PDB: 71589 件ウェブページステータス検索Chemie searchBIRD

---

6NY4	Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor 分子名称: 4-{[(2R,3R)-1,3-dihydroxybutan-2-yl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide, Tyrosine-protein kinase JAK3 著者 Sack, J.S. 登録日 2019-02-11 公開日 2019-05-22 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. Acs Med.Chem.Lett., 10, 2019
4DR4	Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, cognate transfer RNA anticodon stem-loop and multiple copies of paromomycin molecules bound 分子名称: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... 著者 Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. 登録日 2012-02-16 公開日 2012-11-14 最終更新日 2013-01-30 実験手法 X-RAY DIFFRACTION (3.969 Å) 主引用文献 A structural basis for streptomycin-induced misreading of the genetic code. Nat Commun, 4, 2013
4GWQ	Structure of the Mediator Head Module from S. cerevisiae in complex with the carboxy-terminal domain (CTD) of RNA Polymerase II Rpb1 subunit 分子名称: DNA-directed RNA polymerase II subunit RPB1, Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, ... 著者 Robinson, P.J.J, Bushnell, D.A, Trnka, M.J, Burlingame, A.L, Kornberg, R.D. 登録日 2012-09-03 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II. Proc.Natl.Acad.Sci.USA, 109, 2012
4GZ6	Crystal structure of human O-GlcNAc Transferase with UDP-5SGlcNAc 分子名称: (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, SULFATE ION, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 著者 Lazarus, M.B, Jiang, J, Gloster, T.M, Zandberg, W.F, Vocadlo, D.J, Walker, S. 登録日 2012-09-06 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat.Chem.Biol., 8, 2012
4DHI	Structure of C. elegans OTUB1 bound to human UBC13 分子名称: Ubiquitin thioesterase otubain-like, Ubiquitin-conjugating enzyme E2 N 著者 Wiener, R, Zhang, X, Wang, T, Wolberger, C. 登録日 2012-01-27 公開日 2012-02-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature, 483, 2012
4H2I	Human ecto-5'-nucleotidase (CD73): crystal form III (closed) in complex with AMPCP 分子名称: 5'-nucleotidase, CALCIUM ION, CHLORIDE ION, ... 著者 Straeter, N, Knapp, K.M, Zebisch, M, Pippel, J. 登録日 2012-09-12 公開日 2012-11-28 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling. Structure, 20, 2012
4H5B	Crystal Structure of DR_1245 from Deinococcus radiodurans 分子名称: BROMIDE ION, DR_1245 protein, GLYCEROL, ... 著者 Norais, C, Servant, P, Bouthier-de-la-Tour, C, Coureux, P.D, Ithurbide, S, Vannier, F, Guerin, P, Dulberger, C.L, Satyshur, K.A, Keck, J.L, Armengaud, J, Cox, M.M, Sommer, S. 登録日 2012-09-18 公開日 2013-01-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Deinococcus radiodurans DR1245 Protein, a DdrB Partner Homologous to YbjN Proteins and Reminiscent of Type III Secretion System Chaperones. Plos One, 8, 2013
4H2F	Human ecto-5'-nucleotidase (CD73): crystal form I (open) in complex with adenosine 分子名称: 5'-nucleotidase, ADENOSINE, CALCIUM ION, ... 著者 Straeter, N, Knapp, K.M, Zebisch, M, Pippel, J. 登録日 2012-09-12 公開日 2012-11-28 最終更新日 2014-10-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling. Structure, 20, 2012
4DTO	RB69 DNA Polymerase Ternary Complex with dCTP Opposite an Abasic Site and ddA/dT as the Penultimate Base-pair 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... 著者 Xia, S, Wang, J, Konigsberg, W.H. 登録日 2012-02-21 公開日 2012-06-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA. Biochemistry, 51, 2012
