5KW1
 
 | | Crystal Structure of the Two Tandem RRM Domains of PUF60 Bound to a Modified AdML Pre-mRNA 3' Splice Site Analogue | | 分子名称: | CHLORIDE ION, DNA/RNA (30-MER), Poly(U)-binding-splicing factor PUF60 | | 著者 | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | | 登録日 | 2016-07-15 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.
Plos One, 15, 2020
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7NMI
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2JT4
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5KVY
 | | CRYSTAL STRUCTURE OF THE TWO TANDEM RRM DOMAINS OF PUF60 BOUND TO A PORTION OF AN ADML PRE-MRNA 3' SPLICE SITE ANALOG | | 分子名称: | CHLORIDE ION, DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | | 著者 | Hsiao, H.-H, Crichlow, G.V, Albright, R.A, Murphy, J.W, Lolis, E.J, Braddock, D.T. | | 登録日 | 2016-07-15 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.
Plos One, 15, 2020
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7BGF
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2IX7
 | | Structure of apo-calmodulin bound to unconventional myosin V | | 分子名称: | CALMODULIN, CYSTEINE, MYOSIN-5A, ... | | 著者 | Houdusse, A, Gaucher, J.F, Mui, S, Krementsova, E, Trybus, K.M, Cohen, C. | | 登録日 | 2006-07-07 | | 公開日 | 2006-12-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of Apo-Calmodulin Bound to the First Two Iq Motifs of Myosin V Reveals Essential Recognition Features.
Proc.Natl.Acad.Sci.USA, 103, 2006
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5OTE
 | | MRCK beta in complex with BDP-00008900 | | 分子名称: | 1,2-ETHANEDIOL, 2-[4-[(6~{S})-1,8-diazaspiro[5.5]undecan-8-yl]-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-1,3-thiazole, CHLORIDE ION, ... | | 著者 | Schuettelkopf, A.W. | | 登録日 | 2017-08-21 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Cancer Res., 78, 2018
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2K4P
 | | Solution Structure of Ship2-Sam | | 分子名称: | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 | | 著者 | Leone, M, Pellecchia, M. | | 登録日 | 2008-06-16 | | 公開日 | 2008-11-25 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR Studies of a Heterotypic Sam-Sam Domain Association: The Interaction between the Lipid Phosphatase Ship2 and the EphA2 Receptor.
Biochemistry, 47, 2008
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7D4I
 | | Cryo-EM structure of 90S small ribosomal precursors complex with the DEAH-box RNA helicase Dhr1 (State F) | | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S1-A, ... | | 著者 | Du, Y, Zhang, J, An, W, Ye, K. | | 登録日 | 2020-09-24 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structure of 90S small ribosomal precursors complex with Dhr1
To Be Published
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2KC1
 | | NMR structure of the F0 domain (residues 0-85) of the talin ferm domain | | 分子名称: | MKIAA1027 protein | | 著者 | Goult, B.T, Elliott, P.R, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | | 登録日 | 2008-12-13 | | 公開日 | 2010-01-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Embo J., 29, 2010
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7D63
 | | Cryo-EM structure of 90S preribosome with inactive Utp24 (state C) | | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S1-A, ... | | 著者 | Du, Y, Zhang, J, An, W, Ye, K. | | 登録日 | 2020-09-29 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (12.3 Å) | | 主引用文献 | Cryo-EM structure of 90S preribosome with inactive Utp24 (state C)
To Be Published
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7D5T
 | | Cryo-EM structure of 90S preribosome with inactive Utp24 (state F1) | | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S1-A, ... | | 著者 | Du, Y, Zhang, J, An, W, Ye, K. | | 登録日 | 2020-09-28 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (6 Å) | | 主引用文献 | Cryo-EM structure of 90S preribosome with inactive Utp24 (state F1)
To Be Published
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2KSO
 | | EphA2:SHIP2 SAM:SAM complex | | 分子名称: | Ephrin type-A receptor 2, Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 | | 著者 | Hota, P.K, Preeti, C, Stetzik, L, Kim, S, Wang, B, Lee, H, Buck, M. | | 登録日 | 2010-01-10 | | 公開日 | 2011-07-27 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and function of the EphA2:SHIP2 SAM domain heterodimer
To be Published
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6ZQE
 | | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-A (Poly-Ala) | | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S1-A, ... | | 著者 | Cheng, J, Lau, B, Venuta, G.L, Berninghausen, O, Hurt, E, Beckmann, R. | | 登録日 | 2020-07-09 | | 公開日 | 2020-09-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | | 主引用文献 | 90 S pre-ribosome transformation into the primordial 40 S subunit.
