PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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1FIL	HUMAN PLATELET PROFILIN I CRYSTALLIZED IN HIGH SALT ACTIN-BINDING PROTEIN 分子名称: PROFILIN, SULFATE ION 著者 Fedorov, A.A, Pollard, T.D, Almo, S.C. 登録日 1996-04-29 公開日 1996-11-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Human Profilin at 2.0 Angstroms Resolution To be Published
2JX8	Solution structure of hPCIF1 WW domain 分子名称: Phosphorylated CTD-interacting factor 1 著者 Kouno, T, Iwamoto, Y, Hirose, Y, Aizawa, T, Demura, M, Kawano, K, Ohkuma, Y, Mizuguchi, M. 登録日 2007-11-09 公開日 2008-11-11 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 1H, 13C, and 15N resonance assignments of hPCIF1 WW domain To be Published
1TRS	THE HIGH-RESOLUTION THREE-DIMENSIONAL SOLUTION STRUCTURES OF THE OXIDIZED AND REDUCED STATES OF HUMAN THIOREDOXIN 分子名称: THIOREDOXIN 著者 Clore, G.M, Qin, J, Gronenborn, A.M. 登録日 1994-05-10 公開日 1994-09-30 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin. Structure, 2, 1994
7CBT	The crystal structure of SARS-CoV-2 main protease in complex with GC376 分子名称: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase 著者 Shi, Y, Peng, G. 登録日 2020-06-13 公開日 2020-09-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.346 Å) 主引用文献 The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract. Emerg Microbes Infect, 10, 2021
6UCM	Transcription factor DeltaFosB bZIP domain self-assembly, type-II crystal 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Protein fosB 著者 Yin, Z, Machius, M, Rudenko, G. 登録日 2019-09-16 公開日 2020-01-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.424 Å) 主引用文献 Self-assembly of the bZIP transcription factor Delta FosB. Curr Res Struct Biol, 2, 2020
8BYE	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075313) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclobutane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYB	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074398) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWJ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074386) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-2-[4-(trifluoromethyl)phenoxy]propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-06 公開日 2023-08-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWZ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074393) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-ethanoylphenoxy)-2-methyl-propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX4	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074392) 分子名称: 14-3-3 protein sigma, 2-[3,4-bis(chloranyl)phenoxy]-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
6UJA	Integrin alpha-v beta-8 in complex with pro-TGF-beta1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. 登録日 2019-10-02 公開日 2020-02-05 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
8BYF	fragment-linked stabilizer for ERa - 14-3-3 interaction (1047455) 分子名称: 14-3-3 protein sigma, PHE-PRO-ALA-TPO-VAL, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-chloranylphenoxy)-2-methyl-propanamide 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXO	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075287) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4,4-bis(fluoranyl)-1-phenoxy-cyclohexane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXQ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075296) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-phenoxy-cyclohexane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXS	Fragment-linked stabilizer for ERa - 14-3-3 interaction (1075293) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-(4-chloranylphenoxy)oxane-4-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BY9	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075292) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)-4,4-bis(fluoranyl)cyclohexane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX3	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074372) 分子名称: 14-3-3 protein sigma, 2-(4-bromanylphenoxy)-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXI	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-08 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXN	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074399) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-phenoxy-oxane-4-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYD	fragment-linked stabilizer for ERa - 14-3-3 interactions (1075288) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclopentane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX0	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074388) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-methoxyphenoxy)-2-methyl-propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWX	Fragment-linked stabilizer for 14-3-3 and ERa (1075298) 分子名称: 14-3-3 protein sigma, 4-azanyl-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide, ERalpha peptide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXM	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074397) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYC	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075316) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BUM	Structure of DDB1 bound to DS15-engaged CDK12-cyclin K 分子名称: (2R)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-20 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024

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