PDB: 10970 件ウェブページステータス検索Chemie searchBIRD

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1XH9	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 分子名称: (R,R)-2,3-BUTANEDIOL, N-[4-({4-[5-(DIMETHYLAMINO)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, ... 著者 Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. 登録日 2004-09-17 公開日 2005-09-17 最終更新日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
1BQQ	CRYSTAL STRUCTURE OF THE MT1-MMP--TIMP-2 COMPLEX 分子名称: CALCIUM ION, MEMBRANE-TYPE MATRIX METALLOPROTEINASE, METALLOPROTEINASE INHIBITOR 2, ... 著者 Fernandez-Catalan, C, Bode, W, Huber, R, Turk, D, Calvete, J.J, Lichte, A, Tschesche, H, Maskos, K. 登録日 1998-08-18 公開日 1999-08-18 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor. EMBO J., 17, 1998
8DYA	Structure of the SARS-CoV-2 spike glycoprotein S2 subunit 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein 著者 Park, Y.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 登録日 2022-08-03 公開日 2022-11-30 最終更新日 2023-01-11 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines. Sci Immunol, 7, 2022
8T1T	Structure of the alpha-N-methyltransferase (SonM) and RiPP precursor (SonA with QSY deletion) heteromeric complex (bound to SAM) 分子名称: Alpha-N-methyltransferase (SonM), RiPP precursor (SonA), S-ADENOSYLMETHIONINE, ... 著者 Crone, K.K, Jomori, T, Miller, F.S, Gralnick, J, Elias, M, Freeman, M.F. 登録日 2023-06-03 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin alpha- N -methylated peptide natural product. Rsc Chem Biol, 4, 2023
8SKJ	Crystal structure of a Nanobody bound to the V5 peptide. 分子名称: NbA1, V5 Epitope Tag Peptide 著者 Zaghal, M, Matte, K, Venes, A, Patel, S, Laroche, G, Sarvan, S, Joshi, M, Couture, J.F, Giguere, P.M. 登録日 2023-04-19 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Development of a V5-tag-directed nanobody and its implementation as an intracellular biosensor of GPCR signaling. J.Biol.Chem., 299, 2023
8T1S	Structure of the alpha-N-methyltransferase (SonM) and RiPP precursor (SonA with QSY deletion) heteromeric complex (bound to SAH) 分子名称: Alpha-N-methyltransferase, Extradiol ring-cleavage dioxygenase LigAB LigA subunit domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Crone, K.K, Jomori, T, Miller, F.S, Gralnick, J, Elias, M, Freeman, M.F. 登録日 2023-06-03 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin alpha- N -methylated peptide natural product. Rsc Chem Biol, 4, 2023
7QAN	Cytochrome P450 Enzyme AbyV 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CHLORIDE ION, Cytochrome P450, ... 著者 Parnell, A.E, Back, C.R, Race, P.R. 登録日 2021-11-17 公開日 2022-11-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis. Angew.Chem.Int.Ed.Engl., 62, 2023
6PLH	FAB fragment complexed with C-mannosylated tryptophan peptide 分子名称: Fab 5G12 heavy chain, Fab 5G12 light chain, Interleukin-21 receptor, ... 著者 John, A, Jarva, M.A, Goddard-Borger, E.D. 登録日 2019-06-30 公開日 2020-07-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Yeast- and antibody-based tools for studying tryptophan C-mannosylation. Nat.Chem.Biol., 17, 2021
6POM	Cryo-EM structure of the full-length Bacillus subtilis glyQS T-box riboswitch in complex with tRNA-Gly 分子名称: T-box GlyQS leader (155-MER), tRNAGly (75-MER) 著者 Li, S, Su, Z, Zhang, J, Chiu, W. 登録日 2019-07-04 公開日 2019-11-20 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions. Nat.Struct.Mol.Biol., 26, 2019
8DUT	Duplex-G-quadruplex-duplex (DGD) class_1 分子名称: Duplex-G-quadruplex-duplex (46-MER) 著者 Monsen, R.C, Chua, E.Y.D, Hopkins, J.B, Chaires, J.B, Trent, J.O. 登録日 2022-07-27 公開日 2023-02-08 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (7.4 Å) 主引用文献 Structure of a 28.5 kDa duplex-embedded G-quadruplex system resolved to 7.4 angstrom resolution with cryo-EM. Nucleic Acids Res., 51, 2023
6PY8	Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA 分子名称: DNA, Neurogenic locus notch homolog protein 1, Notch-regulated ankyrin repeat-containing protein, ... 著者 Jarrett, S.M, Seegar, T.C.M, Blacklow, S.C. 登録日 2019-07-29 公開日 2019-08-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.75 Å) 主引用文献 Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci.Signal., 12, 2019
8SVC	Crystal Structure of SBP from Klebsiella pneumoniae 分子名称: Metal ABC transporter substrate-binding protein, SULFATE ION, ZINC ION 著者 Giles, M.W, Cole, G.B, Ng, D, McDevitt, C.A, Moraes, T.F. 登録日 2023-05-16 公開日 2024-01-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Zinc acquisition and its contribution to Klebsiella pneumoniae virulence. Front Cell Infect Microbiol, 13, 2023
