2YCW
 
 | | TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CARAZOLOL | | 分子名称: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, BETA-1 ADRENERGIC RECEPTOR, HEGA-10, ... | | 著者 | Moukhametzianov, R, Warne, T, Edwards, P.C, Serrano-Vega, M.J, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X. | | 登録日 | 2011-03-17 | | 公開日 | 2011-06-01 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
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9D4V
 | | Structure of PAK1 in complex with compound 7 | | 分子名称: | N~2~-{[(1s,4s)-4-aminocyclohexyl]methyl}-N~4~-(5-cyclopropyl-1,3-thiazol-2-yl)pyrimidine-2,4-diamine, Serine/threonine-protein kinase PAK 1 | | 著者 | Dementiev, A, Boone, C.D, Suto, R.K, Olland, A.M. | | 登録日 | 2024-08-13 | | 公開日 | 2025-04-02 | | 最終更新日 | 2025-07-16 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Identification of a p21-activated kinase 1 (PAK1) inhibitor with 10-fold selectivity against PAK2.
Bioorg.Med.Chem.Lett., 127, 2025
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3TNN
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3TKU
 | | MRCK beta in complex with fasudil | | 分子名称: | 1,2-ETHANEDIOL, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, Serine/threonine-protein kinase MRCK beta | | 著者 | Heikkila, T.J, Turnbull, A, Wheatley, E, Schroder, E, Crighton, D, Olson, M.F. | | 登録日 | 2011-08-29 | | 公開日 | 2011-10-05 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Co-crystal structures of inhibitors with MRCK, a key regulator of tumor cell invasion
Plos One, 6, 2011
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6NWL
 | | Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with hydrocortisone and PGC1a coregulator fragment | | 分子名称: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... | | 著者 | Liu, X, Ortlund, E.A. | | 登録日 | 2019-02-06 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.595 Å) | | 主引用文献 | First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-ActivatedgammaCoactivator 1-alphaComplex with Endogenous and Synthetic Glucocorticoids.
Mol.Pharmacol., 96, 2019
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1U8Q
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELEKWAS | | 分子名称: | ANTIBODY 2F5 (HEAVY CHAIN), ANTIBODY 2F5 (LIGHT CHAIN), GP41 PEPTIDE | | 著者 | Bryson, S, Julien, J.-P, Hynes, R.C, Pai, E.F. | | 登録日 | 2004-08-06 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications
J.Virol., 83, 2009
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1U93
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide Analog EQDKW-[Dap]-S (cyclic) | | 分子名称: | ANTIBODY 2F5 (HEAVY CHAIN), ANTIBODY 2F5 (LIGHT CHAIN), GP41 PEPTIDE ANALOG | | 著者 | Bryson, S, Julien, J.-P, Hynes, R.C, Pai, E.F. | | 登録日 | 2004-08-09 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications
J.Virol., 83, 2009
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1U8O
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKHAS | | 分子名称: | ANTIBODY 2F5 (HEAVY CHAIN), ANTIBODY 2F5 (LIGHT CHAIN), GP41 PEPTIDE | | 著者 | Bryson, S, Julien, J.-P, Hynes, R.C, Pai, E.F. | | 登録日 | 2004-08-06 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | | 主引用文献 | Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications
J.Virol., 83, 2009
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3U8F
 | | Crystal structure of the complex of type I Ribosome inactivating protein in complex with Mycolic acid at 1.8 A resolution | | 分子名称: | (2R,3R)-2-hexyl-3-hydroxytridecanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | 著者 | Yamini, S, Pandey, S, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | | 登録日 | 2011-10-17 | | 公開日 | 2011-11-16 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of the complex of type I Ribosome inactivating protein in complex with Mycolic acid at 1.8 A resolution
To be Published
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1UAK
 | | Crystal structure of tRNA(m1G37)methyltransferase: Insight into tRNA recognition | | 分子名称: | S-ADENOSYLMETHIONINE, tRNA (Guanine-N(1)-)-methyltransferase | | 著者 | Ahn, H.J, Kim, H.-W, Yoon, H.-J, Lee, B.I, Suh, S.W, Yang, J.K. | | 登録日 | 2003-03-11 | | 公開日 | 2003-06-17 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal structure of tRNA(m(1)G37)methyltransferase: insights into tRNA recognition
EMBO J., 22, 2003
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8QYX
 | | Human 60S ribosomal subunit | | 分子名称: | 1,4-DIAMINOBUTANE, 28S rRNA, 5.8S rRNA, ... | | 著者 | Wiechert, F, Schacherl, M, Sprink, T. | | 登録日 | 2023-10-26 | | 公開日 | 2024-12-11 | | 最終更新日 | 2025-01-22 | | 実験手法 | ELECTRON MICROSCOPY (1.78 Å) | | 主引用文献 | Visualizing the modification landscape of the human 60S ribosomal subunit at close to atomic resolution.
Nucleic Acids Res., 53, 2025
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4YVF
 | | Structure of S-adenosyl-L-homocysteine hydrolase | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{[5-chloro-2-(4-chlorophenoxy)phenyl](2-{[2-(methylamino)ethyl]amino}-2-oxoethyl)amino}-N-(1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide, Adenosylhomocysteinase | | 著者 | Akiko, K. | | 登録日 | 2015-03-20 | | 公開日 | 2015-11-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Discovery and structural analyses of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs.
