4CSS
Crystal structure of FimH in complex with a sulfonamide biphenyl alpha D-mannoside
Summary for 4CSS
Entry DOI | 10.2210/pdb4css/pdb |
Related | 4CST 4CSY |
Descriptor | PROTEIN FIMH, 4'-(alpha-D-Mannopyranosyloxy)-biphenyl-4-methyl sulfonamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | sugar binding protein, fimh antagonists, type i pili, uti, upec, adhesin |
Biological source | ESCHERICHIA COLI K-12 |
Cellular location | Fimbrium : P08191 |
Total number of polymer chains | 1 |
Total formula weight | 17958.03 |
Authors | Kleeb, S.,Pang, L.,Mayer, K.,Sigl, A.,Eris, D.,Preston, R.C.,Zihlmann, P.,Abgottspon, D.,Hutter, A.,Scharenberg, M.,Jian, X.,Navarra, G.,Rabbani, S.,Smiesko, M.,Luedin, N.,Jakob, R.P.,Schwardt, O.,Maier, T.,Sharpe, T.,Ernst, B. (deposition date: 2014-03-10, release date: 2015-02-25, Last modification date: 2023-12-20) |
Primary citation | Kleeb, S.,Pang, L.,Mayer, K.,Eris, D.,Sigl, A.,Preston, R.C.,Zihlmann, P.,Sharpe, T.,Jakob, R.P.,Abgottspon, D.,Hutter, A.S.,Scharenberg, M.,Jiang, X.,Navarra, G.,Rabbani, S.,Smiesko, M.,Ludin, N.,Bezencon, J.,Schwardt, O.,Maier, T.,Ernst, B. Fimh Antagonists: Bioisosteres to Improve the in Vitro and in Vivo Pk/Pd Profile. J.Med.Chem., 58:2221-, 2015 Cited by PubMed: 25666045DOI: 10.1021/JM501524Q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.069 Å) |
Structure validation
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