PDB: 226262 件ウェブページステータス検索Chemie searchBIRD

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4V5J	Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release 分子名称: 16S Ribosomal RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... 著者 Jin, H, Kelley, A.C, Loakes, D, Ramakrishnan, V. 登録日 2010-03-24 公開日 2014-07-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release. Proc. Natl. Acad. Sci. U.S.A., 107, 2010
5SOV	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ZINC000893191027 - (S) and (R) isomers 分子名称: 5-ethyl-4-[(3R)-3-(methylsulfonyl)piperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine, 5-ethyl-4-[(3S)-3-(methylsulfonyl)piperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine, Non-structural protein 3 著者 Correy, G.J, Fraser, J.S. 登録日 2022-06-09 公開日 2022-07-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
4V7Y	Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin. 分子名称: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. 登録日 2010-08-18 公開日 2014-07-09 最終更新日 2014-12-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc.Natl.Acad.Sci.USA, 107, 2010
2STB	ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA PEPO TRYPSIN INHIBITOR II) 分子名称: CALCIUM ION, PROTEIN (TRYPSIN INHIBITOR), PROTEIN (TRYPSIN) 著者 Helland, R, Berglund, G.I, Otlewski, J, Apostoluk, W, Andersen, O.A, Willassen, N.P, Smalas, A.O. 登録日 1998-12-11 公開日 2000-01-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes. Acta Crystallogr.,Sect.D, 55, 1999
5SRA	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with Z5372052920 - (R) isomer 分子名称: (2R)-4-(7-fluoro-9H-pyrimido[4,5-b]indol-4-yl)morpholine-2-carboxylic acid, Non-structural protein 3 著者 Correy, G.J, Fraser, J.S. 登録日 2022-06-09 公開日 2022-07-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
8H59	A fungal MAP kinase in complex with an inhibitor 分子名称: Mitogen-activated protein kinase MPS1, ~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]-8-[2-methoxy-5-(trifluoromethyloxy)phenyl]-1,6-naphthyridine-2-carboxamide 著者 Kong, Z, Zhang, X, Wang, D, Liu, J. 登録日 2022-10-12 公開日 2023-02-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi. Mbio, 14, 2023
5SR9	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with Z3562259556 - (R) isomer 分子名称: Non-structural protein 3, methyl (3R)-1-(7-fluoro-9H-pyrimido[4,5-b]indol-4-yl)-3-(hydroxymethyl)pyrrolidine-3-carboxylate 著者 Correy, G.J, Fraser, J.S. 登録日 2022-06-09 公開日 2022-07-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
2THF	STRUCTURE OF HUMAN ALPHA-THROMBIN Y225F MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE 分子名称: D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SODIUM ION, THROMBIN HEAVY CHAIN, ... 著者 Caccia, S, Futterer, K, Di Cera, E, Waksman, G. 登録日 1999-01-26 公開日 1999-03-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Unexpected crucial role of residue 225 in serine proteases. Proc.Natl.Acad.Sci.USA, 96, 1999
8H9B	Crystal structure of chemically modified E. coli ThrS catalytic domain 3 分子名称: N-(2,3-dihydroxybenzoyl)-4-(4-nitrophenyl)-L-threonine, Threonine--tRNA ligase, ZINC ION 著者 Qiao, H, Xia, M, Wang, J, Fang, P. 登録日 2022-10-25 公開日 2023-02-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion. Commun Biol, 6, 2023
4V9F	The re-refined crystal structure of the Haloarcula marismortui large ribosomal subunit at 2.4 Angstrom resolution: more complete structure of the L7/L12 and L1 stalk, L5 and LX proteins 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L10E, 50S ribosomal protein L10e, ... 著者 Gabdulkhakov, A. 登録日 2012-11-02 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.404 Å) 主引用文献 Revisiting the Haloarcula marismortui 50S ribosomal subunit model. Acta Crystallogr.,Sect.D, 69, 2013
5SRC	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with Z5198562500 - (R,R) and (R,S) isomers 分子名称: (2R)-[(3R)-1-(7-fluoro-9H-pyrimido[4,5-b]indol-4-yl)piperidin-3-yl](hydroxy)acetic acid, (2S)-[(3R)-1-(7-fluoro-9H-pyrimido[4,5-b]indol-4-yl)piperidin-3-yl](hydroxy)acetic acid, Non-structural protein 3 著者 Correy, G.J, Fraser, J.S. 登録日 2022-06-09 公開日 2022-07-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
2RC9	Crystal structure of the NR3A ligand binding core complex with ACPC at 1.96 Angstrom resolution 分子名称: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, Glutamate [NMDA] receptor subunit 3A 著者 Yao, Y, Mayer, M.L. 登録日 2007-09-19 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. Embo J., 27, 2008
