PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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6P7W	Structure of the K. lactis CBF3 core - Ndc10 D1 complex 分子名称: Cep3, Ctf13, Ndc10, ... 著者 Lee, P.D, Wei, H, Tan, D, Harrison, S.C. 登録日 2019-06-06 公開日 2019-09-18 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structure of the Centromere Binding Factor 3 Complex from Kluyveromyces lactis. J.Mol.Biol., 431, 2019
7Z8V	CAND1-SCF-SKP2 (SKP1deldel) CAND1 engaged SCF rocked 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-18 公開日 2023-04-19 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
6P38	Crystal Structure Analysis of TAF1 Bromodomain 分子名称: 4-{[(3R)-4-cyclopentyl-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl]amino}-N-(1-methylpiperidin-4-yl)-3-[(propan-2-yl)oxy]benzamide, Transcription initiation factor TFIID subunit 1 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2019-05-23 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold. Acs Med.Chem.Lett., 10, 2019
6P7V	Structure of the K. lactis CBF3 core 分子名称: Cep3, Ctf13, Skp1 著者 Lee, P.D, Wei, H, Tan, D, Harrison, S.C. 登録日 2019-06-06 公開日 2019-09-11 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure of the Centromere Binding Factor 3 Complex from Kluyveromyces lactis. J.Mol.Biol., 431, 2019
6FLE	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Gelin, M, Labesse, G. 登録日 2018-01-25 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Crystal structure of ERK2 in complex with an adenosine derivative To be published
6PG6	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acetamide 分子名称: CHLORIDE ION, N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}acetamide, SULFATE ION, ... 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
4Y7R	Crystal structure of WDR5 in complex with MYC MbIIIb peptide 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MYC MbIIIb peptide, ... 著者 Sun, Q, Phan, J, Olejniczak, E.T, Thomas, L.R, Fesik, S.W, Tansey, W.P. 登録日 2015-02-16 公開日 2015-04-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.898 Å) 主引用文献 Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC. Mol.Cell, 58, 2015
6FJ0	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: 5'-deoxy-5'-(prop-2-yn-1-ylamino)adenosine, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Labesse, G. 登録日 2018-01-19 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.659 Å) 主引用文献 Crystal structure of ERK2 in complex with an adenosine derivative To be published
6PGF	WDR5delta32 bound to N-(4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acrylamide 分子名称: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}prop-2-enamide, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6FI6	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-azanyl-8-diazanyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Labesse, G. 登録日 2018-01-17 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of ERK2 in complex with an adenosine derivative To be published
6PG3	WDR5delta23 bound to (2-butyl-1H-imidazol-4-yl)methanol 分子名称: (2-butyl-1H-imidazol-4-yl)methanol, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG5	WDR5delta32 bound to benzyl (4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate 分子名称: SULFATE ION, WD repeat-containing protein 5, benzyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGB	WDR5delta32 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)-2-phenylacetamide 分子名称: N-{4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}-2-phenylacetamide, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6FRP	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: 5'-azido-5'-deoxyadenosine, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Labesse, G. 登録日 2018-02-16 公開日 2019-03-13 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 None To be published
6P7X	Structure of the K. lactis CBF3 core - Ndc10 D1D2 complex 分子名称: Cep3, Ctf13, Ndc10, ... 著者 Lee, P.D, Wei, H, Tan, D, Harrison, S.C. 登録日 2019-06-06 公開日 2019-09-18 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structure of the Centromere Binding Factor 3 Complex from Kluyveromyces lactis. J.Mol.Biol., 431, 2019
6FQ7	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: 4-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(azidomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]sulfanylbutanoic acid, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Labesse, G. 登録日 2018-02-13 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 None To be published
6PG8	WDR5delta23 bound to (2-(3-phenylpropyl)-1H-imidazol-4-yl)methanol 分子名称: CHLORIDE ION, SULFATE ION, WD repeat-containing protein 5, ... 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
2HFH	THE NMR STRUCTURES OF A WINGED HELIX PROTEIN: GENESIS, 20 STRUCTURES 分子名称: GENESIS 著者 Marsden, I, Jin, C, Liao, X. 登録日 1998-01-27 公開日 1998-06-17 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins. J.Mol.Biol., 278, 1998
6FMA	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: 3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(azidomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]sulfanylpropanoic acid, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Labesse, G. 登録日 2018-01-30 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.667 Å) 主引用文献 None To be published
6PG4	WDR5delta32 bound to (2-methyl-1H-imidazol-4-yl)methanol 分子名称: (2-methyl-1H-imidazol-4-yl)methanol, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG9	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)benzamide 分子名称: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}benzamide, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6G97	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-methoxyethyl)-3~{H}-isoindol-1-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2018-04-10 公開日 2018-05-30 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6G9H	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-methyl-ethanamide 著者 O'Reilly, M. 登録日 2018-04-10 公開日 2018-05-30 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6G9D	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]ethanamide 著者 O'Reilly, M. 登録日 2018-04-10 公開日 2018-05-30 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6G9M	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-(2-phenylpropan-2-yl)ethanamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2018-04-11 公開日 2018-05-30 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018

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