PDB: 45118 件ウェブページステータス検索Chemie searchBIRD

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3WHA	Hsp90 alpha N-terminal domain in complex with a tricyclic inhibitor 分子名称: 4-{[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl]sulfanyl}butanamide, GLYCEROL, Heat shock protein HSP 90-alpha, ... 著者 Fukami, T.A, Ono, N. 登録日 2013-08-23 公開日 2014-01-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors Bioorg.Med.Chem., 22, 2014
5X6Q	Crystal structure of Pseudomonas fluorescens KMO in complex with Ro 61-8048 分子名称: 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide, FLAVIN-ADENINE DINUCLEOTIDE, Kynurenine 3-monooxygenase 著者 Kim, H.T, Hwang, K.Y. 登録日 2017-02-23 公開日 2018-02-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.897 Å) 主引用文献 Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase Cell Chem Biol, 25, 2018
1HBO	METHYL-COENZYME M REDUCTASE MCR-RED1-SILENT 分子名称: 1-THIOETHANESULFONIC ACID, CHLORIDE ION, Coenzyme B, ... 著者 Grabarse, W. 登録日 2001-04-20 公開日 2001-08-16 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 On the Mechanism of Biological Methane Formation: Structural Evidence for Conformational Changes in Methyl-Coenzyme M Reductase Upon Substrate Binding J.Mol.Biol., 309, 2001
5X9U	Crystal structure of group III chaperonin in the open state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Thermosome, alpha subunit 著者 An, Y.J, Cha, S.S. 登録日 2017-03-09 公開日 2017-10-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (4.001 Å) 主引用文献 Structural and mechanistic characterization of an archaeal-like chaperonin from a thermophilic bacterium Nat Commun, 8, 2017
5VB8	Crystal structure of the NavAb voltage-gated sodium channel in an open state 分子名称: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, SODIUM ION, ... 著者 Lenaeus, M.J, Catterall, W.A. 登録日 2017-03-28 公開日 2017-04-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structures of closed and open states of a voltage-gated sodium channel. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5Z7B	Crystal structure of the VanR transcription factor in complex with vanillate 分子名称: 4-HYDROXY-3-METHOXYBENZOATE, PadR family transcriptional regulator 著者 Kwak, Y.M, Park, S.C, Yoon, S.I. 登録日 2018-01-28 公開日 2018-08-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of the VanR transcription factor and the role of its unique alpha-helix in effector recognition. FEBS J., 285, 2018
1HBM	METHYL-COENZYME M REDUCTASE ENZYME PRODUCT COMPLEX 分子名称: CHLORIDE ION, FACTOR 430, GLYCEROL, ... 著者 Ermler, U, Grabarse, W. 登録日 2001-04-20 公開日 2001-08-16 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 On the Mechanism of Biological Methane Formation: Structural Evidence for Conformational Changes in Methyl-Coenzyme M Reductase Upon Substrate Binding J.Mol.Biol., 309, 2001
5ZC1	X-ray diffraction analysis of the CsStefin-1 分子名称: Cystatin-1 著者 Jang, S.B, Park, S.Y. 登録日 2018-02-14 公開日 2018-12-26 実験手法 X-RAY DIFFRACTION (2.302708 Å) 主引用文献 Structural basis of the cystein protease inhibitor Clonorchis sinensis Stefin-1. Biochem. Biophys. Res. Commun., 498, 2018
7YS7	RET oncogene primer G4-DNA in 100mMNa+ 分子名称: DNA (5'-D(*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3') 著者 Yin, S, Cao, C. 登録日 2022-08-11 公開日 2023-09-06 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 RET oncogene primer G-quadruplex in Na+ To Be Published
6T3Q	Thrombin in Complex with a D-Phe-Pro-2-aminopyridine derivative 分子名称: (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[(2-azanylpyridin-4-yl)methyl]pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Ngo, K, Collins, C, Heine, A, Klebe, G. 登録日 2019-10-11 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins? J.Med.Chem., 63, 2020
6TDT	Thrombin in Complex with a D-DiPhe-Pro-p-pyridine derivative 分子名称: (2~{S})-1-[(2~{R})-2-azanyl-3,3-diphenyl-propanoyl]-~{N}-(pyridin-4-ylmethyl)pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... 著者 Ngo, K, Heine, A, Klebe, G. 登録日 2019-11-10 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins? J.Med.Chem., 63, 2020
6C96	Cryo-EM structure of mouse TPC1 channel in the apo state 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... 著者 She, J, Guo, J, Chen, Q, Bai, X, Jiang, Y. 登録日 2018-01-25 公開日 2018-04-04 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel. Nature, 556, 2018
