PDB: 222415 件ウェブページステータス検索Chemie searchBIRD

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4V7M	The structures of Capreomycin bound to the 70S ribosome. 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Stanley, R.E, Blaha, G. 登録日 2009-11-12 公開日 2014-07-09 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome. Nat.Struct.Mol.Biol., 17, 2010
6D9X	Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design 分子名称: 2-phenyl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole, SODIUM ION, WD repeat-containing protein 5 著者 Phan, J, Fesik, S.W. 登録日 2018-04-30 公開日 2018-09-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J. Med. Chem., 61, 2018
5K58	Structure of the K. pneumonia SlmA-DNA complex bound to the C-terminal of the cell division protein FtsZ 分子名称: DNA (5'-D(*GP*TP*GP*AP*GP*TP*AP*CP*TP*CP*AP*C)-3'), Nucleoid occlusion factor SlmA, Octapeptide 著者 Schumacher, M. 登録日 2016-05-23 公開日 2016-06-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.772 Å) 主引用文献 Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
7XLD	Crystal structure of IsdH linker-NEAT3 bound to a nanobody (VHH) 分子名称: Iron-regulated surface determinant protein H, MAGNESIUM ION, Nanobody VHH6, ... 著者 Caaveiro, J.M.M, Valenciano-Bellido, S, Tsumoto, K. 登録日 2022-04-21 公開日 2023-05-31 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Targeting hemoglobin receptors IsdH and IsdB of Staphylococcus aureus with a single VHH antibody inhibits bacterial growth. J.Biol.Chem., 299, 2023
5K7A	Crystal structure of laccase fron Thermus thermophilus HB27 (sodium nitrate 1.5 min) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, COPPER (II) ION, Laccase 著者 Diaz-Vilchis, A, Ruiz-Arellano, R.R, Rosas-Benitez, E, Rudino-Pinera, E. 登録日 2016-05-25 公開日 2017-06-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Preserving metalic sites affected by radiation damage: the CuT2 case in Thermus thermophilus multicopper oxidase To be Published
6D4F	Crystal structure of PTP epsilon D2 domain (A455N/V457Y/E597D) 分子名称: PENTAETHYLENE GLYCOL, Receptor-type tyrosine-protein phosphatase epsilon 著者 Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S. 登録日 2018-04-18 公開日 2018-10-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.909 Å) 主引用文献 High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design. Acta Crystallogr D Struct Biol, 74, 2018
6DBK	Tyk2 with compound 8 分子名称: 4-({4-[(1S,4S)-5-(cyanoacetyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyrimidin-2-yl}amino)-N-ethylbenzamide, Non-receptor tyrosine-protein kinase TYK2 著者 Vajdos, F.F. 登録日 2018-05-03 公開日 2018-08-29 最終更新日 2018-11-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J. Med. Chem., 61, 2018
6D4R	M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 18 (VCC399134) 分子名称: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, hydroxy(3-{4-[(isoquinolin-5-yl)sulfonyl]piperazine-1-carbonyl}phenyl)oxoammonium 著者 Ascher, D.B, Pacitto, A, Blundell, T.L. 登録日 2018-04-18 公開日 2019-05-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH. Eur.J.Med.Chem., 174, 2019
6D55	Ras:SOS:Ras in complex with a small molecule activator 分子名称: 6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpiperazin-1-yl)-1H-benzimidazole, FORMIC ACID, GLYCEROL, ... 著者 Phan, J, Hodges, T, Fesik, S.W. 登録日 2018-04-19 公開日 2018-09-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J. Med. Chem., 61, 2018
5K92	Crystal Structure of an apo Tris-thiolate Binding Site in a de novo Three Stranded Coiled Coil Peptide 分子名称: Apo-(CSL16C)3, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Ruckthong, L, Zastrow, M.L, Stuckey, J.A, Pecoraro, V.L. 登録日 2016-05-31 公開日 2016-08-31 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins. J.Am.Chem.Soc., 138, 2016
4U27	Crystal structure of the E. coli ribosome bound to flopristin and linopristin. 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Noeske, J, Huang, J, Olivier, N.B, Giacobbe, R.A, Zambrowski, M, Cate, J.H.D. 登録日 2014-07-16 公開日 2014-07-30 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Synergy of streptogramin antibiotics occurs independently of their effects on translation. Antimicrob.Agents Chemother., 58, 2014
6D5Y	Crystal structure of ERK2 G169D mutant 分子名称: Mitogen-activated protein kinase 1 著者 Yin, J, Jaiswal, B.S, Wang, W. 登録日 2018-04-19 公開日 2019-02-27 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy. Clin. Cancer Res., 24, 2018
