Å) 主引用文献 The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study Ebiomedicine, 2, 2015
6M1H	CryoEM structure of human PAC1 receptor in complex with maxadilan 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. 登録日 2020-02-26 公開日 2020-03-11 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
6M1I	CryoEM structure of human PAC1 receptor in complex with PACAP38 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. 登録日 2020-02-26 公開日 2020-03-11 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
8I7R	In situ structure of axonemal doublet microtubules in mouse sperm with 48-nm repeat 分子名称: Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... 著者 Zhu, Y, Yin, G.L, Tai, L.H, Sun, F. 登録日 2023-02-02 公開日 2023-10-11 最終更新日 2023-12-06 実験手法 ELECTRON MICROSCOPY (6.5 Å) 主引用文献 In-cell structural insight into the stability of sperm microtubule doublet. Cell Discov, 9, 2023
8I7O	In situ structure of axonemal doublet microtubules in mouse sperm with 16-nm repeat 分子名称: Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 20, Cilia- and flagella-associated protein 276, ... 著者 Zhu, Y, Yin, G.L, Tai, L.H, Sun, F. 登録日 2023-02-01 公開日 2023-10-11 最終更新日 2023-12-06 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 In-cell structural insight into the stability of sperm microtubule doublet. Cell Discov, 9, 2023
4HWT	Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor 分子名称: N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, cytoplasmic, ... 著者 Hilgers, M.T. 登録日 2012-11-08 公開日 2013-09-18 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J.Med.Chem., 56, 2013
3NX8	human cAMP dependent protein kinase in complex with phenol 分子名称: PHENOL, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Koester, H, Heine, A, Klebe, G. 登録日 2010-07-13 公開日 2011-07-13 最終更新日 2012-02-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Experimental and computational active site mapping as a starting point to fragment-based lead discovery. Chemmedchem, 7, 2012
3QYW	Crystal structure of ERK2 in complex with an inhibitor 分子名称: 6-(3-bromophenyl)-7H-purin-2-amine, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Pochet, S, Hoh, F, Pirochi, M, Guichou, J.-F, Ferrer, J.-L, Labesse, G. 登録日 2011-03-04 公開日 2011-08-24 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 In-plate protein crystallization, in situ ligand soaking and X-ray diffraction. Acta Crystallogr.,Sect.D, 67, 2011
2VYN	Structure of E.Coli GAPDH Rat Sperm GAPDH heterotetramer 分子名称: FORMIC ACID, GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Frayne, J, Taylor, A, Hall, L, Hadfield, A. 登録日 2008-07-25 公開日 2008-08-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of Insoluble Rat Sperm Glyceraldehyde-3-Phosphate Dehydrogenase (Gapdh) Via Heterotetramer Formation with Escherichia Coli Gapdh Reveals Target for Contraceptive Design. J.Biol.Chem., 284, 2009
2VYV	Structure of E.Coli GAPDH Rat Sperm GAPDH heterotetramer 分子名称: FORMIC ACID, GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Frayne, J, Taylor, A, Hall, L, Hadfield, A. 登録日 2008-07-29 公開日 2008-08-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Structure of Insoluble Rat Sperm Glyceraldehyde-3-Phosphate Dehydrogenase (Gapdh) Via Heterotetramer Formation with Escherichia Coli Gapdh Reveals Target for Contraceptive Design. J.Biol.Chem., 284, 2009
3QYZ	Crystal structure of ERK2 in complex with an inhibitor 分子名称: 5'-azido-8-bromo-5'-deoxyadenosine, BETA-MERCAPTOETHANOL, DIMETHYL SULFOXIDE, ... 著者 Gelin, M, Pochet, S, Hoh, F, Pirochi, M, Guichou, J.-F, Ferrer, J.-L, Labesse, G. 登録日 2011-03-04 公開日 2011-08-24 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 In-plate protein crystallization, in situ ligand soaking and X-ray diffraction. Acta Crystallogr.,Sect.D, 67, 2011
3DL2	Hexagonal structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A 分子名称: PHOSPHATE ION, SODIUM ION, Ubiquitin-conjugating enzyme E2 variant 3 著者 Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Finerty Jr, P.J, Butler-Cole, C, Bountra, C, Wolkstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2008-06-26 公開日 2008-07-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Investigation Into the L-Lactate Dehydrogenase Domain of Human Ubiquitin-Conjugating Enzyme E2-Like Isoform A. To be Published
3F9K	Two domain fragment of HIV-2 integrase in complex with LEDGF IBD 分子名称: Integrase, MAGNESIUM ION, PC4 and SFRS1-interacting protein, ... 著者 Hare, S, Cherepanov, P. 登録日 2008-11-14 公開日 2009-01-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75 Plos Pathog., 5, 2009