8DUF	Crystal structure of Venezuelan Equine Encephalitis alphavirus (VEEV) nonstructural protein 2 (nsp2) (K741A/K767A) protease domain 分子名称: nsp2 protease domain 著者 Lountos, G.T. 登録日 2022-07-27 公開日 2023-03-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Self-inhibited State of Venezuelan Equine Encephalitis Virus (VEEV) nsP2 Cysteine Protease: A Crystallographic and Molecular Dynamics Analysis. J.Mol.Biol., 435, 2023
8DZ8	Neoleukin 4, a de novo designed IL-4 mimetic 分子名称: neoleukin-4 著者 Jude, K.M, Spangler, J.B, Garcia, K.C. 登録日 2022-08-06 公開日 2023-03-29 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.972 Å) 主引用文献 Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds. Nat.Chem.Biol., 19, 2023
8E5T	Yeast co-transcriptional Noc1-Noc2 RNP assembly checkpoint intermediate 分子名称: 25S ribosomal RNA, 5.8S ribosomal RNA, 60S ribosomal protein L13-A, ... 著者 Sanghai, Z.A, Piwowarczyk, R, Vanden Broeck, A, Klinge, S. 登録日 2022-08-22 公開日 2023-04-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 A co-transcriptional ribosome assembly checkpoint controls nascent large ribosomal subunit maturation. Nat.Struct.Mol.Biol., 30, 2023
8QX2	Aplysia californica acetylcholine-binding protein in complex with racemic spiroimine (+)/(-)-4 分子名称: ISOPROPYL ALCOHOL, Soluble acetylcholine receptor, Spiroimine (+)-4 R 著者 Sulzenbacher, G, Bourne, Y, Marchot, P. 登録日 2023-10-20 公開日 2024-04-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The Cyclic Imine Core Common to the Marine Macrocyclic Toxins Is Sufficient to Dictate Nicotinic Acetylcholine Receptor Antagonism. Mar Drugs, 22, 2024
8PWX	PfRH5 bound to monoclonal antibody R5.008 分子名称: GLYCEROL, Reticulocyte-binding protein homolog 5, scFv fragment for antibody R5.008 著者 Farrell, B, Higgins, M.K. 登録日 2023-07-21 公開日 2024-06-05 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 PfRH5 bound to monoclonal antibody R5.008 To Be Published
6Q7P	Crystal structure of OE1.2 分子名称: 1,2-ETHANEDIOL, 1-PHENYLETHANONE, MAGNESIUM ION, ... 著者 Levy, C.W. 登録日 2018-12-13 公開日 2019-06-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Design and evolution of an enzyme with a non-canonical organocatalytic mechanism. Nature, 570, 2019
7RK8	Cryo-EM Structure of Adeno-Associated Virus Serotype 9 with Engineered Peptide Domain PHP.B (AAV9-PHP.B) 分子名称: Capsid protein VP1 著者 Fluck, E.C, Pumroy, R.A, Moiseenkova-Bell, V.Y. 登録日 2021-07-22 公開日 2021-08-04 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.27 Å) 主引用文献 Context-Specific Function of the Engineered Peptide Domain of PHP.B. J.Virol., 95, 2021
2VDC	THE 9.5 A RESOLUTION STRUCTURE OF GLUTAMATE SYNTHASE FROM CRYO-ELECTRON MICROSCOPY AND ITS OLIGOMERIZATION BEHAVIOR IN SOLUTION: FUNCTIONAL IMPLICATIONS. 分子名称: 2-OXOGLUTARIC ACID, FE3-S4 CLUSTER, FLAVIN MONONUCLEOTIDE, ... 著者 Cottevieille, M, Larquet, E, Jonic, S, Petoukhov, M.V, Caprini, G, Paravisi, S, Svergun, D.I, Vanoni, M.A, Boisset, N. 登録日 2007-10-04 公開日 2008-01-15 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (9.5 Å) 主引用文献 The Subnanometer Resolution Structure of the Glutamate Synthase 1.2-Mda Hexamer by Cryoelectron Microscopy and its Oligomerization Behavior in Solution: Functional Implications. J.Biol.Chem., 283, 2008
2VGC	GAMMA-CHYMOTRYPSIN D-PARA-CHLORO-1-ACETAMIDO BORONIC ACID INHIBITOR COMPLEX 分子名称: D-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID, GAMMA CHYMOTRYPSIN, SULFATE ION 著者 Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F. 登録日 1997-05-01 公開日 1997-11-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes. Biochemistry, 37, 1998
7RK9	Cryo-EM Structure of Adeno-Associated Virus Serotype 1 with Engineered Peptide Domain PHP.B (AAV1-PHP.B) 分子名称: Capsid protein 著者 Fluck, E.C, Pumroy, R.A, Moiseenkova-Bell, V.Y. 登録日 2021-07-22 公開日 2021-08-04 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.32 Å) 主引用文献 Context-Specific Function of the Engineered Peptide Domain of PHP.B. J.Virol., 95, 2021
1XH8	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 分子名称: N-[4-({4-[5-(4,4-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... 著者 Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. 登録日 2004-09-17 公開日 2005-09-17 最終更新日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
6Q7R	Crystal structure of OE1.3 alkylated with the mechanistic inhibitor 2-bromoacetophenone 分子名称: 1-PHENYLETHANONE, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Levy, C.W. 登録日 2018-12-13 公開日 2019-06-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Design and evolution of an enzyme with a non-canonical organocatalytic mechanism. Nature, 570, 2019
1XH6	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 分子名称: N-(4-{[4-(2-HYDROXY-5-PIPERIDIN-1-YLBENZOYL)BENZOYL]AMINO}AZEPAN-3-YL)ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... 著者 Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. 登録日 2004-09-17 公開日 2005-09-17 最終更新日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005

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