8C3A
 
 | | Crystal structure of ailanthone bound to the Candida albicans 80S ribosome | | 分子名称: | 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | | 著者 | Kolosova, O, Zgadzay, Y, Yusupov, M. | | 登録日 | 2022-12-23 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | New crystal system to promote screening for new eukaryotic inhibitors
To Be Published
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6J4W
 | | RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-5) of the nucleosome | | 分子名称: | DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S. | | 登録日 | 2019-01-10 | | 公開日 | 2019-02-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | | 主引用文献 | Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
Science, 363, 2019
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5POP
 | | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10987a | | 分子名称: | 1,2-ETHANEDIOL, 1-[4-(pyridin-4-yl)piperazin-1-yl]ethan-1-one, Bromodomain-containing protein 1, ... | | 著者 | Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | 登録日 | 2017-02-07 | | 公開日 | 2017-03-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.579 Å) | | 主引用文献 | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
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8CRO
 | | Cryo-EM structure of Pyrococcus furiosus transcription elongation complex | | 分子名称: | DNA Non-Template Strand, DNA Template Strand, DNA-directed RNA polymerase subunit Rpo10, ... | | 著者 | Tarau, D.M, Grunberger, F, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. | | 登録日 | 2023-03-08 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment.
Nucleic Acids Res., 52, 2024
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5POQ
 | | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10974a | | 分子名称: | 1,2-ETHANEDIOL, 1-[4-(methylsulfonyl)piperazin-1-yl]ethan-1-one, Bromodomain-containing protein 1, ... | | 著者 | Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | 登録日 | 2017-02-07 | | 公開日 | 2017-03-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
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5PO9
 | | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N07950b | | 分子名称: | 1,2-ETHANEDIOL, 1-methyl-4-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine, Bromodomain-containing protein 1, ... | | 著者 | Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | 登録日 | 2017-02-07 | | 公開日 | 2017-03-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.116 Å) | | 主引用文献 | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
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5Q1J
 | | PanDDA analysis group deposition -- Crystal Structure of DCLRE1A in complex with FMSOA000341b | | 分子名称: | DNA cross-link repair 1A protein, MALONATE ION, N-(2-hydroxyphenyl)acetamide, ... | | 著者 | Newman, J.A, Aitkenhead, H, Lee, S.Y, Kupinska, K, Burgess-Brown, N, Tallon, R, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | | 登録日 | 2017-05-15 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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5PO2
 | | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10132a | | 分子名称: | 1,2-ETHANEDIOL, 5-hydroxy-1,3-dihydro-2H-indol-2-one, Bromodomain-containing protein 1, ... | | 著者 | Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | 登録日 | 2017-02-07 | | 公開日 | 2017-03-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
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5N61
 | | RNA polymerase I initially transcribing complex | | 分子名称: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | 著者 | Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. | | 登録日 | 2017-02-14 | | 公開日 | 2017-04-05 | | 最終更新日 | 2019-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural Basis of RNA Polymerase I Transcription Initiation.
Cell, 169, 2017
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5PO6
 | | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10157a | | 分子名称: | 1,2-ETHANEDIOL, 4-(4-bromophenyl)-1H-pyrazol-3-amine, Bromodomain-containing protein 1, ... | | 著者 | Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | 登録日 | 2017-02-07 | | 公開日 | 2017-03-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
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5POO
 | | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10966a | | 分子名称: | 1,2-ETHANEDIOL, 6-(4-acetylpiperazin-1-yl)pyridine-3-carbonitrile, Bromodomain-containing protein 1, ... | | 著者 | Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | 登録日 | 2017-02-07 | | 公開日 | 2017-03-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | | 主引用文献 | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
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5POW
 | | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10894b | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 1, N-[(pyridin-2-yl)methyl]acetamide, ... | | 著者 | Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | 登録日 | 2017-02-07 | | 公開日 | 2017-03-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.768 Å) | | 主引用文献 | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
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5NL0
 | | Crystal structure of a 197-bp palindromic 601L nucleosome in complex with linker histone H1 | | 分子名称: | DNA (197-MER), Histone H1.0-B, Histone H2A type 1, ... | | 著者 | Garcia-Saez, I, Petosa, C, Dimitrov, S. | | 登録日 | 2017-04-03 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (5.4 Å) | | 主引用文献 | Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1.
Mol. Cell, 66, 2017
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8UKZ
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8D8K
 | | Yeast mitochondrial small subunit assembly intermediate (State 2) | | 分子名称: | 15S ribosomal RNA, 37S ribosomal protein MRP1, mitochondrial, ... | | 著者 | Burnside, C, Harper, N.J, Klinge, S. | | 登録日 | 2022-06-08 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Principles of mitoribosomal small subunit assembly in eukaryotes.
Nature, 614, 2023
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8D8J
 | | Yeast mitochondrial small subunit assembly intermediate (State 1) | | 分子名称: | 15S ribosomal RNA, 37S ribosomal protein MRP13, mitochondrial, ... | | 著者 | Burnside, C, Harper, N, Klinge, S. | | 登録日 | 2022-06-08 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Principles of mitoribosomal small subunit assembly in eukaryotes.
Nature, 614, 2023
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8CVM
 | | Cutibacterium acnes 50S ribosomal subunit with P-site tRNA and Sarecycline bound in the local refined map | | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | | 著者 | Lomakin, I.B, Devarkar, S.C, Bunick, C.G. | | 登録日 | 2022-05-18 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | | 主引用文献 | Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Nucleic Acids Res., 51, 2023
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5N5Y
 | | Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation III) | | 分子名称: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | 著者 | Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. | | 登録日 | 2017-02-14 | | 公開日 | 2017-04-05 | | 最終更新日 | 2018-10-03 | | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | | 主引用文献 | Structural Basis of RNA Polymerase I Transcription Initiation.
Cell, 169, 2017
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8W9E
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8W9F
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8W9D
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1W00
 | | Crystal structure of mutant enzyme D103L of Ketosteroid Isomerase from Pseudomonas putida biotype B | | 分子名称: | STEROID DELTA-ISOMERASE | | 著者 | Kim, D.H, Jang, D.S, Nam, G.H, Oh, B.H, Choi, K.Y. | | 登録日 | 2004-05-30 | | 公開日 | 2005-05-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Double-Mutant Cycle Analysis of a Hydrogen Bond Network in Ketosteroid Isomerase from Pseudomonas Putida Biotype B
Biochem.J., 382, 2004
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1W02
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5MEI
 | | Crystal structure of Agelastatin A bound to the 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | McClary, B, Zinshteyn, B, Meyer, M, Jouanneau, M, Pellegrino, S, Yusupova, G, Schuller, A, Reyes, J.C.P, Lu, J, Luo, C, Dang, Y, Romo, D, Yusupov, M, Green, R, Liu, J.O. | | 登録日 | 2016-11-15 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Cell Chem Biol, 24, 2017
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1VZZ
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