4JZL	Crystal structure of BAP31 vDED at alkaline pH 分子名称: B-cell receptor-associated protein 31, GLYCEROL 著者 Quistgaard, E.M, Low, C, Moberg, P, Guettou, F, Maddi, K, Nordlund, P. 登録日 2013-04-03 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP29 and BAP31. Plos One, 8, 2013
4K1E	Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Kallikrein-4, LITHIUM ION, ... 著者 Ilyichova, O.V, Swedberg, J.E, de Veer, S.J, Sit, K.C, Harris, J.M, Buckle, A.M. 登録日 2013-04-04 公開日 2014-04-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics Sci Rep, 6, 2016
4DV2	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, C912A 分子名称: 16S rRNA, MAGNESIUM ION, ZINC ION, ... 著者 Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. 登録日 2012-02-22 公開日 2013-02-27 実験手法 X-RAY DIFFRACTION (3.646 Å) 主引用文献 A structural basis for streptomycin resistance To be Published
4JZP	Crystal structure of BAP31 vDED at acidic pH 分子名称: B-cell receptor-associated protein 31, SULFATE ION, TETRAETHYLENE GLYCOL 著者 Quistgaard, E.M, Low, C, Moberg, P, Guettou, F, Maddi, K, Nordlund, P. 登録日 2013-04-03 公開日 2013-09-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP29 and BAP31. Plos One, 8, 2013
4DTR	RB69 DNA Polymerase Ternary Complex with dATP Opposite an Abasic Site and ddC/dG as the Penultimate Base-pair 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... 著者 Xia, S, Wang, J, Konigsberg, W.H. 登録日 2012-02-21 公開日 2012-06-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA. Biochemistry, 51, 2012
4CB9	Structure of full-length CTNNBL1 in P43212 space group 分子名称: BETA-CATENIN-LIKE PROTEIN 1 著者 Ganesh, K, vanMaldegem, F, Telerman, S.B, Simpson, P, Johnson, C.M, Williams, R.L, Neuberger, M.S, Rada, C. 登録日 2013-10-10 公開日 2013-12-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural and Mutational Analysis Reveals that Ctnnbl1 Binds Nlss in a Manner Distinct from that of its Closest Armadillo-Relative, Karyopherin Alpha FEBS Lett., 588, 2014
4BQG	structure of HSP90 with an inhibitor bound 分子名称: 5-(3,4-dichloro-phenoxy)-benzene-1,3-diol, HSP90AA1 PROTEIN 著者 Casale, E, Brasca, M.G, Mantegani, S, Amboldi, N, Bindi, S, Caronni, D, Ceccarelli, W, Colombo, N, DePonti, A, Donati, D, Ermoli, A, Fachin, G, Felder, E.R, Ferguson, R.D, Fiorelli, C, Guanci, M, Isacchi, A, Pesenti, E, Polucci, P, Riceputi, L, Sola, F, Visco, C, Zuccotto, F, Fogliatto, G. 登録日 2013-05-30 公開日 2013-10-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of Nms-E973 as Novel, Selective and Potent Inhibitor of Heat Shock Protein 90 (Hsp90). Bioorg.Med.Chem., 21, 2013
4CHW	The electron crystallography structure of the cAMP-free potassium channel MloK1 分子名称: CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION 著者 Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H. 登録日 2013-12-04 公開日 2014-01-15 最終更新日 2024-05-08 実験手法 ELECTRON CRYSTALLOGRAPHY (7 Å) 主引用文献 Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1. Nat Commun, 5, 2014
4KGA	Crystal structure of kallikrein-related peptidase 4 分子名称: 1,2-ETHANEDIOL, Kallikrein-4, NICKEL (II) ION 著者 Ilyichova, O.V, Swedberg, J.E, de Veer, S.J, Sit, K.C, Harris, J.M, Buckle, A.M. 登録日 2013-04-29 公開日 2014-04-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics Sci Rep, 6, 2016
