PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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4AE9	Structure and function of the Human Sperm-Specific Isoform of Protein Kinase A (PKA) Catalytic Subunit C alpha 2 分子名称: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA 著者 Hereng, T.H, Backe, P.H, Kahmann, J, Scheich, C, Bjoras, M, Skalhegg, B.S, Rosendal, K.R. 登録日 2012-01-09 公開日 2012-04-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure and Function of the Human Sperm-Specific Isoform of Protein Kinase a (Pka) Catalytic Subunit Calpha2 J.Struct.Biol., 178, 2012
7SPZ	Nucleotide-free Get3 in two open forms 分子名称: ATPase ASNA1 homolog, ZINC ION 著者 Fry, M.Y, Maggiolo, A.O, Clemons Jr, W.M. 登録日 2021-11-04 公開日 2022-07-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3. Nat.Struct.Mol.Biol., 29, 2022
7T31	X-ray Structure of Clostridiodies difficile PilW 分子名称: Maltose/maltodextrin-binding periplasmic protein,Putative pilin protein chimera 著者 Ronish, L.A, Piepenbrink, K.H. 登録日 2021-12-06 公開日 2022-10-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Recognition of extracellular DNA by type IV pili promotes biofilm formation by Clostridioides difficile. J.Biol.Chem., 298, 2022
6PSJ	Bazedoxifene in Complex with Y537S Estrogen Receptor Alpha Ligand Binding Domain 分子名称: Bazedoxifene, Estrogen receptor 著者 Fanning, S.W, Greene, G.L. 登録日 2019-07-12 公開日 2019-11-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022
6PV4	Structure of CpGH84A 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Glycoside Hydrolase 著者 Pluvinage, B, Boraston, A.B. 登録日 2019-07-19 公開日 2019-09-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and functional analysis of four family 84 glycoside hydrolases from the opportunistic pathogen Clostridium perfringens. Glycobiology, 30, 2019
7TT8	Human LRH-1 LBD bound to agonist 6N-10CA and fragment of Tif2 coactivator 分子名称: 10-[(3aR,6S,6aR)-3-phenyl-3a-(1-phenylethenyl)-6-(sulfamoylamino)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic acid (non-preferred name), Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 著者 Cato, M.L, Ortlund, E.A. 登録日 2022-01-31 公開日 2022-05-11 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. J.Med.Chem., 65, 2022
5N7G	MAGI-1 complexed with a synthetic pRSK1 peptide 分子名称: CALCIUM ION, GLYCEROL, Membrane-associated guanylate kinase, ... 著者 Gogl, G, Nyitray, L. 登録日 2017-02-20 公開日 2017-11-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Dynamic control of RSK complexes by phosphoswitch-based regulation. FEBS J., 285, 2018
6Q1N	Glucocerebrosidase in complex with pharmacological chaperone IMX8 分子名称: (2R,3S,4S,5R)-2-[2-(methylsulfanyl)ethyl]piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Vickers, C, Withers, S.G, Boraston, A.B. 登録日 2019-08-05 公開日 2020-08-19 実験手法 X-RAY DIFFRACTION (2.526 Å) 主引用文献 Pharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher animal models. To Be Published
7C83	Crystal structure of an integral membrane steroid 5-alpha-reductase PbSRD5A 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-oxo-5-alpha-steroid 4-dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Ren, R.B, Han, Y.F, Xiao, Q.J, Deng, D. 登録日 2020-05-28 公開日 2021-01-27 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism. Nat Commun, 12, 2021
6Q6K	Crystal structure of recombinant human beta-glucocerebrosidase in complex with cyclophellitol activity based probe with Cy5 tag (ME569) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-[3,3-dimethyl-2-[(1~{E},3~{E},5~{E})-5-(1,3,3-trimethylindol-2-ylidene)penta-1,3-dienyl]indol-1-ium-1-yl]-~{N}-[[1-[[(1~{S},2~{R},3~{R},4~{S},6~{S})-2,3,4,6-tetrakis(oxidanyl)cyclohexyl]methyl]-1,2,3-triazol-4-yl]methyl]hexanamide, ... 著者 Rowland, R.J, Davies, G.J. 登録日 2018-12-11 公開日 2019-03-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish. J.Am.Chem.Soc., 141, 2019
6XP7	Nucleoside Diphosphate Kinase from Aspergillus fumgiatus Af293 bound to ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase 著者 Nguyen, S, Bruning, J.B. 登録日 2020-07-08 公開日 2020-11-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Nucleoside selectivity of Aspergillus fumigatus nucleoside-diphosphate kinase. Febs J., 288, 2021
5LIW	Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK319 分子名称: 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Fanfrlik, J, Kamlar, M, Vesely, J, Hobza, P, Podjarny, A. 登録日 2016-07-15 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Acs Chem.Biol., 11, 2016
