5AFX
| T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1238 | 分子名称: | FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, [1-hydroxy-2-(1-nonyl-1H-3lambda~5~-imidazol-3-yl)ethane-1,1-diyl]bis(phosphonic acid) | 著者 | Yang, G, Oldfield, E, No, J.H. | 登録日 | 2015-01-27 | 公開日 | 2015-10-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59, 2015
|
|
8XSX
| Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2 | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Li, X, Wang, M, Cheng, J. | 登録日 | 2024-01-10 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
|
|
2OPM
| Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461 | 分子名称: | 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM, Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)], MAGNESIUM ION, ... | 著者 | Cao, R, Gao, Y.G, Robinson, H, Goddard, A. | 登録日 | 2007-01-29 | 公開日 | 2007-12-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc., 131, 2009
|
|
7O71
| Cryo-EM structure of a respiratory complex I | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Acyl carrier protein ACPM1 of NADH:Ubiquinone Oxidoreductase (Complex I), ... | 著者 | Parey, K, Vonck, J. | 登録日 | 2021-04-12 | 公開日 | 2021-11-10 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. Sci Adv, 7, 2021
|
|
8I1B
| |
9FBV
| |
7T79
| |
7T78
| |
3N3D
| Crystal structure of geranylgeranyl pyrophosphate synthase from lactobacillus brevis atcc 367 | 分子名称: | Geranylgeranyl pyrophosphate synthase, SULFATE ION | 著者 | Patskovsky, Y, Toro, R, Rutter, M, Chang, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York Structural GenomiX Research Consortium (NYSGXRC), New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2010-05-19 | 公開日 | 2010-06-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of Geranylgeranyl Pyrophosphate Synthase from Lactobacillus Brevis To be Published
|
|
7ZW0
| FAP-80S Complex - Rotated state | 分子名称: | 18S ribosomal RNA (RDN18-1), 25S ribosomal RNA (RDN25-1), 40S ribosomal protein S0-A, ... | 著者 | Ikeuchi, K, Buschauer, R, Berninghausen, O, Becker, T, Beckmann, R. | 登録日 | 2022-05-17 | 公開日 | 2022-10-05 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover. Mol.Cell, 82, 2022
|
|
6R0I
| Glycogen Phosphorylase b in complex with 4 | 分子名称: | Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Koulas, M.S, Tsagkarakou, S.A, Kyriakis, E, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D. | 登録日 | 2019-03-13 | 公開日 | 2019-04-17 | 最終更新日 | 2019-04-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-beta-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors. Molecules, 24, 2019
|
|
8HTZ
| E. coli 70S ribosome complexed with H. marismortui tRNA_Ile2 bearing agm2C34 in classical state | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Akiyama, N, Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | 登録日 | 2022-12-22 | 公開日 | 2024-04-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine. Nat.Struct.Mol.Biol., 31, 2024
|
|
1BJ1
| VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY | 分子名称: | Fab fragment, heavy chain, light chain, ... | 著者 | Muller, Y.A, Christinger, H.W, De Vos, A.M. | 登録日 | 1998-06-30 | 公開日 | 1999-01-13 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface. Structure, 6, 1998
|
|
1UBY
| STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE | 分子名称: | DIMETHYLALLYL DIPHOSPHATE, FARNESYL DIPHOSPHATE SYNTHASE, MAGNESIUM ION | 著者 | Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C. | 登録日 | 1996-10-14 | 公開日 | 1997-03-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Regulation of product chain length by isoprenyl diphosphate synthases. Proc.Natl.Acad.Sci.USA, 93, 1996
|
|
1YHQ
| Crystal Structure Of Azithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui | 分子名称: | 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ... | 著者 | Tu, D, Blaha, G, Moore, P.B, Steitz, T.A. | 登録日 | 2005-01-10 | 公開日 | 2005-04-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell(Cambridge,Mass.), 121, 2005
|
|
8A6Z
| PcIDS1 in complex with Mn2+ and IPP | 分子名称: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, GLYCEROL, Isoprenyl diphosphate synthase, ... | 著者 | Ecker, F, Boland, W, Groll, M. | 登録日 | 2022-06-20 | 公開日 | 2023-05-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Metal-dependent enzyme symmetry guides the biosynthetic flux of terpene precursors. Nat.Chem., 15, 2023
|
|
7P7Q
| E. faecalis 70S ribosome bound by PoxtA-EQ2, high-resolution combined volume | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Crowe-McAuliffe, C, Wilson, D.N. | 登録日 | 2021-07-20 | 公開日 | 2022-02-23 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics. Nat Commun, 13, 2022
|
|
7TOP
| Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein PR20 | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
|
|
1CZ8
| VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY | 分子名称: | HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ... | 著者 | Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B. | 登録日 | 1999-09-01 | 公開日 | 2000-03-20 | 最終更新日 | 2017-04-05 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J.Mol.Biol., 293, 1999
|
|
7VYN
| Matrix arm of active state CI from Q1-NADH dataset | 分子名称: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | 著者 | Gu, J, Yang, M. | 登録日 | 2021-11-14 | 公開日 | 2022-12-28 | 最終更新日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | The coupling mechanism of mammalian mitochondrial complex I. Nat.Struct.Mol.Biol., 29, 2022
|
|
1VQ9
| |
7P7C
| Complex I from E. coli, DDM/LMNG-purified, Apo, Open state | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CALCIUM ION, EICOSANE, ... | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | 登録日 | 2021-07-19 | 公開日 | 2022-09-21 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
7OW7
| |
3CC2
| |
7OYB
| Cryo-EM structure of the 6 hpf zebrafish embryo 80S ribosome | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | 著者 | Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A. | 登録日 | 2021-06-24 | 公開日 | 2022-07-13 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | A molecular network of conserved factors keeps ribosomes dormant in the egg. Nature, 613, 2023
|
|