4UCS
 
 | | Fragment bound to H.influenza NAD dependent DNA ligase | | 分子名称: | 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide, DNA LIGASE | | 著者 | Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. | | 登録日 | 2014-12-04 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors
Tetrahedron Lett., 56, 2015
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4UCO
 | | Fragment bound to H.influenza NAD dependent DNA ligase | | 分子名称: | 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide, DNA LIGASE | | 著者 | Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. | | 登録日 | 2014-12-04 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors
Tetrahedron Lett., 56, 2015
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4UCV
 | | Fragment bound to H.influenza NAD dependent DNA ligase | | 分子名称: | 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 8-methoxy-2,3-dimethylquinoxalin-5-ol, DNA LIGASE | | 著者 | Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. | | 登録日 | 2014-12-04 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors
Tetrahedron Lett., 56, 2015
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4UCR
 | | Fragment bound to H.influenza NAD dependent DNA ligase | | 分子名称: | 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 8-hydroxy-2-methylquinoline-6-carboxamide, DNA LIGASE | | 著者 | Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. | | 登録日 | 2014-12-04 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors
Tetrahedron Lett., 56, 2015
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4V7F
 | | Arx1 pre-60S particle. | | 分子名称: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | 著者 | Leidig, C, Thoms, M, Holdermann, I, Bradatsch, B, Berninghausen, O, Bange, G, Sinning, I, Hurt, E, Beckmann, R. | | 登録日 | 2013-12-10 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (8.7 Å) | | 主引用文献 | 60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.
Nat Commun, 5, 2014
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4V1A
 | | Structure of the large subunit of the mammalian mitoribosome, part 2 of 2 | | 分子名称: | MITORIBOSOMAL PROTEIN ML37, MRPL37, MITORIBOSOMAL PROTEIN ML38, ... | | 著者 | Greber, B.J, Boehringer, D, Leibundgut, M, Bieri, P, Leitner, A, Schmitz, N, Aebersold, R, Ban, N. | | 登録日 | 2014-09-25 | | 公開日 | 2014-10-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | The Complete Structure of the Large Subunit of the Mammalian Mitochondrial Ribosome
Nature, 515, 2014
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4V5H
 | | E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide. | | 分子名称: | 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | | 著者 | Seidelt, B, Innis, C.A, Wilson, D.N, Gartmann, M, Armache, J, Villa, E, Trabuco, L.G, Becker, T, Mielke, T, Schulten, K, Steitz, T.A, Beckmann, R. | | 登録日 | 2009-10-26 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | | 主引用文献 | Structural insight into nascent polypeptide chain-mediated translational stalling.
Science, 326, 2009
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4V4G
 | | Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y. | | 分子名称: | 16S ribosomal RNA, 23S RIBOSOMAL RNA, 30S ribosomal protein S10, ... | | 著者 | Vila-Sanjurjo, A, Schuwirth, B.S, Hau, C.W, Cate, J.H. | | 登録日 | 2004-10-06 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (11.5 Å) | | 主引用文献 | Structural basis for the control of translation initiation during stress.
Nat.Struct.Mol.Biol., 11, 2004
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4W55
 | | T4 Lysozyme L99A with n-Propylbenzene Bound | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Endolysin, propylbenzene | | 著者 | Merski, M, Shoichet, B.K, Eidam, O, Fischer, M. | | 登録日 | 2014-08-16 | | 公開日 | 2015-04-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.6401 Å) | | 主引用文献 | Homologous ligands accommodated by discrete conformations of a buried cavity.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4W58
 | | T4 Lysozyme L99A with n-Pentylbenzene Bound | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Endolysin, pentylbenzene | | 著者 | Merski, M, Shoichet, B.K, Eidam, O, Fischer, M. | | 登録日 | 2014-08-16 | | 公開日 | 2015-04-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Homologous ligands accommodated by discrete conformations of a buried cavity.