4A1G	The crystal structure of the human Bub1 TPR domain in complex with the KI motif of Knl1 分子名称: MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1, PROTEIN CASC5 著者 Krenn, V, Wehenkel, A, Li, X, Santaguida, S, Musacchio, A. 登録日 2011-09-15 公開日 2012-02-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Analysis Reveals Features of the Spindle Checkpoint Kinase Bub1-Kinetochore Subunit Knl1 Interaction. J.Cell Biol., 196, 2012
7XFG	NMR solution structures of p300 TAZ2 domain in complex with BRD4-NUT F1c domain binding motif #1 分子名称: Histone acetyltransferase p300, NUT family member 1, ZINC ION 著者 Yu, D, Zeng, L, Zhou, M.-M. 登録日 2022-04-01 公開日 2023-04-12 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural Mechanism of BRD4-NUT Fusion Protein in p300-Activated Hyperacetylation To Be Published
6WHJ	Structure of Ribokinase from Giardia lamblia 分子名称: 1,2-ETHANEDIOL, Ribokinase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2020-04-08 公開日 2020-04-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure of Ribokinase from Giardia lamblia to be published
7XEZ	NMR solution structures of p300 TAZ2 domain in complex with BRD4-NUT F1c domain binding motif #2 分子名称: Histone acetyltransferase p300,NUT family member 1, ZINC ION 著者 Yu, D, Zeng, L, Zhou, M.-M. 登録日 2022-03-31 公開日 2023-04-12 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural Mechanism of BRD4-NUT Fusion Protein in p300-Activated Hyperacetylation To Be Published
6XPU	Nucleoside Diphosphate Kinase from Aspergillus fumgiatus Af293 bound to IDP 分子名称: INOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside diphosphate kinase 著者 Nguyen, S, Bruning, J.B. 登録日 2020-07-09 公開日 2020-11-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Nucleoside selectivity of Aspergillus fumigatus nucleoside-diphosphate kinase. Febs J., 288, 2021
6QIX	The crystal structure of Trichuris muris p43 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... 著者 Levy, C.W. 登録日 2019-01-21 公開日 2019-06-12 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function. Nat Commun, 10, 2019
5A9I	Crystal structure of the extracellular domain of PepT2 分子名称: CITRIC ACID, GLYCEROL, SOLUTE CARRIER FAMILY 15 MEMBER 2 著者 Beale, J.H, Newstead, S. 登録日 2015-07-21 公開日 2015-09-09 最終更新日 2019-10-09 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Crystal Structures of the Extracellular Domain from Pept1 and Pept2 Provide Novel Insights Into Mammalian Peptide Transport Structure, 23, 2015
7PWF	Cryo-EM structure of small subunit of Giardia lamblia ribosome at 2.9 A resolution 分子名称: 40S ribosomal protein S21, 40S ribosomal protein S25, 40S ribosomal protein S26, ... 著者 Hiregange, D.G, Rivalta, A, Bose, T, Breiner-Goldstein, E, Samiya, S, Cimicata, G, Kulakova, L, Zimmerman, E, Bashan, A, Herzberg, O, Yonath, A. 登録日 2021-10-06 公開日 2022-05-25 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia. Nucleic Acids Res., 50, 2022
7W6P	Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist 分子名称: Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. 登録日 2021-12-02 公開日 2022-09-28 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
7W7E	Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist 分子名称: 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. 登録日 2021-12-04 公開日 2022-09-28 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
7C38	Crystal structure of AofleA from Arthrobotrys oligospora in complex with L-fucose 分子名称: AofleA, GLYCEROL, alpha-L-fucopyranose, ... 著者 Liu, M, Cheng, X, Wang, J, Zhang, M, Wang, M. 登録日 2020-05-11 公開日 2020-07-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structural insights into the fungi-nematodes interaction mediated by fucose-specific lectin AofleA from Arthrobotrys oligospora. Int.J.Biol.Macromol., 164, 2020
8HQY	Cryo-EM structure of SSX1 bound to the H2AK119Ub nucleosome at a resolution of 3.05 angstrom 分子名称: DNA (136-MER), DNA (137-MER), Histone H2A type 1-B/E, ... 著者 Zebin, T, Ai, H.S, Ziyu, X, GuoChao, C, Man, P, Liu, L. 登録日 2022-12-14 公開日 2023-09-27 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.05 Å) 主引用文献 Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes. Nat.Struct.Mol.Biol., 31, 2024
6ZDE	17beta-hydroxysteroid dehydrogenase type 14 variant S205 in complex with pentafluorophenol 分子名称: 17-beta-hydroxysteroid dehydrogenase 14, 2,3,4,5,6-pentakis(fluoranyl)phenol, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Badran, M.J, Heine, A, Klebe, G. 登録日 2020-06-14 公開日 2021-01-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 17beta-hydroxysteroid dehydrogenase type 14 variant S205 in complex with pentafluorophenol To Be Published

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