PDB: 86 件ウェブページステータス検索Chemie searchBIRD

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7XUD	Structure of G9a in complex with compound 26a 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Niwa, H, Shirai, F, Sato, S, Nishigaya, Y, Umehara, T. 登録日 2022-05-18 公開日 2023-03-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents. J.Med.Chem., 66, 2023
7XUB	Structure of G9a in complex with compound 10d 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Histone-lysine N-methyltransferase EHMT2, ... 著者 Niwa, H, Shirai, F, Sato, S, Nishigaya, Y, Umehara, T. 登録日 2022-05-18 公開日 2023-03-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents. J.Med.Chem., 66, 2023
7XUA	Structure of G9a in complex with compound 10a 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Histone-lysine N-methyltransferase EHMT2, ... 著者 Niwa, H, Shirai, F, Sato, S, Nishigaya, Y, Umehara, T. 登録日 2022-05-18 公開日 2023-03-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents. J.Med.Chem., 66, 2023
7XUC	Structure of G9a in complex with compound 11a 分子名称: 1,2-ETHANEDIOL, 3,6,6-trimethyl-4-oxidanylidene-~{N}-[(2~{S})-1-oxidanylidene-1-phenylazanyl-hexan-2-yl]-5,7-dihydro-1~{H}-indole-2-carboxamide, CHLORIDE ION, ... 著者 Niwa, H, Shirai, F, Sato, S, Nishigaya, Y, Umehara, T. 登録日 2022-05-18 公開日 2023-03-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents. J.Med.Chem., 66, 2023
6ASZ	Chromodomain HP1 with Y24F mutation bound to histone H3 peptide containing trimethyl lysine 分子名称: Heterochromatin protein 1, trimethyl lysine histone H3 tail peptide 著者 Brustad, E.M, Baril, S.A, Waters, M.L. 登録日 2017-08-27 公開日 2017-12-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.518 Å) 主引用文献 Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis. J. Am. Chem. Soc., 139, 2017
5YY9	Crystal structure of Tandem Tudor Domain of human UHRF1 in complex with LIG1-K126me3 分子名称: E3 ubiquitin-protein ligase UHRF1, Ligase 1 著者 Kori, S, Defossez, P.A, Arita, K. 登録日 2017-12-08 公開日 2018-12-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.653 Å) 主引用文献 Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure, 27, 2019
6AT0	Chromodomain HP1 with a p-nitro-L-phenylalanine mutation at position 24 bound to histone H3 peptide containing trimethyl lysine 分子名称: Heterochromatin protein 1, trimethyl lysine histone H3 tail peptide 著者 Brustad, E.M, Baril, S.A, Waters, M.L. 登録日 2017-08-27 公開日 2017-12-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.285 Å) 主引用文献 Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis. J. Am. Chem. Soc., 139, 2017
6A5M	Crystal structure of Arabidopsis thaliana SUVH6 in complex with SAM, form 2 分子名称: Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, S-ADENOSYLMETHIONINE, ... 著者 Li, X, Du, J. 登録日 2018-06-24 公開日 2018-08-29 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6A5N	Crystal structure of Arabidopsis thaliana SUVH6 in complex with methylated DNA 分子名称: DNA (5'-D(*CP*AP*CP*TP*GP*CP*TP*GP*AP*GP*TP*AP*CP*T)-3'), DNA (5'-D(*GP*AP*GP*TP*AP*CP*TP*(5CM)P*AP*GP*CP*AP*GP*T)-3'), Histone-lysine N-methyltransferase, ... 著者 Li, X, Du, J. 登録日 2018-06-24 公開日 2018-08-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6A5K	Crystal structure of Arabidopsis thaliana SUVH6 in complex with SAM, form 1 分子名称: Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, S-ADENOSYLMETHIONINE, ... 著者 Li, X, Du, J. 登録日 2018-06-24 公開日 2018-08-29 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YYA	Crystal structure of Tandem Tudor Domain of human UHRF1 分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, SULFATE ION 著者 Kori, S, Defossez, P.A, Arita, K. 登録日 2017-12-08 公開日 2018-12-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure, 27, 2019

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