PDB: 47720 件ウェブページステータス検索Chemie searchBIRD

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1QJA	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) 分子名称: 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE 著者 Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. 登録日 1999-06-23 公開日 1999-09-15 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
5N5T	14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV2 分子名称: 14-3-3 protein sigma, 4-[3,5-bis(chloranyl)pyridin-2-yl]oxyphenol, CHLORIDE ION, ... 著者 Sijbesma, E, Leysen, S, Ottmann, C. 登録日 2017-02-14 公開日 2017-07-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
5N5W	14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV3 分子名称: 14-3-3 protein sigma, 4-[3,5-bis(chloranyl)pyridin-2-yl]oxyaniline, CALCIUM ION, ... 著者 Sijbesma, E, Leysen, S, Ottmann, C. 登録日 2017-02-14 公開日 2017-07-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
5N75	14-3-3 sigma in complex with TAZ pS89 peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Sijbesma, E, Leysen, S, Ottmann, C. 登録日 2017-02-19 公開日 2017-07-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.803 Å) 主引用文献 Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
5N5R	14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV1 分子名称: 14-3-3 protein sigma, 2-azanyl-~{N}-(2,6-dimethylphenyl)-~{N}-propan-2-yl-ethanamide, CHLORIDE ION, ... 著者 Sijbesma, E, Leysen, S, Ottmann, C. 登録日 2017-02-14 公開日 2017-07-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
1A4O	14-3-3 PROTEIN ZETA ISOFORM 分子名称: 14-3-3 PROTEIN ZETA 著者 Liu, D, Bienkowska, J, Petosa, C, Collier, R.J, Fu, H, Liddington, R.C. 登録日 1998-02-01 公開日 1999-03-02 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the zeta isoform of the 14-3-3 protein. Nature, 376, 1995
2BQ0	14-3-3 Protein Beta (Human) 分子名称: 14-3-3 BETA/ALPHA 著者 Yang, X, Elkins, J.M, Fedorov, O, Longman, E.J, Sobott, L, Ball, L.J, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A. 登録日 2005-04-26 公開日 2005-05-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
4IEA	14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide 分子名称: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase 著者 Molzan, M, Ottmann, C. 登録日 2012-12-13 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. Acs Chem.Biol., 8, 2013
1QJB	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1) 分子名称: 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE 著者 Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. 登録日 1999-06-23 公開日 1999-09-15 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
6ZFD	14-3-3 zeta bound to the phosphorylated 18E6 C-terminus 分子名称: 14-3-3 protein zeta/delta,Protein E6, GLYCEROL 著者 Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. 登録日 2020-06-17 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
5MHC	Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, LYS-LEU-MET-PHE-LYS-TPO-GLU-GLY-PRO-ASP-SER-ASP, ... 著者 Andrei, S, Ottmann, C, Leysen, S. 登録日 2016-11-24 公開日 2017-10-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591, 2017
5MOC	Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Andrei, S, Ottmann, C, Leysen, S. 登録日 2016-12-14 公開日 2017-10-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591, 2017
5MXO	Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide stabilized by Fusicoccin-A 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... 著者 Andrei, S, Ottmann, C, Leysen, S. 登録日 2017-01-24 公開日 2017-11-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591, 2017
4JDD	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface 分子名称: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN 著者 Bier, D, Ottmann, C. 登録日 2013-02-25 公開日 2013-05-15 最終更新日 2017-06-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
3MHR	14-3-3 sigma in complex with YAP pS127-peptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Schumacher, B, Skwarczynska, M, Rose, R, Ottmann, C. 登録日 2010-04-08 公開日 2010-09-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Structure of a 14-3-3[sigma]-YAP phosphopeptide complex at 1.15 A resolution Acta Crystallogr.,Sect.F, 66, 2010
4JC3	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface 分子名称: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION 著者 Bier, D, Ottmann, C. 登録日 2013-02-21 公開日 2013-05-15 最終更新日 2017-06-07 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
5FRB	Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with a tetrazole-based inhibitor VT-1598 分子名称: (R)-4-((4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)ethynyl)phenoxy)methyl)benzonitrile, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-ALPHA DEMETHYLASE, ... 著者 Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. 登録日 2015-12-16 公開日 2017-04-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14 alpha-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity. Antimicrob. Agents Chemother., 61, 2017
7AEW	14-3-3 sigma bound to bis-phosphorylated aminopeptidase N (APN, CD13) via canonical and non-canonical binding motifs 分子名称: 14-3-3 protein sigma, Aminopeptidase N, CHLORIDE ION, ... 著者 Kiehstaller, S, Hennig, S. 登録日 2020-09-18 公開日 2020-11-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 MMP activation-associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J.Biol.Chem., 295, 2020
5TZ1	Crystal structure of sterol 14-alpha demethylase (CYP51) from Candida albicans in complex with the tetrazole-based antifungal drug candidate VT1161 (VT1) 分子名称: (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, PROTOPORPHYRIN IX CONTAINING FE, Sterol 14-alpha demethylase 著者 Hargrove, T, Wawrzak, Z, Lepesheva, G. 登録日 2016-11-21 公開日 2017-03-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. J. Biol. Chem., 292, 2017
7AXN	14-3-3 sigma in complex with Pin1 binding site pS72 and covalently bound TCF521-026 分子名称: 14-3-3 protein sigma, 3-chloranyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Ottmann, C. 登録日 2020-11-10 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AYF	14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-110 分子名称: 14-3-3 protein sigma, 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Ottmann, C. 登録日 2020-11-12 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.752 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AOG	14-3-3 sigma in complex with Pin1 binding site pS72 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-10-14 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
8EQH	The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y213 分子名称: 14-3-3 protein beta/alpha 著者 Zhu, P, Cooley, R.B. 登録日 2022-10-07 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. Protein Sci., 32, 2023
8C3Z	14-3-3sigma bound to strep-tagged PKA-responsive ERa phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C40	14-3-3sigma bound to PKA-responsive ERa phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen Receptor alpha phosphopeptide, MAGNESIUM ION 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023

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