3Q6M
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![BU of 3q6m by Molmil](/molmil-images/mine/3q6m) | Crystal Structure of Human MC-HSP90 in C2221 Space Group | 分子名称: | Heat shock protein HSP 90-alpha, SULFATE ION | 著者 | Lee, C.C, Lin, T.W, Ko, T.P, Wang, A.H.-J. | 登録日 | 2011-01-03 | 公開日 | 2011-06-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The hexameric structures of human heat shock protein 90 Plos One, 6, 2011
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9EPL
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![BU of 9epl by Molmil](/molmil-images/mine/9epl) | Mpro from SARS-CoV-2 with 298Q mutation | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Non-structural protein 11, ... | 著者 | Plewka, J, Lis, K, Czarna, A, Pyrc, K, Kantyka, T, Chykunova, Y. | 登録日 | 2024-03-18 | 公開日 | 2024-04-17 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | SARS-CoV-2 M pro oligomerization as a potential target for therapy. Int.J.Biol.Macromol., 267, 2024
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8VE4
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![BU of 8ve4 by Molmil](/molmil-images/mine/8ve4) | Unliganded human transthyretin in the frayed conformation | 分子名称: | Transthyretin | 著者 | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | 登録日 | 2023-12-18 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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8TZ3
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8UP3
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![BU of 8up3 by Molmil](/molmil-images/mine/8up3) | Structure of atypical asparaginase from Rhodospirillum rubrum (mutant Y21F) | 分子名称: | 1,2-ETHANEDIOL, ASPARTIC ACID, Asparaginase, ... | 著者 | Lubkowski, J, Wlodawer, A, Zhang, D. | 登録日 | 2023-10-20 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
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8TOR
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![BU of 8tor by Molmil](/molmil-images/mine/8tor) | ACE2-peptide 2 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Christie, M, Payne, R.J. | 登録日 | 2023-08-03 | 公開日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of High Affinity Cyclic Peptide Ligands for Human ACE2 with SARS-CoV-2 Entry Inhibitory Activity. Acs Chem.Biol., 19, 2024
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8VXY
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![BU of 8vxy by Molmil](/molmil-images/mine/8vxy) | Structure of HamA(E138A,K140A)B-plasmid DNA complex from the Escherichia coli Hachiman defense system | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, HamA, HamB, ... | 著者 | Tuck, O.T, Hu, J.J, Doudna, J.A. | 登録日 | 2024-02-06 | 公開日 | 2024-03-13 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Hachiman is a genome integrity sensor. Biorxiv, 2024
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8VEO
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![BU of 8veo by Molmil](/molmil-images/mine/8veo) | Crystal structure of PRMT5:MEP50 in complex with MTA | 分子名称: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Whittington, D.A. | 登録日 | 2023-12-20 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers. J.Med.Chem., 67, 2024
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8VX9
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8TU9
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![BU of 8tu9 by Molmil](/molmil-images/mine/8tu9) | Cryo-EM structure of HGSNAT-acetyl-CoA complex at pH 7.5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYL COENZYME *A, Enhanced green fluorescent protein,Heparan-alpha-glucosaminide N-acetyltransferase,Isoform 2 of Heparan-alpha-glucosaminide N-acetyltransferase | 著者 | Navratna, V, Kumar, A, Mosalaganti, S. | 登録日 | 2023-08-15 | 公開日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structure of the human heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT) eLife, 13, 2024
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6S7C
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![BU of 6s7c by Molmil](/molmil-images/mine/6s7c) | Crystal structure of CARM1 in complex with inhibitor UM079 | 分子名称: | 1-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]propyl]guanidine, Histone-arginine methyltransferase CARM1 | 著者 | Gunnell, E.A, Muhsen, U, Dowden, J, Dreveny, I. | 登録日 | 2019-07-04 | 公開日 | 2020-03-04 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477, 2020
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8UPC
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![BU of 8upc by Molmil](/molmil-images/mine/8upc) | Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K158M) | 分子名称: | Asparaginase, CHLORIDE ION, GLYCEROL | 著者 | Lubkowski, J, Wlodawer, A, Zhang, D. | 登録日 | 2023-10-22 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
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6RG6