2YI1	Crystal structure of N-Acetylmannosamine kinase in complex with N- acetyl mannosamine 6-phosphate and ADP. 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-mannopyranose, 2-acetamido-2-deoxy-alpha-D-mannopyranose, ... 著者 Martinez, J, Nguyen, L.D, Tauberger, E, Hinderlich, S, Reutter, W, Fan, H, Saenger, W, Moniot, S. 登録日 2011-05-10 公開日 2012-02-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal Structures of N-Acetylmannosamine Kinase Provide Insights Into Enzyme Specificity and Inhibition J.Biol.Chem., 287, 2012
2YHW	High-resolution crystal structures of N-Acetylmannosamine kinase: Insights about substrate specificity, activity and inhibitor modelling. 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-mannopyranose, ACETATE ION, ... 著者 Martinez, J, Nguyen, L.D, Tauberger, E, Hinderlich, S, Zimmer, R, Tauberger, E, Reutter, W, Saenger, W, Fan, H, Moniot, S. 登録日 2011-05-08 公開日 2012-02-29 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Crystal Structures of N-Acetylmannosamine Kinase Provide Insights Into Enzyme Specificity and Inhibition J.Biol.Chem., 287, 2012
2NSQ	Crystal structure of the C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein 分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase NEDD4-like protein, GLYCEROL 著者 Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2006-11-06 公開日 2006-12-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 The C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein To be Published
5WFR	Ligand-bound Ras:SOS:Ras complex 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. 登録日 2017-07-12 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
5WFP	Ligand-bound Ras:SOS:Ras complex 分子名称: 6-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... 著者 Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. 登録日 2017-07-12 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
5WFO	Ligand-bound Ras:SOS:Ras complex 分子名称: 6-chloranyl-~{N}-(4-fluorophenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... 著者 Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. 登録日 2017-07-12 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
5WFQ	Ligand-bound Ras:SOS:Ras complex 分子名称: 7-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... 著者 Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. 登録日 2017-07-12 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
4MK0	Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative 分子名称: 5-{[(3S,4R)-4-(4-fluorophenyl)piperidin-3-yl]methoxy}-1H-isoindol-1-one, Beta-adrenergic receptor kinase 1, GLYCEROL, ... 著者 Homan, K.T, Tesmer, J.J.G. 登録日 2013-09-04 公開日 2014-01-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol.Pharmacol., 85, 2014
4F65	Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 8 分子名称: 1,2-ETHANEDIOL, 5-bromo-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-N~4~-[3-(2-phenylethyl)-1H-pyrazol-5-yl]pyrimidine-2,4-diamine, Fibroblast growth factor receptor 1, ... 著者 Norman, R.A, Breed, J, Ogg, D. 登録日 2012-05-14 公開日 2012-06-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Protein-Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase. J.Med.Chem., 55, 2012
4F63	Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 1 分子名称: 1,2-ETHANEDIOL, 5-bromo-N~4~-(3-methyl-1H-pyrazol-5-yl)-N~2~-[2-(pyridin-3-yl)ethyl]pyrimidine-2,4-diamine, Fibroblast growth factor receptor 1 著者 Norman, R.A, Breed, J, Ogg, D. 登録日 2012-05-14 公開日 2012-06-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Protein-Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase. J.Med.Chem., 55, 2012
4F64	Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 6 分子名称: 1,2-ETHANEDIOL, 5-bromo-N~4~-[3-(3-methoxypropyl)-1H-pyrazol-5-yl]-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine, Fibroblast growth factor receptor 1, ... 著者 Norman, R.A, Breed, J, Ogg, D. 登録日 2012-05-14 公開日 2012-06-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Protein-Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase. J.Med.Chem., 55, 2012
1Q1V	Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif 分子名称: DEK protein 著者 Devany, M, Kotharu, N.P, Matsuo, H. 登録日 2003-07-22 公開日 2004-08-10 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution NMR structure of the C-terminal domain of the human protein DEK PROTEIN SCI., 13, 2004

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