Proc.Natl.Acad.Sci.USA, 112, 2015
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9EUP
 | | Inhibitor-free outward-open structure of Drosophila dopamine transporter | | 分子名称: | 9D5 ANTIBODY, HEAVY CHAIN, LIGHT CHAIN, ... | | 著者 | Pedersen, C.N, Yang, F, Ita, S, Xu, Y, Akunuri, R, Trampari, S, Neumann, C.M.T, Desdorf, L.M, Schioett, B, Salvino, J.M, Mortensen, O.V, Nissen, P, Shahsavar, A. | | 登録日 | 2024-03-27 | | 公開日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.
J.Neurochem., 2024
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2AVA
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9C83
 | | X-ray crystal structure of AmpC beta-lactamase with inhibitor | | 分子名称: | AmpC Beta-lactamase, N-[(3M)-3-(5-chloro-1,2,3-thiadiazol-4-yl)phenyl]-5-methyl-3-oxo-2,3-dihydro-1,2-oxazole-4-sulfonamide | | 著者 | Liu, F, Shoichet, B.K. | | 登録日 | 2024-06-11 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase
To Be Published
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9ER3
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9BEI
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8YRG
 | | CryoEM structure of fospropofol-bound MRGPRX4-Gq complex | | 分子名称: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Cao, C, Fay, J.F, Roth, B.L. | | 登録日 | 2024-03-21 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model.
Sci Transl Med, 16, 2024
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9FWC
 | | Coxsackievirus B3 3C protease in C121 spacegroup | | 分子名称: | Genome polyprotein | | 著者 | Fairhead, M, Lithgo, R.M, MacLean, E.M, Bowesman-Jones, H, Aschenbrenner, J.C, Balcomb, B.H, Capkin, E, Chandran, A.V, Godoy, A.S, Marples, P.G, Fearon, D, von Delft, F, Koekemoer, L. | | 登録日 | 2024-06-28 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Coxsackievirus B3 3C protease in C121 spacegroup
To Be Published
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9CK3
 | | Cryo-EM structure of in-vitro alpha-synuclein fibril | | 分子名称: | Alpha-synuclein | | 著者 | Sanchez, J.C, Borcik, C.G, Tonelli, M, Sibert, B, Rienstra, C.M, Wright, E.R. | | 登録日 | 2024-07-08 | | 公開日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.04 Å) | | 主引用文献 | Multimodal High-Resolution Structure Determination Of Alpha-Synuclein Fibrils
To Be Published
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9C8J
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9FQ2
 | | Poliovirus 3C protease in H32 spacegroup | | 分子名称: | Protease 3C | | 著者 | Fairhead, M, Lithgo, R.M, MacLean, E.M, Bowesman-Jones, H, Aschenbrenner, J.C, Balcomb, B.H, Capkin, E, Chandran, A.V, Godoy, A.S, Marples, P.G, Fearon, D, von Delft, F, Koekemoer, L. | | 登録日 | 2024-06-14 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Poliovirus 3C protease in H32 spacegroup
To Be Published
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8YC0
 | | T cell receptor V delta2 V gamma9 in GDN | | 分子名称: | CHOLESTEROL, T cell receptor delta variable 2,T cell receptor delta constant, T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | | 著者 | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | 登録日 | 2024-02-17 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.12 Å) | | 主引用文献 | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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9C6P
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2AJE
 | | Solution structure of the Arabidopsis thaliana telomeric repeat-binding protein DNA binding domain | | 分子名称: | telomere repeat-binding protein | | 著者 | Hsiao, H.H, Sue, S.C, Chung, B.C, Cheng, Y.H, Huang, T.H. | | 登録日 | 2005-08-01 | | 公開日 | 2006-07-04 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the Arabidopsis thaliana telomeric repeat-binding protein DNA binding domain: a new fold with an additional C-terminal helix
J.Mol.Biol., 356, 2006
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9C84
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9C81
 | | X-ray crystal structure of AmpC beta-lactamase with inhibitor | | 分子名称: | (2R)-2-phenoxy-3-{[(1S,2S,4S)-spiro[bicyclo[2.2.1]heptane-7,1'-cyclopropane]-2-carbonyl]amino}propanoic acid, AmpC Beta-lactamase | | 著者 | Liu, F, Shoichet, B.K, Bassim, V. | | 登録日 | 2024-06-11 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase
To Be Published
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