PDB: 23765 件ウェブページステータス検索Chemie searchBIRD

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4UBV	Structure of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis with an partially acetylated cysteine in complex with acetyl-CoA and CoA 分子名称: 1,4-DIETHYLENE DIOXIDE, ACETYL COENZYME *A, Acetyl-CoA acetyltransferase FadA5, ... 著者 Schaefer, C.M, Kisker, C. 登録日 2014-08-13 公開日 2014-12-17 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis. Structure, 23, 2015
5TVJ	Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with CoA and inhibitor 2k*: 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium 分子名称: 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium, CHLORIDE ION, COENZYME A, ... 著者 Gajadeera, C.S, Garzan, A, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2016-11-09 公開日 2017-03-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors. ACS Infect Dis, 3, 2017
7XAM	Mycobacterium smegmatis 50S ribosomal subunit from Stationary phase of growth 分子名称: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... 著者 Sengupta, J, Baid, P. 登録日 2022-03-18 公開日 2023-05-03 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM captures a unique conformational rearrangement in 23S rRNA helices of the Mycobacterium 50S subunit. Int.J.Biol.Macromol., 253, 2023
4LN9	Crystal structure of the dehydratase domain from the terminal module of the rifamycin polyketide synthase 分子名称: Rifamycin polyketide synthase 著者 Gay, D.C, You, Y.-O, Cane, D, Keatinge-Clay, A.T. 登録日 2013-07-11 公開日 2013-12-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase. Biochemistry, 52, 2013
9F48	KS + AT di-domain of polyketide synthase 13 in Mycobacterium tuberculosis 分子名称: Polyketide synthase Pks13 著者 Johnston, H.E, Futterer, K. 登録日 2024-04-26 公開日 2024-05-22 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-electron microscopy structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis. Microbiology (Reading, Engl.), 170, 2024
7KIF	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 transcription factor 分子名称: DNA (55-MER), DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2020-10-23 公開日 2021-04-21 最終更新日 2025-05-14 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
7KIM	Mycobacterium tuberculosis WT RNAP transcription closed promoter complex with WhiB7 transcription factor 分子名称: DNA (45-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2020-10-23 公開日 2021-04-21 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
7KIN	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 promoter 分子名称: DNA (49-MER), DNA (54-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2020-10-23 公開日 2021-04-21 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (2.74 Å) 主引用文献 Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
6S0U	The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus in complex with nickel and 2-oxoglutarate 分子名称: 2-OXOGLUTARIC ACID, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Mrugala, B, Porebski, P.J, Niedzialkowska, E, Minor, W, Borowski, T. 登録日 2019-06-18 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)-an enzyme with a broad range of substrates. Febs J., 288, 2021
3DWG	Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis 分子名称: 9.5 kDa culture filtrate antigen cfp10A, Cysteine synthase B, PYRIDOXAL-5'-PHOSPHATE 著者 Jurgenson, C.T, Burns, K.E, Begley, T.P, Ealick, S.E. 登録日 2008-07-22 公開日 2008-09-23 最終更新日 2025-03-26 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis. Biochemistry, 47, 2008
6S0T	The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus in complex with nickel, sulfate, soaked with iodide 分子名称: IODIDE ION, Kanamycin B dioxygenase, NICKEL (II) ION, ... 著者 Mrugala, B, Porebski, P.J, Niedzialkowska, E, Cymborowski, M.T, Minor, W, Borowski, T. 登録日 2019-06-18 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)-an enzyme with a broad range of substrates. Febs J., 288, 2021
5ID2	Asymmetry in the active site of Mycobacterium tuberculosis AhpE upon exposure to Mycothiol 分子名称: ACETATE ION, GLYCEROL, Putative peroxiredoxin Rv2238c 著者 Kumar, A, Balakrishna, A.M, Gruber, G. 登録日 2016-02-23 公開日 2016-08-03 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol Free Radic. Biol. Med., 97, 2016
6S0R	The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus complex with nickel, sulfate and chloride 分子名称: CHLORIDE ION, Kanamycin B dioxygenase, NICKEL (II) ION, ... 著者 Mrugala, B, Porebski, P.J, Niedzialkowska, E, Cymborowski, M.T, Minor, W, Borowski, T. 登録日 2019-06-18 公開日 2020-07-08 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)-an enzyme with a broad range of substrates. Febs J., 288, 2021
1LQT	A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase 分子名称: 4-OXO-NICOTINAMIDE-ADENINE DINUCLEOTIDE PHOSPHATE, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Bossi, R.T, Aliverti, A, Raimondi, D, Fischer, F, Zanetti, G, Ferrari, D, Tahallah, N, Maier, C.S, Heck, A.J.R, Rizzi, M, Mattevi, A, TB Structural Genomics Consortium (TBSGC) 登録日 2002-05-13 公開日 2002-07-31 最終更新日 2024-12-25 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase. Biochemistry, 41, 2002
7XKZ	Solution structure of subunit epsilon of the Mycobacterium abscessus F-ATP synthase 分子名称: ATP synthase epsilon chain 著者 Shin, J, Grueber, G, Harikishore, A, Wong, C.F, Prya, R, Dick, T. 登録日 2022-04-20 公開日 2023-03-08 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit epsilon and identification of Ep1MabF1 as a targeted inhibitor. Febs J., 289, 2022
1KNY	KANAMYCIN NUCLEOTIDYLTRANSFERASE 分子名称: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, KANAMYCIN A, KANAMYCIN NUCLEOTIDYLTRANSFERASE, ... 著者 Pedersen, L.C, Benning, M.M, Holden, H.M. 登録日 1995-07-07 公開日 1996-08-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase. Biochemistry, 34, 1995
9HQ7	Partial (52mer) encapsulin shell assembly from Mycobacterium tuberculosis 分子名称: Type 1 encapsulin shell protein 著者 Lewis, C.J, Berger, C, Ravelli, R.B.G. 登録日 2024-12-16 公開日 2025-02-05 最終更新日 2025-02-26 実験手法 ELECTRON MICROSCOPY (4.51 Å) 主引用文献 In situ and in vitro cryo-EM reveal structures of mycobacterial encapsulin assembly intermediates. Commun Biol, 8, 2025
9HQC	Partial (54mer) encapsulin shell assembly from Mycobacterium tuberculosis 分子名称: Type 1 encapsulin shell protein 著者 Lewis, C.J, Berger, C, Ravelli, R.B.G. 登録日 2024-12-16 公開日 2025-02-05 最終更新日 2025-02-26 実験手法 ELECTRON MICROSCOPY (4.57 Å) 主引用文献 In situ and in vitro cryo-EM reveal structures of mycobacterial encapsulin assembly intermediates. Commun Biol, 8, 2025
9GOT	Partial (48mer) encapsulin shell assembly from Mycobacterium tuberculosis 分子名称: Type 1 encapsulin shell protein 著者 Lewis, C.J, Berger, C, Ravelli, R.B.G. 登録日 2024-09-06 公開日 2025-02-05 最終更新日 2025-02-26 実験手法 ELECTRON MICROSCOPY (5.42 Å) 主引用文献 In situ and in vitro cryo-EM reveal structures of mycobacterial encapsulin assembly intermediates. Commun Biol, 8, 2025
9BIN	BRD-8000.3 bound EFPA transporter of Mycobacterium tuberculosis 分子名称: (1S,3S)-N-[6-bromo-5-(pyrimidin-2-yl)pyridin-2-yl]-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxamide, CHOLESTEROL HEMISUCCINATE, Uncharacterized MFS-type transporter EfpA, ... 著者 Khandelwal, N.K, Gupta, M, Stroud, R.M. 登録日 2024-04-23 公開日 2025-02-05 最終更新日 2025-06-04 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Inhibitor BRD-8000.3 bound EfpA transporter of Mycobacterium tuberculosis To Be Published
9BIQ	BRD-9327 bound EFPA transporter of Mycobacterium tuberculosis 分子名称: CHOLESTEROL HEMISUCCINATE, N-(7-benzoyl-2,3-dihydro-1,4-benzodioxin-6-yl)-2-bromobenzamide, Uncharacterized MFS-type transporter EfpA, ... 著者 Khandelwal, N.K, Gupta, M, Stroud, R.M. 登録日 2024-04-24 公開日 2025-02-05 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 BRD-8000.3 bound EFPA transporter of Mycobacterium tuberculosis To Be Published
8IBO	Crystal structure of Wild-Type Mycobacterium tuberculosis ClpC1 N-terminal domain in complex with Lassomycin 分子名称: ACETATE ION, Lassomycin, Negative regulator of genetic competence ClpC/mecB 著者 Jagdev, M.K, Vasudevan, D. 登録日 2023-02-10 公開日 2023-09-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Crystal structure of the N-terminal domain of MtClpC1 in complex with the anti-mycobacterial natural peptide Lassomycin. Int.J.Biol.Macromol., 253, 2023
8IBP	Crystal structure of Mycobacterium tuberculosis R21K ClpC1 N-terminal domain in complex with Lassomycin 分子名称: ACETATE ION, Lassomycin, Negative regulator of genetic competence ClpC/mecB 著者 Jagdev, M.K, Vasudevan, D. 登録日 2023-02-10 公開日 2023-09-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal structure of the N-terminal domain of MtClpC1 in complex with the anti-mycobacterial natural peptide Lassomycin. Int.J.Biol.Macromol., 253, 2023
3D98	Crystal structure of GlmU from Mycobacterium tuberculosis, ligand-free form 分子名称: Bifunctional protein glmU 著者 Zhang, Z, Squire, C.J, Baker, E.N. 登録日 2008-05-27 公開日 2009-03-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure and function of GlmU from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.D, 65, 2009
3D8V	Crystal structure of GlmU from Mycobacterium tuberculosis in complex with uridine-diphosphate-N-acetylglucosamine 分子名称: Bifunctional protein glmU, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE 著者 Zhang, Z, Squire, C.J, Baker, E.N. 登録日 2008-05-25 公開日 2009-03-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structure and function of GlmU from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.D, 65, 2009

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