8BUE
| Structure of DDB1 bound to Z11-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUG
| Structure of DDB1 bound to HQ461-engaged CDK12-cyclin K | 分子名称: | 2-[2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-~{N}-(5-methyl-1,3-thiazol-2-yl)ethanamide, CITRIC ACID, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8DY5
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2YB1
| Structure of an amidohydrolase from Chromobacterium violaceum (EFI target EFI-500202) with bound Mn, AMP and phosphate. | 分子名称: | ADENOSINE MONOPHOSPHATE, AMIDOHYDROLASE, MANGANESE (II) ION, ... | 著者 | Vetting, M.W, Hillerich, B, Foti, R, Seidel, R.D, Zencheck, W.D, Toro, R, Imker, H.J, Raushel, F.M, Gerlt, J.A, Almo, S.C. | 登録日 | 2011-02-25 | 公開日 | 2011-03-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | Prospecting for Unannotated Enzymes: Discovery of a 3',5'-Nucleotide Bisphosphate Phosphatase within the Amidohydrolase Superfamily. Biochemistry, 53, 2014
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8DY1
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6ZV1
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6ZV2
| TFIIS N-terminal domain (TND) from human PPP1R10 | 分子名称: | Serine/threonine-protein phosphatase 1 regulatory subunit 10 | 著者 | Veverka, V. | 登録日 | 2020-07-23 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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8BX1
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8BX2
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6ZV4
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6ZV0
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6ZUY
| Human TFIIS N-terminal domain (TND) | 分子名称: | Transcription elongation factor A protein 1 | 著者 | Veverka, V. | 登録日 | 2020-07-23 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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6UCL
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6UCI
| Transcription factor DeltaFosB bZIP domain self-assembly, oxidized form | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Protein fosB | 著者 | Yin, Z, Machius, M, Rudenko, G. | 登録日 | 2019-09-16 | 公開日 | 2020-01-15 | 最終更新日 | 2020-07-01 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Self-assembly of the bZIP transcription factor Delta FosB. Curr Res Struct Biol, 2, 2020
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8CPD
| Cryo-EM structure of CRaf dimer with 14:3:3 | 分子名称: | 14-3-3 protein zeta isoform X1, RAF proto-oncogene serine/threonine-protein kinase | 著者 | Dedden, D, Graedler, U, Schwarz, D, Thomsen, M, Leuthner, B, Schneider, E, Nitsche, J. | 登録日 | 2023-03-02 | 公開日 | 2024-02-21 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
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8CHF
| cryo-EM Structure of Craf:14-3-3:Mek1 | 分子名称: | 14-3-3 protein zeta isoform X1, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Dedden, D, Ulrich, G. | 登録日 | 2023-02-07 | 公開日 | 2024-02-21 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
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8BZO
| Cryo-EM structure of CDK2-CyclinA in complex with p27 from the SCFSKP2 E3 ligase Complex | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B | 著者 | Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E. | 登録日 | 2022-12-15 | 公開日 | 2023-06-28 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1. Sci Rep, 13, 2023
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8BYL
| Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex | 分子名称: | Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, S-phase kinase-associated protein 1, ... | 著者 | Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.M. | 登録日 | 2022-12-13 | 公開日 | 2023-06-28 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1. Sci Rep, 13, 2023
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5TCX
| Crystal structure of human tetraspanin CD81 | 分子名称: | CD81 antigen, CHOLESTEROL | 著者 | Zimmerman, B, McMillan, B.J, Seegar, T.C.M, Kruse, A.C, Blacklow, S.C. | 登録日 | 2016-09-16 | 公開日 | 2016-11-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.955 Å) | 主引用文献 | Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell, 167, 2016
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8CDN
| Crystal structure of human Brachyury in complex with a single T box binding element DNA | 分子名称: | DNA (5'-D(*AP*GP*GP*CP*TP*CP*AP*CP*AP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*TP*GP*TP*GP*AP*GP*CP*CP*T)-3'), T-box transcription factor T | 著者 | Newman, J.A, Gavard, A.E, von Delft, F, Gileadi, O, Bountra, C. | 登録日 | 2023-01-31 | 公開日 | 2023-03-22 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Crystal structure of human Brachyury in complex with a single T box binding element DNA To Be Published
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7E4K
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1H4X
| Structure of the Bacillus Cell Fate Determinant SpoIIAA in the Phosphorylated Form | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ANTI-SIGMA F FACTOR ANTAGONIST | 著者 | Seavers, P.R, Lewis, R.J, Brannigan, J.A, Verschueren, K.H.G, Murshudov, G.N, Wilkinson, A.J. | 登録日 | 2001-05-15 | 公開日 | 2001-07-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | 主引用文献 | Structure of the Bacillus Cell Fate Determinant Spoiiaa in Phosphorylated and Unphosphorylated Forms Structure, 9, 2001
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8CO6
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8C3C
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8C2G
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