Science, 369, 2020
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6ZQD
 | | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Post-A1 | | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S1-A, ... | | 著者 | Cheng, J, Lau, B, Venuta, G.L, Berninghausen, O, Hurt, E, Beckmann, R. | | 登録日 | 2020-07-09 | | 公開日 | 2020-09-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | 90 S pre-ribosome transformation into the primordial 40 S subunit.
Science, 369, 2020
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6ZQF
 | | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-B (Poly-Ala) | | 分子名称: | 18S rRNA, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ... | | 著者 | Cheng, J, Lau, B, Venuta, G.L, Berninghausen, O, Hurt, E, Beckmann, R. | | 登録日 | 2020-07-09 | | 公開日 | 2020-09-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | 90 S pre-ribosome transformation into the primordial 40 S subunit.
Science, 369, 2020
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2C9O
 | | 3D Structure of the human RuvB-like helicase RuvBL1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RUVB-LIKE 1 | | 著者 | Matias, P.M, Gorynia, S, Donner, P, Carrondo, M.A. | | 登録日 | 2005-12-14 | | 公開日 | 2006-10-23 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of the human AAA+ protein RuvBL1.
J. Biol. Chem., 281, 2006
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2JUP
 | | FBP28WW2 domain in complex with the PPLIPPPP peptide | | 分子名称: | Formin-1, Transcription elongation regulator 1 | | 著者 | Ramirez-Espain, X, Ruiz, L, Martin-Malpartida, P, Oschkinat, H, Macias, M.J. | | 登録日 | 2007-09-01 | | 公開日 | 2007-11-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Characterization of a New Binding Motif and a Novel Binding Mode in Group 2 WW Domains
J.Mol.Biol., 373, 2007
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7NVY
 | | RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position | | 分子名称: | CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | 著者 | Aibara, S, Schilbach, S, Cramer, P. | | 登録日 | 2021-03-16 | | 公開日 | 2021-05-05 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | | 主引用文献 | Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
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7NVX
 | | TFIIH in a post-translocated state (with ADP-BeF3) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, CDK-activating kinase assembly factor MAT1, ... | | 著者 | Aibara, S, Schilbach, S, Cramer, P. | | 登録日 | 2021-03-16 | | 公開日 | 2021-05-05 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
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7NW0
 | | RNA polymerase II pre-initiation complex with open promoter DNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, CDK-activating kinase assembly factor MAT1, ... | | 著者 | Aibara, S, Schilbach, S, Cramer, P. | | 登録日 | 2021-03-16 | | 公開日 | 2021-05-05 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
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7NVW
 | | TFIIH in a pre-translocated state (without ADP-BeF3) | | 分子名称: | CDK-activating kinase assembly factor MAT1, General transcription and DNA repair factor IIH helicase subunit XPB, General transcription factor IIE subunit 1, ... | | 著者 | Aibara, S, Schilbach, S, Cramer, P. | | 登録日 | 2021-03-16 | | 公開日 | 2021-05-05 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
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7NVZ
 | | RNA polymerase II pre-initiation complex with closed promoter DNA in distal position | | 分子名称: | CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | 著者 | Aibara, S, Schilbach, S, Cramer, P. | | 登録日 | 2021-03-16 | | 公開日 | 2021-05-05 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | | 主引用文献 | Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
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2H8H
 | | Src kinase in complex with a quinazoline inhibitor | | 分子名称: | N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Otterbein, L.R, Norman, R, Pauptit, R.A, Rowsell, S, Breed, J. | | 登録日 | 2006-06-07 | | 公開日 | 2006-11-21 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
J.Med.Chem., 49, 2006
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2JV9
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