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8GIP
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BU of 8gip by Molmil
Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.040mM Mn2+
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, MAGNESIUM ION, ...
著者Wu, S, Sohn, J.
登録日2023-03-14
公開日2024-05-22
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.
Nat Commun, 15, 2024
8J6L
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BU of 8j6l by Molmil
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X.
登録日2023-04-26
公開日2024-04-03
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2.
Cell Rep, 42, 2023
2NR0
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BU of 2nr0 by Molmil
Crystal structure of pseudoudirinde synthase TruA in complex with leucyl tRNA
分子名称: leucyl tRNA, tRNA pseudouridine synthase A
著者Hur, S, Stroud, R.M.
登録日2006-11-01
公開日2007-05-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献How U38, 39, and 40 of Many tRNAs Become the Targets for Pseudouridylation by TruA.
Mol.Cell, 26, 2007
6GDQ
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BU of 6gdq by Molmil
Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2
分子名称: 4-[5-chloranyl-2-(propan-2-ylamino)pyridin-4-yl]-~{N}-[(1~{S})-1-(3-chlorophenyl)-2-oxidanyl-ethyl]-1~{H}-pyrrole-2-carboxamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ...
著者O'Reilly, M.
登録日2018-04-24
公開日2018-05-30
最終更新日2018-06-27
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
8J74
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BU of 8j74 by Molmil
Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, dimeric state
分子名称: (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium), CHOLESTEROL HEMISUCCINATE, HEXADECANE, ...
著者Gao, Y, Qiu, Y, Zhao, Y.
登録日2023-04-27
公開日2024-04-03
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Transport mechanism of presynaptic high-affinity choline uptake by CHT1.
Nat.Struct.Mol.Biol., 31, 2024
2OJG
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BU of 2ojg by Molmil
Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
分子名称: Mitogen-activated protein kinase 1, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION
著者Xie, X, Jacobs, M.D.
登録日2007-01-12
公開日2007-02-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors.
J.Med.Chem., 50, 2007
8J29
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BU of 8j29 by Molmil
Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus
分子名称: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR
著者Ma, Q, Liu, C.
登録日2023-04-14
公開日2024-04-17
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus
To Be Published
8J2A
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BU of 8j2a by Molmil
Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+
分子名称: GLYCEROL, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Ma, Q, Liu, C.
登録日2023-04-14
公開日2024-04-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus
To Be Published
8J2D
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BU of 8j2d by Molmil
Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+
分子名称: GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR
著者Ma, Q, Liu, C.
登録日2023-04-14
公開日2024-04-17
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus
To Be Published
8J2C
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BU of 8j2c by Molmil
Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R
分子名称: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR
著者Ma, Q, Liu, C.
登録日2023-04-14
公開日2024-04-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus
To Be Published
8J2E
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BU of 8j2e by Molmil
Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+ and malonate
分子名称: MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR
著者Ma, Q, Liu, C.
登録日2023-04-14
公開日2024-04-17
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus
To Be Published
8EYQ
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BU of 8eyq by Molmil
30S_delta_ksgA_h44_inactive_conformation
分子名称: 16S_rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
著者Ortega, J, Sun, J.
登録日2022-10-28
公開日2023-09-06
最終更新日2023-11-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion.
Nat.Struct.Mol.Biol., 30, 2023
8J2B
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BU of 8j2b by Molmil
Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+ and malonate
分子名称: MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR
著者Ma, Q, Liu, C.
登録日2023-04-14
公開日2024-04-17
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus
To Be Published
6G9D
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BU of 6g9d by Molmil
Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2
分子名称: Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]ethanamide
著者O'Reilly, M.
登録日2018-04-10
公開日2018-05-30
最終更新日2018-06-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G9M
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BU of 6g9m by Molmil
Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2
分子名称: 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-(2-phenylpropan-2-yl)ethanamide, Mitogen-activated protein kinase 1, SULFATE ION
著者O'Reilly, M.
登録日2018-04-11
公開日2018-05-30
最終更新日2018-06-27
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
2NX7
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BU of 2nx7 by Molmil
Structure of NOWA cysteine rich domain 8
分子名称: Nematocyst outer wall antigen
著者Meier, S, Jensen, P.R, Adamczyk, P, Bachinger, H.P, Holstein, T.W, Engel, J, Ozbek, S, Grzesiek, S.