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![BU of 6rg6 by Molmil](/molmil-images/mine/6rg6) | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complexe with an inhibitor | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[3-(6-azanyl-9~{H}-purin-8-yl)prop-2-ynoxymethyl]oxolane-3,4-diol, CITRIC ACID, NAD kinase 1 | 著者 | Gelin, M, Labesse, G. | 登録日 | 2019-04-16 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | From Substrate to Fragments to Inhibitor ActiveIn VivoagainstStaphylococcus aureus. Acs Infect Dis., 6, 2020
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8VGZ
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6RG7
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![BU of 6rg7 by Molmil](/molmil-images/mine/6rg7) | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complexe with an inhibitor | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-(6-azanyl-9~{H}-purin-8-yl)prop-2-ynyl-methyl-amino]methyl]oxolane-3,4-diol, CITRIC ACID, NAD kinase 1 | 著者 | Gelin, M, Labesse, G. | 登録日 | 2019-04-16 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | From Substrate to Fragments to Inhibitor ActiveIn VivoagainstStaphylococcus aureus. Acs Infect Dis., 6, 2020
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8W43
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8W45
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![BU of 8w45 by Molmil](/molmil-images/mine/8w45) | X-ray crystal structure of V30M-TTR in complex with pinostilbene | 分子名称: | 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol, SODIUM ION, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-08-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
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8ZM2
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![BU of 8zm2 by Molmil](/molmil-images/mine/8zm2) | Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 16 | 分子名称: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, methyl (9~{R})-9-oxidanyl-9-(trifluoromethyl)fluorene-4-carboxylate | 著者 | Akai, S, Orita, T, Nomura, A, Adachi, T. | 登録日 | 2024-05-22 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase. Bioorg.Med.Chem.Lett., 109, 2024
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8XS3
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![BU of 8xs3 by Molmil](/molmil-images/mine/8xs3) | Structure of MPXV B6 and D68 fab complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D68_heavy chain, ... | 著者 | wu, L.L, Sun, J.Q. | 登録日 | 2024-01-08 | 公開日 | 2024-06-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Two noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infections. Nat Commun, 15, 2024
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8VXA
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6RGA
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![BU of 6rga by Molmil](/molmil-images/mine/6rga) | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complexe with an inhibitor | 分子名称: | (2~{R},3~{S},4~{R},5~{R})-2-(aminomethyl)-5-[8-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy]prop-1-ynyl]-6-azanyl-purin-9-yl]oxolane-3,4-diol, CITRIC ACID, NAD kinase 1 | 著者 | Gelin, M, Labesse, G. | 登録日 | 2019-04-16 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | From Substrate to Fragments to Inhibitor ActiveIn VivoagainstStaphylococcus aureus. Acs Infect Dis., 6, 2020
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8W47
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![BU of 8w47 by Molmil](/molmil-images/mine/8w47) | X-ray crystal structure of V30M-TTR in complex with isorhapontigenin | 分子名称: | 5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol, SODIUM ION, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-08-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
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8UYF
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![BU of 8uyf by Molmil](/molmil-images/mine/8uyf) | Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer | 分子名称: | Serine/threonine-protein kinase Pink1, mitochondrial | 著者 | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | 登録日 | 2023-11-13 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
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6RGB
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![BU of 6rgb by Molmil](/molmil-images/mine/6rgb) | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complexe with an inhibitor | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]prop-2-ynylamino]methyl]oxolane-3,4-diol, CITRIC ACID, NAD kinase 1 | 著者 | Gelin, M, Labesse, G. | 登録日 | 2019-04-16 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | From Substrate to Fragments to Inhibitor ActiveIn VivoagainstStaphylococcus aureus. Acs Infect Dis., 6, 2020
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8V9A
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![BU of 8v9a by Molmil](/molmil-images/mine/8v9a) | GII.NA1 Loreto 1257 norovirus protruding domain | 分子名称: | 1,2-ETHANEDIOL, Capsid protein VP1 | 著者 | Kher, G, Kim, I, Pancera, M, Hansman, G. | 登録日 | 2023-12-07 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses. J.Virol., 2024
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