PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

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3LNI	Crystal structure of E-cadherin EC12 E89A 分子名称: CALCIUM ION, Cadherin-1 著者 Harrison, O, Jin, X, Shapiro, L. 登録日 2010-02-02 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Two-step adhesive binding by classical cadherins. Nat.Struct.Mol.Biol., 17, 2010
3LQD	Crystal structure determination of Lepus europaeus 2.8 A resolution 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, OXYGEN MOLECULE, ... 著者 Thenmozhi, M, Sathya Moothy, Pon, Balasubramanian, M, Ponnuswamy, M.N. 登録日 2010-02-09 公開日 2011-02-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure determination of Lepus europaeus 2.8 A resolution To be published
6PVX	RNase A in complex with p5U 分子名称: 5'-O-[(R)-hydroxy{[(S)-hydroxy{[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]oxy}phosphoryl]uridine, Ribonuclease pancreatic 著者 Windsor, I.W, Sheppard, S.M, Cummins, C.C, Raines, R.T. 登録日 2019-07-21 公開日 2019-11-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Nucleoside Tetra- and Pentaphosphates Prepared Using a Tetraphosphorylation Reagent Are Potent Inhibitors of Ribonuclease A. J.Am.Chem.Soc., 141, 2019
3LPK	Structure of BACE Bound to SCH747123 分子名称: Beta-secretase 1, L(+)-TARTARIC ACID, N-[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-{(2R)-4-[(3-methylphenyl)sulfonyl]piperazin-2-yl}ethyl]-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide 著者 Strickland, C, Cumming, J. 登録日 2010-02-05 公開日 2010-04-14 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20, 2010
3LPY	Crystal structure of the RRM domain of CyP33 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Peptidyl-prolyl cis-trans isomerase E, SULFATE ION 著者 Wang, Z, Patel, D.J. 登録日 2010-02-07 公開日 2010-07-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
8UKZ	Structure of P450Blt from Micromonospora sp. MW-13 with E238A Mutation 分子名称: ACETATE ION, Cytochrome P450-SU1, DI(HYDROXYETHYL)ETHER, ... 著者 Hansen, M.H, Cryle, M.J. 登録日 2023-10-15 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis Acs Catalysis, 2024
6PT3	Crystal structure of the active delta opioid receptor in complex with the small molecule agonist DPI-287 分子名称: 4-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl](3-hydroxyphenyl)methyl]-N,N-diethylbenzamide, Delta opioid receptor 著者 Claff, T, Yu, J, Blais, V, Patel, N, Martin, C, Wu, L, Han, G.W, Holleran, B.J, Van der Poorten, O, Hanson, M.A, Sarret, P, Gendron, L, Cherezov, V, Katritch, V, Ballet, S, Liu, Z, Muller, C.E, Stevens, R.C. 登録日 2019-07-14 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Elucidating the active delta-opioid receptor crystal structure with peptide and small-molecule agonists. Sci Adv, 5, 2019
3LC4	Human Cytochrome P450 2E1 in Complex with Omega-Imidazolyl-Dodecanoic Acid 分子名称: 12-(1H-imidazol-1-yl)dodecanoic acid, Cytochrome P450 2E1, PROTOPORPHYRIN IX CONTAINING FE 著者 Scott, E.E, Porubsky, P.R. 登録日 2010-01-09 公開日 2010-05-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Human cytochrome P450 2E1 structures with fatty acid analogs reveal a previously unobserved binding mode. J.Biol.Chem., 285, 2010
6PVV	RNase A in complex with p5A 分子名称: ADENOSINE-5'-PENTAPHOSPHATE, Ribonuclease pancreatic 著者 Windsor, I.W, Sheppard, S.M, Cummins, C.C, Raines, R.T. 登録日 2019-07-21 公開日 2019-11-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Nucleoside Tetra- and Pentaphosphates Prepared Using a Tetraphosphorylation Reagent Are Potent Inhibitors of Ribonuclease A. J.Am.Chem.Soc., 141, 2019
3LDJ	Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding 分子名称: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, Pancreatic trypsin inhibitor 著者 Yang, I.S, Kim, T.G, Park, B.S, Kim, K.H. 登録日 2010-01-13 公開日 2010-09-15 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding. Biochem.Biophys.Res.Commun., 2010
3LDP	Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with small molecule inhibitor 分子名称: 78 kDa glucose-regulated protein, 8-[(quinolin-2-ylmethyl)amino]adenosine 著者 Dokurno, P, Surgenor, A.E, Shaw, T, Macias, A.T, Massey, A.J, Williamson, D.S. 登録日 2010-01-13 公開日 2011-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity. J.Med.Chem., 54, 2011