登録日2006-11-17
公開日2007-10-02
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.
J.Mol.Biol., 368, 2007
6GAK
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BU of 6gak by Molmil
Crystal structure of the T1L reovirus sigma1 coiled coil tail (chloride)
分子名称: CHLORIDE ION, Outer capsid protein sigma-1
著者Dietrich, M.H, Stehle, T.
登録日2018-04-11
公開日2018-04-25
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Structural and Functional Features of the Reovirus sigma 1 Tail.
J. Virol., 92, 2018
6FUF
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BU of 6fuf by Molmil
Crystal structure of the rhodopsin-mini-Go complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(o) subunit alpha, RETINAL, ...
著者Tsai, C.-J, Weinert, T, Muehle, J, Pamula, F, Nehme, R, Flock, T, Nogly, P, Edwards, P.C, Carpenter, B, Gruhl, T, Ma, P, Deupi, X, Standfuss, J, Tate, C.G, Schertler, G.F.X.
登録日2018-02-27
公開日2018-10-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.117 Å)
主引用文献Crystal structure of rhodopsin in complex with a mini-Gosheds light on the principles of G protein selectivity.
Sci Adv, 4, 2018
6GDM
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BU of 6gdm by Molmil
Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2
分子名称: (3~{R})-1-[2-oxidanylidene-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-~{N}-(3-pyridin-4-yl-1~{H}-indazol-5-yl)pyrrolidine-3-carboxamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ...
著者O'Reilly, M.
登録日2018-04-24
公開日2018-05-30
最終更新日2018-06-27
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
8EYT
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BU of 8eyt by Molmil
30S_delta_ksgA+KsgA complex
分子名称: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
著者Sun, J, Kinman, L.F, Jahagirdar, D, Ortega, J, Davis, J.H.
登録日2022-10-28
公開日2023-09-06
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion.
Nat.Struct.Mol.Biol., 30, 2023
8FI2
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BU of 8fi2 by Molmil
Structure of Lettuce C20T bound to DFHBI-1T
分子名称: (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-3-(2,2,2-trifluoroethyl)-3,5-dihydro-4H-imidazol-4-one, Lettuce DNA aptamer, MAGNESIUM ION, ...
著者Passalacqua, L.F.M, Ferre-D'Amare, A.R.
登録日2022-12-15
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Intricate 3D architecture of a DNA mimic of GFP.
Nature, 618, 2023
8F8Q
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BU of 8f8q by Molmil
Cryo-EM structure of the CapZ-capped barbed end of F-actin
分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
著者Carman, P.J, Barrie, K.R, Dominguez, R.
登録日2022-11-22
公開日2023-06-07
最終更新日2023-07-05
実験手法ELECTRON MICROSCOPY (2.79 Å)
主引用文献Structures of the free and capped ends of the actin filament.
Science, 380, 2023
8FI1
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BU of 8fi1 by Molmil
Structure of Lettuce C20G bound to DFHO
分子名称: (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, Lettuce DNA aptamer, MAGNESIUM ION, ...
著者Passalacqua, L.F.M, Ferre-D'Amare, A.R.
登録日2022-12-15
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Intricate 3D architecture of a DNA mimic of GFP.
Nature, 618, 2023
8FI0
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BU of 8fi0 by Molmil
Structure of Lettuce aptamer bound to DFAME
分子名称: Lettuce DNA aptamer, MAGNESIUM ION, POTASSIUM ION, ...
著者Passalacqua, L.F.M, Ferre-D'Amare, A.R.
登録日2022-12-15
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Intricate 3D architecture of a DNA mimic of GFP.
Nature, 618, 2023
8FI7
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BU of 8fi7 by Molmil
Structure of Lettuce C20T bound to DFHO
分子名称: (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, Lettuce DNA aptamer, MAGNESIUM ION, ...
著者Passalacqua, L.F.M, Ferre-D'Amare, A.R.
登録日2022-12-15
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Intricate 3D architecture of a DNA mimic of GFP.
Nature, 618, 2023

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件を2024-08-21に公開中

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