8B01	Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Photobacterium profundum in a nanodisc 分子名称: DECANE, DOCOSANE, HEXANE, ... 著者 Davies, J.S, North, R.A, Dobson, R.C.J. 登録日 2022-09-06 公開日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter. Nat Commun, 14, 2023
6BWI	3.7 angstrom cryoEM structure of full length human TRPM4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... 著者 Zhang, J, Li, Z, Duan, J, Li, J, Clapham, D.E. 登録日 2017-12-15 公開日 2018-12-19 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structure of full-length human TRPM4. Proc.Natl.Acad.Sci.USA, 115, 2018
6T4A	Thrombin in Complex with a D-Phe-Pro-p-aminopyridine derivative 分子名称: (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[(6-azanylpyridin-3-yl)methyl]pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Ngo, K, Collins, C, Heine, A, Klebe, G. 登録日 2019-10-13 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins? J.Med.Chem., 63, 2020
5GZW	Crystal structure of AmpC BER adenylylated by acetyl-AMP 分子名称: ADENOSINE MONOPHOSPHATE, Beta-lactamase, SULFATE ION 著者 An, Y.J, Cha, S.S. 登録日 2016-10-02 公開日 2017-10-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.489 Å) 主引用文献 Structural and mechanistic insights into the inhibition of class C beta-lactamases through the adenylylation of the nucleophilic serine. J.Antimicrob.Chemother., 72, 2017
7CIN	Crystal structure of the extended-spectrum class C beta-lactamase AmpC BER with the ordered R2 loop 分子名称: Beta-lactamase, SULFATE ION 著者 Jeong, B.G, Cha, S.S. 登録日 2020-07-07 公開日 2021-05-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.79006362 Å) 主引用文献 Crystal structure of AmpC BER and molecular docking lead to the discovery of broad inhibition activities of halisulfates against beta-lactamases. Comput Struct Biotechnol J, 19, 2021
8CJQ	JzTx-34 toxin peptide E20A mutant 分子名称: Mu-theraphotoxin-Cg1a 著者 Landon, C, Meudal, H. 登録日 2023-02-13 公開日 2023-07-26 実験手法 SOLUTION NMR 主引用文献 Structure-function relationship of new peptides activating human Na v 1.1. Biomed Pharmacother, 165, 2023
8CJR	JzTx-34 toxin peptide W25A mutant 分子名称: Mu-theraphotoxin-Cg1a 著者 Landon, C, Meudal, H. 登録日 2023-02-13 公開日 2023-07-26 実験手法 SOLUTION NMR 主引用文献 Structure-function relationship of new peptides activating human Na v 1.1. Biomed Pharmacother, 165, 2023
8CJT	JzTx-34 toxin peptide W33A mutant 分子名称: Mu-theraphotoxin-Cg1a 著者 Landon, C, Meudal, H. 登録日 2023-02-13 公開日 2023-07-26 実験手法 SOLUTION NMR 主引用文献 Structure-function relationship of new peptides activating human Na v 1.1. Biomed Pharmacother, 165, 2023
7CYB	Saimiri boliviensis boliviensis galectin-13 with glycerol 分子名称: GLYCEROL, Galectin 著者 Su, J. 登録日 2020-09-03 公開日 2021-06-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Actin binding to galectin-13/placental protein-13 occurs independently of the galectin canonical ligand-binding site. Glycobiology, 31, 2021
7CYA	Saimiri boliviensis boliviensis galectin-13 with lactose 分子名称: Galectin, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose 著者 Su, J. 登録日 2020-09-03 公開日 2021-06-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Actin binding to galectin-13/placental protein-13 occurs independently of the galectin canonical ligand-binding site. Glycobiology, 31, 2021
7EGK	Bicarbonate transporter complex SbtA-SbtB bound to AMP 分子名称: ADENOSINE MONOPHOSPHATE, Membrane-associated protein SbtB, SODIUM ION, ... 著者 Fang, S, Huang, X, Zhang, X, Zhang, P. 登録日 2021-03-24 公開日 2021-05-26 最終更新日 2021-06-16 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Molecular mechanism underlying transport and allosteric inhibition of bicarbonate transporter SbtA. Proc.Natl.Acad.Sci.USA, 118, 2021
7EGL	Bicarbonate transporter complex SbtA-SbtB bound to HCO3- 分子名称: BICARBONATE ION, Membrane-associated protein SbtB, SODIUM ION, ... 著者 Fang, S, Huang, X, Zhang, X, Zhang, P. 登録日 2021-03-24 公開日 2021-05-26 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Molecular mechanism underlying transport and allosteric inhibition of bicarbonate transporter SbtA. Proc.Natl.Acad.Sci.USA, 118, 2021
8DJ1	Crystal structure of NavAb V126T as a basis for the human Nav1.7 Inherited Erythromelalgia S241T mutation 分子名称: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein 著者 Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. 登録日 2022-06-29 公開日 2023-04-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7. Proc.Natl.Acad.Sci.USA, 120, 2023

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