4CSS	Crystal structure of FimH in complex with a sulfonamide biphenyl alpha D-mannoside 分子名称: 4'-(alpha-D-Mannopyranosyloxy)-biphenyl-4-methyl sulfonamide, GLYCEROL, PROTEIN FIMH 著者 Kleeb, S, Pang, L, Mayer, K, Sigl, A, Eris, D, Preston, R.C, Zihlmann, P, Abgottspon, D, Hutter, A, Scharenberg, M, Jian, X, Navarra, G, Rabbani, S, Smiesko, M, Luedin, N, Jakob, R.P, Schwardt, O, Maier, T, Sharpe, T, Ernst, B. 登録日 2014-03-10 公開日 2015-02-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.069 Å) 主引用文献 Fimh Antagonists: Bioisosteres to Improve the in Vitro and in Vivo Pk/Pd Profile. J.Med.Chem., 58, 2015
4CPQ	Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol 分子名称: CHLORIDE ION, PROTEASE, methyl [(2S)-1-(2-{(4R)-4-hydroxy-5-{[(2S)-3-methyl-1-oxo-1-(prop-2-en-1-ylamino)butan-2-yl]amino}-5-oxo-4-[4-(prop-2-en-1-yl)benzyl]pentyl}-2-[4-(pyridin-4-yl)benzyl]hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl]carbamate 著者 DeRosa, M, Unge, J, Motwani, H.V, Rosenquist, A, Vrang, L, Wallberg, H, Larhed, M. 登録日 2014-02-08 公開日 2014-12-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Synthesis of P1'-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol. J.Med.Chem., 57, 2014
4H1V	GMP-PNP bound dynamin-1-like protein GTPase-GED fusion 分子名称: Dynamin-1-like protein, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Wenger, J, Klinglmayr, E, Eibl, C, Hessenberger, M, Goettig, P. 登録日 2012-09-11 公開日 2013-08-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Functional Mapping of Human Dynamin-1-Like GTPase Domain Based on X-ray Structure Analyses. Plos One, 8, 2013
4CPT	Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol 分子名称: CHLORIDE ION, PROTEASE, methyl [(2S)-1-(2-{3-[(3R,6S,10Z)-3-hydroxy-4,7-dioxo-6-(propan-2-yl)-5,8-diazabicyclo[11.2.2]heptadeca-1(15),10,13,16-tetraen-3-yl]propyl}-2-[4-(pyridin-3-yl)benzyl]hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl]carbamate 著者 DeRosa, M, Unge, J, Motwani, H.V, Rosenquist, A, Vrang, L, Wallberg, H, Larhed, M. 登録日 2014-02-08 公開日 2014-12-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Synthesis of P1'-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol. J.Med.Chem., 57, 2014
4CSI	Crystal structure of the thermostable Cellobiohydrolase Cel7A from the fungus Humicola grisea var. thermoidea. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CELLULASE, DI(HYDROXYETHYL)ETHER 著者 Haddad-Momeni, M, Goedegebuur, F, Hansson, H, Karkehabadi, S, Askarieh, G, Mitchinson, C, Larenas, E, Stahlberg, J, Sandgren, M. 登録日 2014-03-07 公開日 2014-09-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Expression, Crystal Structure and Cellulase Activity of the Thermostable Cellobiohydrolase Cel7A from the Fungus Humicola Grisea Var. Thermoidea. Acta Crystallogr.,Sect.D, 70, 2014
4H2G	Human ecto-5'-nucleotidase (CD73): crystal form II (open) in complex with adenosine 分子名称: 5'-nucleotidase, ADENOSINE, CALCIUM ION, ... 著者 Straeter, N, Knapp, K.M, Zebisch, M, Pippel, J. 登録日 2012-09-12 公開日 2012-11-28 最終更新日 2012-12-26 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling. Structure, 20, 2012
4C9S	BACTERIAL CHALCONE ISOMERASE IN open CONFORMATION FROM EUBACTERIUM RAMULUS AT 1.8 A RESOLUTION 分子名称: CHALCONE ISOMERASE, CHLORIDE ION, GLYCEROL, ... 著者 Thomsen, M, Palm, G.J, Hinrichs, W. 登録日 2013-10-03 公開日 2014-10-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure and Catalytic Mechanism of the Evolutionarily Unique Bacterial Chalcone Isomerase Acta Crystallogr.,Sect.D, 71, 2015

<391392393394395396397398399400401402403404405406>