Bioorg.Med.Chem., 23, 2015
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8QG7
 | | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a di-adenosine derivative | | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]prop-2-ynyl-pent-4-ynyl-amino]methyl]oxolane-3,4-diol, CITRIC ACID, NAD kinase 1 | | 著者 | Gelin, M, Labesse, G, Lionne, C. | | 登録日 | 2023-09-05 | | 公開日 | 2025-03-19 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a di-adenosine derivative
To Be Published
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8QGK
 | | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a di-adenosine derivative | | 分子名称: | CITRIC ACID, NAD kinase 1, ~{N}-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]prop-2-ynyl]amino]propyl]ethanamide | | 著者 | Gelin, M, Labesse, G, Lionne, C. | | 登録日 | 2023-09-05 | | 公開日 | 2025-03-19 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a di-adenosine derivative
To Be Published
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8QG9
 | | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a di-adenosine derivative | | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]prop-2-ynyl-propan-2-yl-amino]methyl]oxolane-3,4-diol, CITRIC ACID, NAD kinase 1 | | 著者 | Gelin, M, Labesse, G, Lionne, C. | | 登録日 | 2023-09-05 | | 公開日 | 2025-03-19 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a di-adenosine derivative
To Be Published
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6NB2
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1U8I
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKWAN | | 分子名称: | ANTIBODY 2F5 (HEAVY CHAIN), ANTIBODY 2F5 (LIGHT CHAIN), GP41 PEPTIDE | | 著者 | Bryson, S, Julien, J.-P, Hynes, R.C, Pai, E.F. | | 登録日 | 2004-08-06 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications
J.Virol., 83, 2009
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3TW2
 | | High resolution structure of human histidine triad nucleotide-binding protein 1 (hHINT1)/AMP complex in a monoclinic space group | | 分子名称: | ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1 | | 著者 | Dolot, R.M, Wlodarczyk, A, Ozga, M, Krakowiak, A, Nawrot, B. | | 登録日 | 2011-09-21 | | 公開日 | 2011-11-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 A resolution.
Acta Crystallogr.,Sect.F, 68, 2012
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1UAL
 | | Crystal structure of tRNA(m1G37)methyltransferase: Insight into tRNA recognition | | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, tRNA (Guanine-N(1)-)-methyltransferase | | 著者 | Ahn, H.J, Kim, H.-W, Yoon, H.-J, Lee, B.I, Suh, S.W, Yang, J.K. | | 登録日 | 2003-03-11 | | 公開日 | 2003-06-17 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of tRNA(m(1)G37)methyltransferase: insights into tRNA recognition
EMBO J., 22, 2003
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2YNU
 | | Apo GIM-1 with 2Mol. Crystal structures of Pseudomonas aeruginosa GIM-1: active site plasticity in metallo-beta-lactamases | | 分子名称: | GIM-1 PROTEIN | | 著者 | Borra, P.S, Samuelsen, O, Spencer, J, Lorentzen, M.S, Leiros, H.-K.S. | | 登録日 | 2012-10-18 | | 公開日 | 2013-07-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Crystal Structures of Pseudomonas Aeruginosa Gim-1: Active-Site Plasticity in Metallo-Beta-Lactamases.
Antimicrob.Agents Chemother., 57, 2013
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6E0Q
 | | The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid | | 分子名称: | 1,2-ETHANEDIOL, 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid, MANGANESE (II) ION, ... | | 著者 | Dick, B.L, Morrison, C.N, Cohen, S.M. | | 登録日 | 2018-07-06 | | 公開日 | 2018-11-07 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease.
J. Med. Chem., 61, 2018
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1U8N
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKFAS | | 分子名称: | ANTIBODY 2F5 (HEAVY CHAIN), ANTIBODY 2F5 (LIGHT CHAIN), GP41 PEPTIDE | | 著者 | Bryson, S, Julien, J.-P, Hynes, R.C, Pai, E.F. | | 登録日 | 2004-08-06 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications
J.Virol., 83, 2009
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1U95
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDHWAS | | 分子名称: | ANTIBODY 2F5 (HEAVY CHAIN), ANTIBODY 2F5 (LIGHT CHAIN), GP41 PEPTIDE | | 著者 | Bryson, S, Julien, J.-P, Hynes, R.C, Pai, E.F. | | 登録日 | 2004-08-09 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications
J.Virol., 83, 2009
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1U8P
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ECDKWCS | | 分子名称: | ANTIBODY 2F5 (HEAVY CHAIN), ANTIBODY 2F5 (LIGHT CHAIN), GP41 PEPTIDE | | 著者 | Bryson, S, Julien, J.-P, Hynes, R.C, Pai, E.F. | | 登録日 | 2004-08-06 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | | 主引用文献 | Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications
J.Virol., 83, 2009
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1U92
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide Analog E-[Dap]-DKWQS (cyclic) | | 分子名称: | ANTIBODY 2F5 (HEAVY CHAIN), ANTIBODY 2F5 (LIGHT CHAIN), GP41 PEPTIDE ANALOG | | 著者 | Bryson, S, Julien, J.-P, Hynes, R.C, Pai, E.F. | | 登録日 | 2004-08-09 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications
J.Virol., 83, 2009
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