6D74	Direct Activation of the Executioner Domain of MLKL by a Select Repertoire of Inositol Phosphates 分子名称: Mixed lineage kinase domain-like protein 著者 Royappa, G.C, McNamara, D.E, Moldoveanu, T. 登録日 2018-04-24 公開日 2019-05-15 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites. Cell Chem Biol, 26, 2019
6D53	Trans form of HemolysinII c-terminal domain 分子名称: Hemolysin II 著者 Kaplan, A.R, Alexandrescu, A.T, Olson, R. 登録日 2018-04-19 公開日 2019-04-24 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Trans form of HemolysinII c-terminal domain To Be Published
6D6B	The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 11 分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 2-nitrobenzoate, Transcriptional activator protein LasR 著者 Dong, S.H, Nair, S.K. 登録日 2018-04-20 公開日 2018-08-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR. Cell Chem Biol, 25, 2018
6D50	Bacteroides uniforms beta-glucuronidase 2 bound to D-glucaro-1,5-lactone 分子名称: (2S,3S,4S,5R)-3,4,5-trihydroxy-6-oxo-oxane-2-carboxylic acid, CALCIUM ION, Glycosyl hydrolases family 2, ... 著者 Walton, W.G, Pellock, S.J, Redinbo, M.R. 登録日 2018-04-19 公開日 2018-10-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis. J. Biol. Chem., 293, 2018
6D7N	Crystal structure of the W357R/W399R Importin alpha mutant 分子名称: 1,2-ETHANEDIOL, Peroxidase,Importin subunit alpha-1 著者 Pedersen, L.C, London, R.E, Gabel, S.A. 登録日 2018-04-25 公開日 2019-03-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Variations in nuclear localization strategies among pol X family enzymes. Traffic, 2018
6D7S	Cryo-EM structure of human TRPV6-Y467A in amphipols 分子名称: Transient receptor potential cation channel subfamily V member 6 著者 Singh, A.K, Saotome, K, McGoldrick, L.L, Sobolevsky, A.I. 登録日 2018-04-25 公開日 2018-07-18 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.34 Å) 主引用文献 Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB. Nat Commun, 9, 2018
6D8O	Group I self-splicing intron P4-P6 domain mutant A230U 分子名称: Group I self-splicing intron, MAGNESIUM ION 著者 Shoffner, G.M. 登録日 2018-04-26 公開日 2018-07-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.80112481 Å) 主引用文献 In Crystallo Selection to Establish New RNA Crystal Contacts. Structure, 26, 2018
6D6C	The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 12 分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 2-methoxybenzoate, HISTIDINE, Transcriptional activator protein LasR 著者 Dong, S.H, Nair, S.K. 登録日 2018-04-20 公開日 2018-08-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR. Cell Chem Biol, 25, 2018
7XEX	Crystal strucutre of apoCasDinG 分子名称: CasDinG 著者 Zhang, J.T, Cui, N, Liu, Y.R, Huang, H.D, Jia, N. 登録日 2022-03-31 公開日 2023-07-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
7XF1	Crystal strucutre of apoCasDinG in complex with ssDNA 分子名称: CasDinG, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3') 著者 Zhang, J.T, Cui, N, Liu, Y.R, Huang, H.D, Jia, N. 登録日 2022-03-31 公開日 2023-07-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
5KD0	Crystal structure of the aromatic prenyltransferase AtaPT(E91A) mutant from Aspergillus terreus A8-4 in complex with geranyl S-thiolodiphosphate and (+)-butyrolactone II 分子名称: GERANYL S-THIOLODIPHOSPHATE, aromatic prenyltransferase, methyl (2~{R})-3-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-4-oxidanyl-5-oxidanylidene-furan-2-carboxylate 著者 Sun, F, Gao, B. 登録日 2016-06-07 公開日 2016-12-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nat. Chem. Biol., 13, 2017
6D4U	M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 27 (VCC663664) 分子名称: 2-(2,4-dimethoxyphenyl)-1-{4-[(isoquinolin-5-yl)sulfonyl]piperazin-1-yl}ethan-1-one, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase 著者 Ascher, D.B, Pacitto, A, Blundell, T.L. 登録日 2018-04-18 公開日 2019-05-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH. Eur.J.Med.Chem., 174, 2019
6D5U	Hexagonal thermolysin cryocooled to 100 K with 50% methanol as cryoprotectant 分子名称: CALCIUM ION, LYSINE, METHANOL, ... 著者 Juers, D.H. 登録日 2018-04-19 公開日 2018-09-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.00009537 Å) 主引用文献 The impact of cryosolution thermal contraction on proteins and protein crystals: volumes, conformation and order. Acta Crystallogr D Struct Biol, 74, 2018

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