8HHZ	SARS-CoV-2 Omicron BA.1 Spike in complex with IY-2A 分子名称: IY-2A Fab heavy chain, IY-2A Fab light chain, Spike glycoprotein 著者 Chen, X, Mohapatra, A, Wu, Y.-M. 登録日 2022-11-17 公開日 2023-02-01 実験手法 ELECTRON MICROSCOPY (4.28 Å) 主引用文献 Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2. Nat Commun, 14, 2023
4WDG	Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation V321A, complexed with 2',5'-ADP 分子名称: 2',3'-cyclic-nucleotide 3'-phosphodiesterase, ADENOSINE-2'-5'-DIPHOSPHATE 著者 Myllykoski, M, Raasakka, A, Kursula, P. 登録日 2014-09-08 公開日 2015-09-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase. Sci Rep, 5, 2015
5SON	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ZINC000920153280 - (R) isomer 分子名称: 3-{[(2R)-2-phenylpropyl]sulfanyl}-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazole, Non-structural protein 3 著者 Correy, G.J, Fraser, J.S. 登録日 2022-06-09 公開日 2022-07-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
8H8J	Lodoxamide-bound GPR35 in complex with G13 分子名称: 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid), CALCIUM ION, CHOLESTEROL, ... 著者 Yuan, Q, Duan, J, Liu, Q, Xu, H.E, Jiang, Y. 登録日 2022-10-23 公開日 2023-02-08 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell Discov, 8, 2022
8HHO	cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP 分子名称: Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. 登録日 2022-11-16 公開日 2023-02-08 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy. Febs J., 290, 2023
4WE0	JC Polyomavirus VP1 five-fold pore mutant P223M 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Major capsid protein VP1 著者 Stroh, L.J, Stehle, T. 登録日 2014-09-09 公開日 2015-02-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Modulation of a Pore in the Capsid of JC Polyomavirus Reduces Infectivity and Prevents Exposure of the Minor Capsid Proteins. J.Virol., 89, 2015
5SOS	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ZINC000559260078 分子名称: 3-[(5-chloropyridin-2-yl)methyl]-3H-purin-6-amine, Non-structural protein 3 著者 Correy, G.J, Fraser, J.S. 登録日 2022-06-09 公開日 2022-07-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
4UQI	AP2 controls clathrin polymerization with a membrane-activated switch 分子名称: AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2 COMPLEX SUBUNIT BETA, AP-2 COMPLEX SUBUNIT MU, ... 著者 Kelly, B.T, Graham, S.C, Liska, N, Dannhauser, P.N, Hoening, S, Ungewickell, E.J, Owen, D.J. 登録日 2014-06-23 公開日 2014-07-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Clathrin Adaptors. Ap2 Controls Clathrin Polymerization with a Membrane-Activated Switch. Science, 345, 2014
2TMV	VISUALIZATION OF PROTEIN-NUCLEIC ACID INTERACTIONS IN A VIRUS. REFINED STRUCTURE OF INTACT TOBACCO MOSAIC VIRUS AT 2.9 ANGSTROMS RESOLUTION BY X-RAY FIBER DIFFRACTION 分子名称: CALCIUM ION, RNA (5'-R(P*GP*AP*A)-3'), TMV COAT PROTEIN 著者 Stubbs, G, Pattanayek, R, Namba, K. 登録日 1988-09-15 公開日 1989-01-09 最終更新日 2024-02-21 実験手法 FIBER DIFFRACTION (2.9 Å) 主引用文献 Visualization of protein-nucleic acid interactions in a virus. Refined structure of intact tobacco mosaic virus at 2.9 A resolution by X-ray fiber diffraction. J.Mol.Biol., 208, 1989
5SOW	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ZINC000118179920 分子名称: 1-{2-[(9H-purin-6-yl)sulfanyl]ethyl}pyrrolidin-2-one, Non-structural protein 3 著者 Correy, G.J, Fraser, J.S. 登録日 2022-06-09 公開日 2022-07-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
8HIQ	cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP 分子名称: Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. 登録日 2022-11-21 公開日 2023-02-08 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy. Febs J., 290, 2023
5SRD	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with Z5373433723 - (S) isomer 分子名称: (8S)-8-fluoro-6-(7-fluoro-9H-pyrimido[4,5-b]indol-4-yl)-N-(methanesulfonyl)-6-azaspiro[3.4]octane-8-carboxamide, Non-structural protein 3 著者 Correy, G.J, Fraser, J.S. 登録日 2022-06-09 公開日 2022-07-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
2TPK	AN INVESTIGATION OF THE STRUCTURE OF THE PSEUDOKNOT WITHIN THE GENE 32 MESSENGER RNA OF BACTERIOPHAGE T2 USING HETERONUCLEAR NMR METHODS 分子名称: RNA (MRNA PSEUDOKNOT) 著者 Holland, J.A, Hansen, M.R, Du, Z, Hoffman, D.W. 登録日 1998-10-28 公開日 1998-11-04 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 An examination of coaxial stacking of helical stems in a pseudoknot motif: the gene 32 messenger RNA pseudoknot of bacteriophage T2. Rna, 5, 1999

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