4CSY

E-selectin lectin, EGF-like and two SCR domains complexed with Sialyl Lewis X

Summary for 4CSY

Entry DOI	10.2210/pdb4csy/pdb
Related	4CSS 4CST
Descriptor	E-SELECTIN, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	cell-adhesion, human lectin, c-type lectin, inflammation, leukocyte, sialyl lewis x, slex, protein conformation, ligand-induced conformational change, catch- bond, cell adhesion
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane ; Single-pass type I membrane protein: P16581
Total number of polymer chains	2
Total formula weight	67458.13
Authors	Preston, R.C.,Jakob, R.P.,Binder, F.P.C.,Sager, C.P.,Ernst, B.,Maier, T. (deposition date: 2014-03-11, release date: 2014-09-24, Last modification date: 2023-12-20)
Primary citation	Preston, R.C.,Jakob, R.P.,Binder, F.P.,Sager, C.P.,Ernst, B.,Maier, T. E-Selectin Ligand Complexes Adopt an Extended High-Affinity Conformation. J.Mol.Cell.Biol., 8:62-, 2016 Cited by PubMed: 26117840 DOI: 10.1093/JMCB/MJV046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation