PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

---

5J2N	HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and dTMP at the N-(pre-translocation) site 分子名称: DNA (27-MER), DNA 5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3', MAGNESIUM ION, ... 著者 Salie, Z.L, Kirby, K.A, Sarafianos, S.G. 登録日 2016-03-29 公開日 2016-08-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.896 Å) 主引用文献 Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA). Proc.Natl.Acad.Sci.USA, 113, 2016
6T3B	Crystal structure of PI3Kgamma with a dihydropurinone inhibitor (compound 4) 分子名称: 2-[(4-methoxy-2-methyl-phenyl)amino]-7-methyl-9-(4-oxidanylcyclohexyl)purin-8-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 著者 Petersen, J, Oster, L, Schimpl, M, Goldberg, F.W, Finlay, M.R.V, Ting, A.K.T, Beattie, D, Lamont, G.M, Fallan, C, Wrigley, G.L, Howard, M.R, Williamson, B, Davies, B.R, Cadogan, E.B, Ramos-Montoya, A, Dean, E. 登録日 2019-10-10 公開日 2020-01-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor. J.Med.Chem., 63, 2020
7JPS	ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*T)-3'), ... 著者 Jaremko, M.J, Joshua-Tor, L. 登録日 2020-08-09 公開日 2020-09-09 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
6T2W	Crystal structure of the CSF1R kinase domain with a dihydropurinone inhibitor (compound 4) 分子名称: 2-[(4-methoxy-2-methyl-phenyl)amino]-7-methyl-9-(4-oxidanylcyclohexyl)purin-8-one, Macrophage colony-stimulating factor 1 receptor, SULFATE ION 著者 Schimpl, M, Goldberg, F.W, Finlay, M.R.V, Ting, A.K.T, Beattie, D, Lamont, G.M, Fallan, C, Wrigley, G.L, Howard, M.R, Williamson, B, Davies, B.R, Cadogan, E.B, Ramos-Montoya, A, Dean, E. 登録日 2019-10-09 公開日 2020-01-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor. J.Med.Chem., 63, 2020
7O0H	Structure of the foamy viral protease-reverse transcriptase dRH in complex with ds DNA. 分子名称: DNA (5'-D(*AP*AP*CP*AP*GP*AP*GP*TP*GP*CP*GP*AP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*TP*CP*GP*CP*AP*CP*TP*CP*TP*G)-3'), Pr125Pol 著者 Nowak, E, Nowacka, M, Nowotny, M. 登録日 2021-03-26 公開日 2021-06-30 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase. J.Virol., 95, 2021
7R78	cryo-EM structure of DNMT5 quaternary complex with hemimethylated DNA, AMP-PNP and SAH 分子名称: DNA (5'-D(*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), DNA (5'-D(P*CP*AP*GP*(5CM)P*GP*CP*AP*T)-3'), DNA repair protein Rad8, ... 著者 Wang, J, Patel, D.J. 登録日 2021-06-24 公開日 2022-02-23 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
8IT0	Cryo-EM structure of Crt-SPARTA-gRNA-tDNA dimer (conformation-2) 分子名称: DNA (45-mer), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*U)-3'), ... 著者 Gao, X, Shang, K, Zhu, K, Wang, L, Mu, Z, Fu, X, Yu, X, Qin, B, Zhu, H, Ding, W, Cui, S. 登録日 2023-03-21 公開日 2023-10-18 最終更新日 2024-02-07 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature, 625, 2024
8ISZ	Cryo-EM structure of Crt-SPARTA-gRNA-tDNA monomer 分子名称: DNA (45-mer), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*U)-3'), ... 著者 Gao, X, Shang, K, Zhu, K, Wang, L, Mu, Z, Fu, X, Yu, X, Qin, B, Zhu, H, Ding, W, Cui, S. 登録日 2023-03-21 公開日 2023-10-18 最終更新日 2024-02-07 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature, 625, 2024
8IT1	Cryo-EM structure of Crt-SPARTA-gRNA-tDNA tetramer (NADase active form) 分子名称: DNA (45-mer), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*U)-3'), ... 著者 Gao, X, Shang, K, Zhu, K, Wang, L, Mu, Z, Fu, X, Yu, X, Qin, B, Zhu, H, Ding, W, Cui, S. 登録日 2023-03-21 公開日 2023-11-08 最終更新日 2024-02-07 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature, 625, 2024
7O0G	Structure of the foamy viral protease-reverse transcriptase in complex with RNA/DNA hybrid. 分子名称: DNA (5'-D(*CP*CP*TP*CP*TP*CP*CP*TP*GP*GP*AP*CP*AP*AP*G)-3'), Pr125Pol, RNA (5'-R(*UP*UP*CP*UP*UP*GP*UP*CP*CP*AP*GP*GP*AP*GP*AP*GP*G)-3') 著者 Nowak, E, Nowacka, M, Nowotny, M. 登録日 2021-03-26 公開日 2021-06-30 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase. J.Virol., 95, 2021
7R77	Cryo-EM structure of DNMT5 binary complex with hemimethylated DNA 分子名称: DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), DNA repair protein Rad8, ZINC ION 著者 Wang, J, Patel, D.J. 登録日 2021-06-24 公開日 2022-02-23 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
5I50	Structure of OmoMYC bound to double-stranded DNA 分子名称: DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3'), Myc proto-oncogene protein 著者 Koelmel, W, Jung, L.A, Kuper, J, Eilers, M, Kisker, C. 登録日 2016-02-13 公開日 2016-10-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.701 Å) 主引用文献 OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene, 36, 2017
8K9G	Cryo-EM structure of Crt-SPARTA-gRNA-tDNA dimer (conformation-1) 分子名称: DNA (45-mer), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*U)-3'), ... 著者 Gao, X, Shang, K, Zhu, K, Wang, L, Mu, Z, Fu, X, Yu, X, Qin, B, Zhu, H, Ding, W, Cui, S. 登録日 2023-08-01 公開日 2023-10-18 最終更新日 2024-02-07 実験手法 ELECTRON MICROSCOPY (3.49 Å) 主引用文献 Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature, 625, 2024
2E1C	Structure of Putative HTH-type transcriptional regulator PH1519/DNA Complex 分子名称: DNA (5'-D(*DAP*DGP*DTP*DGP*DAP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DTP*DCP*DAP*DCP*DA)-3'), DNA (5'-D(*DTP*DGP*DTP*DGP*DAP*DAP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DCP*DAP*DCP*DT)-3'), Putative HTH-type transcriptional regulator PH1519 著者 Koike, H, Suzuki, M. 登録日 2006-10-24 公開日 2007-12-04 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Feast/Famine Regulation by Transcription Factor FL11 for the Survival of the Hyperthermophilic Archaeon Pyrococcus OT3. Structure, 15, 2007
4DKY	Crystal structure Analysis of N terminal region containing the dimerization domain and DNA binding domain of HU protein(Histone like protein-DNA binding) from Mycobacterium tuberculosis [H37Ra] 分子名称: DNA-binding protein HU homolog, MANGANESE (II) ION 著者 Bhowmick, T, Ramagopal, U.A, Ghosh, S, Nagaraja, V, Ramakumar, S. 登録日 2012-02-05 公開日 2013-02-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.478 Å) 主引用文献 Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors Nat Commun, 5, 2014
8FDP	The native structure of a dodecamer: 5'-CGCAAATTTGCG-3 分子名称: DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3') 著者 Ogbonna, E, Wilson, W.D. 登録日 2022-12-04 公開日 2023-02-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences. Acs Bio Med Chem Au, 3, 2023
8U5Y	human RADX trimer bound to ssDNA 分子名称: DNA (25-MER), RPA-related protein RADX 著者 Balakrishnan, S, Chazin, W.J. 登録日 2023-09-13 公開日 2023-10-11 最終更新日 2023-10-18 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structure of RADX and mechanism for regulation of RAD51 nucleofilaments. Biorxiv, 2023
7RHY	Cre recombinase mutant (D33A/A36V/R192A) in complex with loxA DNA hairpin 分子名称: DNA (49-MER), Recombinase cre 著者 Stachowski, K, Foster, M.P. 登録日 2021-07-19 公開日 2022-01-19 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.91 Å) 主引用文献 Mechanisms of Cre recombinase synaptic complex assembly and activation illuminated by Cryo-EM. Nucleic Acids Res., 50, 2022
3KLF	Crystal structure of wild-type HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA 分子名称: DNA (5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(2DA))-3'), DNA (5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), GLYCEROL, ... 著者 Tu, X, Das, K, Sarafianos, S.G, Arnold, E. 登録日 2009-11-07 公開日 2010-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structural basis of HIV-1 resistance to AZT by excision. Nat.Struct.Mol.Biol., 17, 2010
3KLE	Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA 分子名称: DNA (25-MER), DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(2DA))-3'), GLYCEROL, ... 著者 Tu, X, Das, K, Sarafianos, S.G, Arnold, E. 登録日 2009-11-07 公開日 2010-09-22 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural basis of HIV-1 resistance to AZT by excision. Nat.Struct.Mol.Biol., 17, 2010
6OUN	Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP 分子名称: DNA primer 20-mer, DNA template 27-mer, Lamivudine Triphosphate, ... 著者 Bertoletti, N, Anderson, K.S. 登録日 2019-05-04 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.656 Å) 主引用文献 Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine. Protein Sci., 28, 2019
6OTZ	Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (+)FTC-TP 分子名称: DNA Primer 20-mer, DNA template 27-mer, GLYCEROL, ... 著者 Bertoletti, N, Anderson, K.S. 登録日 2019-05-03 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.857 Å) 主引用文献 Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine. Protein Sci., 28, 2019
4Y00	Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA 分子名称: DNA (5'-D(P*TP*TP*GP*AP*GP*CP*GP*T)-3'), TAR DNA-binding protein 43 著者 Chiang, C.H, Kuo, P.H, Yang, W.Z, Yuan, H.S. 登録日 2015-02-05 公開日 2016-02-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation Sci Rep, 6, 2016
6P1X	Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and L-ddCTP 分子名称: DNA Primer 20-mer, DNA template 27-mer, MAGNESIUM ION, ... 著者 Bertoletti, N, Anderson, K.S. 登録日 2019-05-20 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.553 Å) 主引用文献 Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine. Protein Sci., 28, 2019
4Y0F	Crystal Structure of Human TDP-43 RRM1 Domain in Complex with an Unmodified Single-stranded DNA 分子名称: DNA (5'-D(*GP*TP*TP*GP*AP*GP*CP*GP*TP*T)-3'), TAR DNA-binding protein 43 著者 Chiang, C.H, Kuo, P.H, Doudeva, L.G, Wang, Y.T, Yuan, H.S. 登録日 2015-02-06 公開日 2016-02-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.648 Å) 主引用文献 Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation Sci Rep, 6, 2016

<358359360361362363364365366367368369370371372373>