PDB: 10530 件ウェブページステータス検索Chemie searchBIRD

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8FG9	Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)pyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)pyridin-2-amine, ACETATE ION, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGJ	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)-4-methoxypyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{2-[5-(2-aminoethyl)-2,3-difluorophenyl]ethyl}-4-methylpyridin-2-amine, GLYCEROL, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGR	Structure of human endothelial nitric oxide synthase heme domain in complex with 6-(5-(2-aminoethyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{2-[5-(2-aminoethyl)-2,3-difluorophenyl]ethyl}-4-methylpyridin-2-amine, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGB	Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)-6-methylpyrimidin-2-amine 分子名称: 4-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)-6-methylpyrimidin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGH	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)-4-methoxypyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methoxypyridin-2-amine, GLYCEROL, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGT	Structure of human endothelial nitric oxide synthase heme domain in complex with 6-(2,3-difluoro-5-(2-(4-methylpiperazin-1-yl)ethyl)phenethyl)-4-methylpyridin-2-amine 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{2,3-difluoro-5-[2-(4-methylpiperazin-1-yl)ethyl]phenyl}ethyl)-4-methylpyridin-2-amine, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGM	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-(difluoromethyl)-6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)pyridin-2-amine 分子名称: 4-(difluoromethyl)-6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, GLYCEROL, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGA	Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methylpyridin-2-amine, ACETATE ION, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8947 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGK	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(5-(2-(diethylamino)ethyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{5-[2-(diethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methylpyridin-2-amine, GLYCEROL, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGU	Structure of human endothelial nitric oxide synthase heme domain in complex with 4-(difluoromethyl)-6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)pyridin-2-amine 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(difluoromethyl)-6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGD	Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-(5-(2-(diethylamino)ethyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{5-[2-(diethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methylpyridin-2-amine, ACETATE ION, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.776 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGP	Structure of human endothelial nitric oxide synthase heme domain in complex with 6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)-4-methoxypyridin-2-amine 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methoxypyridin-2-amine, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
8FGL	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(2,3-difluoro-5-(2-(4-methylpiperazin-1-yl)ethyl)phenethyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{2,3-difluoro-5-[2-(4-methylpiperazin-1-yl)ethyl]phenyl}ethyl)-4-methylpyridin-2-amine, GLYCEROL, ... 著者 Li, H, Poulos, T.L. 登録日 2022-12-12 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66, 2023
6V7L	The structure of the P212121 crystal form of canavalin at 173 K 分子名称: BENZOIC ACID, Canavalin 著者 McPherson, A. 登録日 2019-12-08 公開日 2020-02-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Binding of benzoic acid and anions within the cupin domains of the vicilin protein canavalin from jack bean (Canavalia ensiformis): Crystal structures. Biochem.Biophys.Res.Commun., 524, 2020
3IMV	Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromoaniline 分子名称: 4-[(E)-2-(4-aminophenyl)ethenyl]-2,6-dibromoaniline, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2009-08-11 公開日 2010-01-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J.Am.Chem.Soc., 132, 2010
5MWG	Crystal structure of the human BRPF1 bromodomain in complex with BZ091 分子名称: NITRATE ION, Peregrin, ~{N}-[1,4-dimethyl-2,3-bis(oxidanylidene)-7-piperidin-1-yl-quinoxalin-6-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide 著者 Zhu, J, Caflisch, A. 登録日 2017-01-18 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155, 2018
3IZ1	C-alpha model fitted into the EM structure of Cx26M34A 分子名称: Gap junction beta-2 protein 著者 Oshima, A, Tani, K, Toloue, M.M, Hiroaki, Y, Smock, A, Inukai, S, Cone, A, Nicholson, B.J, Sosinsky, G.E, Fujiyoshi, Y. 登録日 2010-08-19 公開日 2010-11-03 最終更新日 2024-02-21 実験手法 ELECTRON CRYSTALLOGRAPHY (6 Å) 主引用文献 Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels. J.Mol.Biol., 405, 2011
3IZ2	C-alpha model fitted into the EM structure of Cx26M34Adel2-7 分子名称: Gap junction beta-2 protein 著者 Oshima, A, Tani, K, Toloue, M.M, Hiroaki, Y, Smock, A, Inukai, S, Cone, A, Nicholson, B.J, Sosinsky, G.E, Fujiyoshi, Y. 登録日 2010-08-19 公開日 2010-11-03 最終更新日 2024-02-21 実験手法 ELECTRON CRYSTALLOGRAPHY (10 Å) 主引用文献 Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels. J.Mol.Biol., 405, 2011
5LVS	Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries 分子名称: 8-azanyl-4-(2-hydroxy-2-oxoethyloxy)quinoline-2-carboxylic acid, 8-azanyl-4-(2-methylpropoxy)quinoline-2-carboxylic acid, 8-azanyl-4-(3-azanylpropoxy)quinoline-2-carboxylic acid, ... 著者 Jewginski, M, LANGLOIS D'ESTAINTOT, B, Granier, T, Huc, Y. 登録日 2016-09-14 公開日 2017-03-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Self-Assembled Protein-Aromatic Foldamer Complexes with 2:3 and 2:2:1 Stoichiometries. J. Am. Chem. Soc., 139, 2017
5A2Q	Structure of the HCV IRES bound to the human ribosome 分子名称: 18S RRNA, HCV IRES, MAGNESIUM ION, ... 著者 Quade, N, Leiundgut, M, Boehringer, D, Heuvel, J.v.d, Ban, N. 登録日 2015-05-21 公開日 2015-07-15 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-Em Structure of Hepatitis C Virus Ires Bound to the Human Ribosome at 3.9 Angstrom Resolution Nat.Commun., 6, 2015
5MWZ	Crystal structure of the human BRPF1 bromodomain in complex with BZ073 分子名称: Peregrin, ~{N}-[1,4-diethyl-2,3-bis(oxidanylidene)-7-piperidin-1-yl-quinoxalin-6-yl]-2-(4-methylpiperazin-1-yl)ethanamide 著者 Zhu, J, Caflisch, A. 登録日 2017-01-20 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155, 2018
3J4G	Structure of lysozyme solved by MicroED to 2.9 A 分子名称: Lysozyme C 著者 Shi, D, Nannenga, B.L, Iadanza, M.G, Gonen, T. 登録日 2013-08-12 公開日 2013-11-13 最終更新日 2015-04-15 実験手法 ELECTRON CRYSTALLOGRAPHY (2.901 Å) 主引用文献 Three-dimensional electron crystallography of protein microcrystals. Elife, 2, 2013
6VTL	Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a resting state at high pH 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1 著者 Yoder, N, Gouaux, E. 登録日 2020-02-12 公開日 2020-03-11 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.65 Å) 主引用文献 The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity. Elife, 9, 2020
6UGG	Structure of unmodified E. coli tRNA(Asp) 分子名称: tRNAasp 著者 Chan, C.W, Mondragon, A. 登録日 2019-09-26 公開日 2020-01-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of unbound tRNAs. Rna, 26, 2020
3J68	Structural mechanism of the dynein powerstroke (pre-powerstroke state) 分子名称: Dynein motor domain 著者 Lin, J, Okada, K, Raytchev, M, Smith, M.C, Nicastro, D. 登録日 2013-12-23 公開日 2014-04-23 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (30 Å) 主引用文献 Structural mechanism of the dynein power stroke. Nat.Cell Biol., 16, 2014

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