8FGR

Structure of human endothelial nitric oxide synthase heme domain in complex with 6-(5-(2-aminoethyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine

Summary for 8FGR

Entry DOI	10.2210/pdb8fgr/pdb
Descriptor	Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (10 entities in total)
Functional Keywords	nitric oxide synthase inhibitor, heme enzyme, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	206011.49
Authors	Li, H.,Poulos, T.L. (deposition date: 2022-12-12, release date: 2023-10-11)
Primary citation	Vasu, D.,Do, H.T.,Li, H.,Hardy, C.D.,Awasthi, A.,Poulos, T.L.,Silverman, R.B. Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66:9934-9953, 2023 Cited by PubMed: 37433128 DOI: 10.1021/acs.jmedchem.3c00782 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation