4RW4
| Crystal Structure of HIV-1 Reverse Transcriptase (K103N,Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor | 分子名称: | (2E)-3-(3-chloro-5-{4-chloro-2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, Reverse transcriptase/ribonuclease H, p51 subunit, ... | 著者 | Frey, K.M, Anderson, K.S. | 登録日 | 2014-12-01 | 公開日 | 2015-04-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.674 Å) | 主引用文献 | Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants. J.Med.Chem., 58, 2015
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4RW8
| Crystal Structure of HIV-1 Reverse Transcriptase in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor' | 分子名称: | (2E)-3-(3-chloro-5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, Reverse transcriptase/ribonuclease H, p51 subunit, ... | 著者 | Frey, K.M, Anderson, K.S. | 登録日 | 2014-12-01 | 公開日 | 2015-04-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.878 Å) | 主引用文献 | Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants. J.Med.Chem., 58, 2015
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6T90
| OCT4-SOX2-bound nucleosome - SHL-6 | 分子名称: | DNA (146-MER), Green fluorescent protein,POU domain, class 5, ... | 著者 | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | 登録日 | 2019-10-25 | 公開日 | 2020-05-06 | 最終更新日 | 2020-07-08 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
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6KE9
| The Human Telomeric Nucleosome Displays Distinct Structural and Dynamic Properties | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Histone H3.1, ... | 著者 | Soman, A, Liew, C.W, Teo, H.L, Berezhnoy, N, Korolev, N, Rhodes, D, Nordenskiold, L. | 登録日 | 2019-07-04 | 公開日 | 2020-04-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | The human telomeric nucleosome displays distinct structural and dynamic properties. Nucleic Acids Res., 48, 2020
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6JXD
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6K1I
| Human nucleosome core particle with gammaH2A.X variant | 分子名称: | CHLORIDE ION, DNA (147-MER), Histone H2AX, ... | 著者 | Sharma, D, De Falco, L, Davey, C.A. | 登録日 | 2019-05-10 | 公開日 | 2020-01-15 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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6K1K
| Human nucleosome core particle with H2A.X S139E variant | 分子名称: | CHLORIDE ION, DNA (145-MER), Histone H2AX, ... | 著者 | Sharma, D, De Falco, L, Davey, C.A. | 登録日 | 2019-05-10 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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6K1J
| Human nucleosome core particle with H2A.X variant | 分子名称: | CHLORIDE ION, DNA (145-MER), Histone H2AX, ... | 著者 | Sharma, D, De Falco, L, Davey, C.A. | 登録日 | 2019-05-10 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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6LE9
| The Human Telomeric Nucleosome Displays Distinct Structural and Dynamic Properties | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Histone H3.1, ... | 著者 | Soman, A, Liew, C.W, Teo, H.L, Berezhnoy, N, Korolev, N, Rhodes, D, Nordenskiold, L. | 登録日 | 2019-11-24 | 公開日 | 2020-04-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The human telomeric nucleosome displays distinct structural and dynamic properties. Nucleic Acids Res., 48, 2020
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6L9H
| The Human Telomeric Nucleosome Displays Distinct Structural and Dynamic Properties | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Histone H3.1, ... | 著者 | Soman, A, Liew, C.W, Teo, H.L, Berezhnoy, N, Korolev, N, Rhodes, D, Nordenskiold, L. | 登録日 | 2019-11-10 | 公開日 | 2020-04-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The human telomeric nucleosome displays distinct structural and dynamic properties. Nucleic Acids Res., 48, 2020
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7UND
| Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | 著者 | Filipovski, M, Vos, S.M, Farnung, L. | 登録日 | 2022-04-10 | 公開日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of nucleosome retention during transcription elongation. Science, 376, 2022
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1YRY
| Crystal structure of human PNP complexed with MESG | 分子名称: | 7-METHYL-6-THIO-GUANOSINE, Purine nucleoside phosphorylase, SULFATE ION | 著者 | Silva, R.G, Pereira, J.H, Canduri, F, Basso, L.A, de Azevedo Jr, W.F, Santos, D.S. | 登録日 | 2005-02-05 | 公開日 | 2006-01-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine Arch.Biochem.Biophys., 442, 2005
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4R5P
| Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor | 分子名称: | 5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3', 5'-D(*TP*GP*GP*AP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3', HIV-1 reverse transcriptase, ... | 著者 | Das, K, Martinez, S.E, Arnold, E. | 登録日 | 2014-08-21 | 公開日 | 2015-03-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | 主引用文献 | Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics. Proc.Natl.Acad.Sci.USA, 112, 2015
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3MJR
| Human dCK complex with Acyclic Nucleoside | 分子名称: | 9-HYROXYETHOXYMETHYLGUANINE, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | 著者 | Hazra, S, Lavie, A. | 登録日 | 2010-04-13 | 公開日 | 2010-07-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues. J.Med.Chem., 53, 2010
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3MGR
| Binding of Rubidium ions to the Nucleosome Core Particle | 分子名称: | CHLORIDE ION, DNA (147-MER), Histone H2A, ... | 著者 | Mohideen, K, Muhammad, R, Davey, C.A. | 登録日 | 2010-04-07 | 公開日 | 2010-06-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Perturbations in nucleosome structure from heavy metal association. Nucleic Acids Res., 38, 2010
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3DDI
| Crystal structure of the mimivirus NDK +Kpn-N62L-R107G triple mutant complexed with TDP | 分子名称: | MAGNESIUM ION, Nucleoside diphosphate kinase, THYMIDINE-5'-DIPHOSPHATE | 著者 | Jeudy, S, Lartigue, A, Claverie, J.M, Abergel, A. | 登録日 | 2008-06-05 | 公開日 | 2009-06-16 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Dissecting the unique nucleotide specificity of mimivirus nucleoside diphosphate kinase. J.Virol., 83, 2009
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6K2Q
| Aeromonas hydrophila MtaN-2 complexed with adenine | 分子名称: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE | 著者 | Chen, J, Liu, W, Wang, L, Shang, F, Lan, J, Chen, Y, Xu, Y. | 登録日 | 2019-05-15 | 公開日 | 2019-05-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of Aeromonas hydrophila Cytoplasmic 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase. Biochemistry, 58, 2019
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3MGP
| Binding of Cobalt ions to the Nucleosome Core Particle | 分子名称: | CHLORIDE ION, COBALT (II) ION, DNA (147-MER), ... | 著者 | Mohideen, K, Muhammad, R, Davey, C.A. | 登録日 | 2010-04-07 | 公開日 | 2010-06-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Perturbations in nucleosome structure from heavy metal association. Nucleic Acids Res., 38, 2010
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1ZS6
| structure of human nucleoside-diphosphate kinase 3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase 3 | 著者 | Choe, J, Dimov, S, Arrowsmith, C, Edwards, A, Sundstrom, M, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2005-05-23 | 公開日 | 2005-06-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of human nucleoside-diphosphate kinase 3 To be Published
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7UNC
| Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | 著者 | Filipovski, M, Vos, S.M, Farnung, L. | 登録日 | 2022-04-10 | 公開日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of nucleosome retention during transcription elongation. Science, 376, 2022
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8GXS
| PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X. | 登録日 | 2022-09-21 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | 主引用文献 | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
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8GXQ
| PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y. | 登録日 | 2022-09-21 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (5.04 Å) | 主引用文献 | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
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6GEN
| Chromatin remodeller-nucleosome complex at 4.5 A resolution. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP6, BERYLLIUM TRIFLUORIDE ION, ... | 著者 | Willhoft, O, Chua, E.Y.D, Wilkinson, M, Wigley, D.B. | 登録日 | 2018-04-27 | 公開日 | 2018-10-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure and dynamics of the yeast SWR1-nucleosome complex. Science, 362, 2018
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6GEJ
| Chromatin remodeller-nucleosome complex at 3.6 A resolution. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP6, BERYLLIUM TRIFLUORIDE ION, ... | 著者 | Willhoft, O, Chua, E.Y.D, Wilkinson, M, Wigley, D.B. | 登録日 | 2018-04-26 | 公開日 | 2018-10-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure and dynamics of the yeast SWR1-nucleosome complex. Science, 362, 2018
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1PAE
| nucleoside diphosphate kinase | 分子名称: | Nucleoside diphosphate kinase, cytosolic, SELENIUM ATOM | 著者 | Strub, M.-P, Hoh, F, Sanchez, J.-F, Strub, J.M, Bock, A, Aumelas, A, Dumas, C. | 登録日 | 2003-05-14 | 公開日 | 2003-11-11 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Selenomethionine and Selenocysteine Double Labeling Strategy for Crystallographic Phasing Structure, 11, 2003
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