6D4U
M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 27 (VCC663664)
Summary for 6D4U
Entry DOI | 10.2210/pdb6d4u/pdb |
Descriptor | Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, 2-(2,4-dimethoxyphenyl)-1-{4-[(isoquinolin-5-yl)sulfonyl]piperazin-1-yl}ethan-1-one, ... (4 entities in total) |
Functional Keywords | complex, fragment, impdh, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mycobacterium thermoresistibile More |
Total number of polymer chains | 1 |
Total formula weight | 40658.21 |
Authors | Ascher, D.B.,Pacitto, A.,Blundell, T.L. (deposition date: 2018-04-18, release date: 2019-05-01, Last modification date: 2023-10-04) |
Primary citation | Singh, V.,Pacitto, A.,Donini, S.,Ferraris, D.M.,Boros, S.,Illyes, E.,Szokol, B.,Rizzi, M.,Blundell, T.L.,Ascher, D.B.,Pato, J.,Mizrahi, V. Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH. Eur.J.Med.Chem., 174:309-329, 2019 Cited by PubMed: 31055147DOI: 10.1016/j.ejmech.2019.04.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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