3G3Q
 
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5C3B
 | | Crystal structure of ABBA + UDP-C-Gal (long soak) + DI | | 分子名称: | (((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)phosphonic (((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphoric) anhydride, Histo-blood group ABO system transferase, MANGANESE (II) ION, ... | | 著者 | Gagnon, S, Meloncelli, P, Zheng, R.B, Haji-Ghassemi, O, Johal, A.R, Borisova, S, Lowary, T.L, Evans, S.V. | | 登録日 | 2015-06-17 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | High Resolution Structures of the Human ABO(H) Blood Group Enzymes in Complex with Donor Analogs Reveal That the Enzymes Utilize Multiple Donor Conformations to Bind Substrates in a Stepwise Manner.
J.Biol.Chem., 290, 2015
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5C47
 | | Crystal structure of ABBB + UDP-C-Gal (long soak) + DI | | 分子名称: | (((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)phosphonic (((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphoric) anhydride, 2-(2-METHOXYETHOXY)ETHANOL, Histo-blood group ABO system transferase, ... | | 著者 | Gagnon, S, Meloncelli, P, Zheng, R.B, Haji-Ghassemi, O, Johal, A.R, Borisova, S, Lowary, T.L, Evans, S.V. | | 登録日 | 2015-06-17 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | High Resolution Structures of the Human ABO(H) Blood Group Enzymes in Complex with Donor Analogs Reveal That the Enzymes Utilize Multiple Donor Conformations to Bind Substrates in a Stepwise Manner.
J.Biol.Chem., 290, 2015
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3G3U
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6U6X
 | | Human SAMHD1 bound to deoxyribo(C*G*C*C*T)-oligonucleotide | | 分子名称: | DNA SC-GS-SC-SC-DT, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION | | 著者 | Taylor, A.B, Bhattacharya, A, Wang, Z, Ivanov, D.N. | | 登録日 | 2019-08-30 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Nat Commun, 12, 2021
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1GT8
 | | DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND URACIL-4-ACETIC ACID | | 分子名称: | DIHYDROPYRIMIDINE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Dobritzsch, D, Ricagno, S, Schneider, G, Schnackerz, K.D, Lindqvist, Y. | | 登録日 | 2002-01-14 | | 公開日 | 2002-04-11 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer.
J. Biol. Chem., 277, 2002
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1GTE
 | | DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, BINARY COMPLEX WITH 5-IODOURACIL | | 分子名称: | 5-IODOURACIL, DIHYDROPYRIMIDINE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... | | 著者 | Dobritzsch, D, Ricagno, S, Schneider, G, Schnackerz, K.D, Lindqvist, Y. | | 登録日 | 2002-01-15 | | 公開日 | 2002-04-11 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer.
J. Biol. Chem., 277, 2002
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3G3T
 | | Crystal structure of a eukaryotic polyphosphate polymerase in complex with orthophosphate | | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, Vacuolar transporter chaperone 4 | | 著者 | Lenherr, E.D, Hothorn, M, Scheffzek, K. | | 登録日 | 2009-02-02 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.
Science, 324, 2009
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3G3R
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4JTA
 | | Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | | 著者 | MacKinnon, R, Banerjee, A, Lee, A, Campbell, E. | | 登録日 | 2013-03-23 | | 公開日 | 2013-06-12 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
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5YZV
 | | Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA | | 分子名称: | Probable serine/threonine-protein kinase PkwA | | 著者 | Li, D.Y, Shen, C, Du, Y, Qiao, F.F, Kong, T, Yuan, L.R, Zhang, D.L, Wu, X.H, Wu, Y.D. | | 登録日 | 2017-12-15 | | 公開日 | 2018-10-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA
Sci Rep, 8, 2018
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4HDO
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6UWT
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3JCS
 | | 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania | | 分子名称: | 26S alpha ribosomal RNA, 26S delta ribosomal RNA, 26S epsilon ribosomal RNA, ... | | 著者 | Shalev-Benami, M, Zhang, Y, Matzov, D, Halfon, Y, Zackay, A, Rozenberg, H, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G. | | 登録日 | 2016-01-21 | | 公開日 | 2016-07-20 | | 最終更新日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | 2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Cell Rep, 16, 2016
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4WRB
 | | Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-190) | | 分子名称: | 4-{4-[6-(2-methoxyethoxy)quinolin-2-yl]-1H-1,2,3-triazol-1-yl}phenol, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L. | | 登録日 | 2014-10-23 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor.
J.Am.Chem.Soc., 137, 2015
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8R35
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8R34
 | | CryoEM structure of the symmetric Pho90 dimer from yeast with substrates. | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, Low-affinity phosphate transporter PHO90, PHOSPHATE ION, ... | | 著者 | Schneider, S, Kuehlbrandt, W, Yildiz, O. | | 登録日 | 2023-11-08 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | | 主引用文献 | Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism.
Structure, 32, 2024
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4WR8
 | | Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-180) | | 分子名称: | 4-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]phenol, Macrophage migration inhibitory factor, SODIUM ION, ... | | 著者 | Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L. | | 登録日 | 2014-10-23 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor.
J.Am.Chem.Soc., 137, 2015
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1XZU
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1GTH
 | | DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND 5-IODOURACIL | | 分子名称: | (5S)-5-IODODIHYDRO-2,4(1H,3H)-PYRIMIDINEDIONE, 5-IODOURACIL, DIHYDROPYRIMIDINE DEHYDROGENASE, ... | | 著者 | Dobritzsch, D, Ricagno, S, Schneider, G, Schnackerz, K.D, Lindqvist, Y. | | 登録日 | 2002-01-15 | | 公開日 | 2002-04-11 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer.
J. Biol. Chem., 277, 2002
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6RD5
 | | CryoEM structure of Polytomella F-ATP synthase, focussed refinement of Fo and peripheral stalk, C2 symmetry | | 分子名称: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ATP synthase associated protein ASA1, ... | | 著者 | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | | 登録日 | 2019-04-12 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling.
Science, 364, 2019
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7U1N
 | | Crystal structure of the Anopheles darlingi AD-118 long form D7 salivary protein | | 分子名称: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, 2-ETHOXYETHANOL, ... | | 著者 | Alvarenga, P.H, Gittis, A.G, Garboczi, D.N, Andersen, J.F. | | 登録日 | 2022-02-21 | | 公開日 | 2022-05-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes.
Insect Biochem.Mol.Biol., 146, 2022
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5VG9
 | | Structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine carboxyl methyltransferase) without a monobody | | 分子名称: | Protein-S-isoprenylcysteine O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Long, S.B, Diver, M.M, Pedi, L, Koide, A, Koide, S. | | 登録日 | 2017-04-10 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT.
Nature, 553, 2018
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8R33
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6RD4
 | | CryoEM structure of Polytomella F-ATP synthase, Full dimer, composite map | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | | 著者 | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | | 登録日 | 2019-04-12 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling.
Science, 364, 2019
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