3L9N	crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27 分子名称: (2S)-N~1~-[5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)propane-1,2-diamine, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Huang, X. 登録日 2010-01-05 公開日 2011-01-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorg.Med.Chem.Lett., 20, 2010
6PXN	Human Casein Kinase 1 delta Tau mutant (R178C) 分子名称: Casein kinase I isoform delta, SULFATE ION 著者 Philpott, J.M, Tripathi, S.M, Partch, C.L. 登録日 2019-07-26 公開日 2020-02-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.551 Å) 主引用文献 Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch. Elife, 9, 2020
6PYB	Sex Hormone-binding globulin mutant E176K in complex with DVT 分子名称: 4,4'-[(3R,4R)-oxolane-3,4-diylbis(methylene)]bis(2-methoxyphenol), CALCIUM ION, Sex hormone-binding globulin 著者 Round, P.W, Das, S, Van Petegem, F. 登録日 2019-07-29 公開日 2019-12-25 最終更新日 2020-02-12 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity. J.Biol.Chem., 295, 2020
4YLG	Structure of an ADP ribosylation factor from Entamoeba histolytica HM-1:IMSS bound to Mg-GDP 分子名称: ADP-ribosylation factor, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2015-03-05 公開日 2015-05-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg(2+)-GDP. Acta Crystallogr.,Sect.F, 71, 2015
3LD6	Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole 分子名称: 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Lanosterol 14-alpha demethylase, ... 著者 Strushkevich, N, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) 登録日 2010-01-12 公開日 2010-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis of human CYP51 inhibition by antifungal azoles. J.Mol.Biol., 397, 2010
4YMD	CL-K1 trimer bound to man(alpha1-2)man 分子名称: CALCIUM ION, Collectin-11, GLYCEROL, ... 著者 Wallis, R, Venkatraman Girija, U, Gingras, A.R, Moody, P.C.E, Marshall, J.E. 登録日 2015-03-06 公開日 2015-04-08 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.87 Å) 主引用文献 Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome. Bmc Biol., 13, 2015
6PZY	CryoEM derived model of NA-73 Fab in complex with N9 Shanghai2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NA-73 fragment antibody heavy chain, ... 著者 Ward, A.B, Turner, H.L, Zhu, X. 登録日 2019-08-01 公開日 2019-12-04 最終更新日 2023-04-05 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe, 26, 2019
4YNO	Crystal structure of MAPK13 at INACTIVE FORM 分子名称: Mitogen-activated protein kinase 13 著者 Miller, C.A, Brett, T.J. 登録日 2015-03-10 公開日 2015-04-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. J.Clin.Invest., 122, 2012
6Q4A	CDK2 in complex with FragLite14 分子名称: 5-iodanylpyrimidine, CYCLIN-DEPENDENT KINASE 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q4I	CDK2 in complex with FragLite35 分子名称: 2-[4-[(2-oxidanylidene-3~{H}-pyridin-4-yl)oxy]phenyl]ethanoic acid, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.11 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
3LFF	Human p38 MAP Kinase in Complex with RL166 分子名称: (4-{3-tert-butyl-5-[(1,3-thiazol-2-ylcarbamoyl)amino]-1H-pyrazol-1-yl}phenyl)acetic acid, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. 登録日 2010-01-16 公開日 2011-04-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha To be Published
6Q21	MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Kim, S.-H. 登録日 1992-07-27 公開日 1992-07-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science, 247, 1990
4YBU	Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding ProteinII in complex with Retinal after 24 h incubation and 1 hour UV irradiation at 1.92 angstrom - 1st cycle 分子名称: Cellular retinoic acid-binding protein 2, RETINAL 著者 Nosrati, M, Geiger, J.H. 登録日 2015-02-19 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.924 Å) 主引用文献 A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution. J.Am.Chem.Soc., 138, 2016
6Q2A	Trypanosoma brucei CLK1 kinase domain in complex with a covalent aminobenzimidazole inhibitor AB1 分子名称: Protein kinase, putative, SULFATE ION, ... 著者 Ma, X, Ornelas, E. 登録日 2019-08-07 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nat Microbiol, 5, 2020

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