4CSS

Crystal structure of FimH in complex with a sulfonamide biphenyl alpha D-mannoside

Summary for 4CSS

Entry DOI	10.2210/pdb4css/pdb
Related	4CST 4CSY
Descriptor	PROTEIN FIMH, 4'-(alpha-D-Mannopyranosyloxy)-biphenyl-4-methyl sulfonamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	sugar binding protein, fimh antagonists, type i pili, uti, upec, adhesin
Biological source	ESCHERICHIA COLI K-12
Cellular location	Fimbrium : P08191
Total number of polymer chains	1
Total formula weight	17958.03
Authors	Kleeb, S.,Pang, L.,Mayer, K.,Sigl, A.,Eris, D.,Preston, R.C.,Zihlmann, P.,Abgottspon, D.,Hutter, A.,Scharenberg, M.,Jian, X.,Navarra, G.,Rabbani, S.,Smiesko, M.,Luedin, N.,Jakob, R.P.,Schwardt, O.,Maier, T.,Sharpe, T.,Ernst, B. (deposition date: 2014-03-10, release date: 2015-02-25, Last modification date: 2023-12-20)
Primary citation	Kleeb, S.,Pang, L.,Mayer, K.,Eris, D.,Sigl, A.,Preston, R.C.,Zihlmann, P.,Sharpe, T.,Jakob, R.P.,Abgottspon, D.,Hutter, A.S.,Scharenberg, M.,Jiang, X.,Navarra, G.,Rabbani, S.,Smiesko, M.,Ludin, N.,Bezencon, J.,Schwardt, O.,Maier, T.,Ernst, B. Fimh Antagonists: Bioisosteres to Improve the in Vitro and in Vivo Pk/Pd Profile. J.Med.Chem., 58:2221-, 2015 Cited by PubMed: 25666045 DOI: 10.1021/JM501524Q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.069 Å)

Structure validation