4BUD
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![BU of 4bud by Molmil](/molmil-images/mine/4bud) | Crystal structure of human tankyrase 2 in complex with 2-(4-tert- butylphenyl)-1,4-dihydroquinazolin-4-one | 分子名称: | 2-(4-tert-butylphenyl)-1,4-dihydroquinazolin-4-one, GLYCEROL, SULFATE ION, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-20 | 公開日 | 2013-10-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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7ZES
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![BU of 7zes by Molmil](/molmil-images/mine/7zes) | Human SLFN11 dimer bound to ssDNA | 分子名称: | DNA (5'-D(P*CP*GP*CP*GP*T)-3'), MAGNESIUM ION, Schlafen family member 11, ... | 著者 | Metzner, F.J, Kugler, M, Wenzl, S.J, Lammens, K. | 登録日 | 2022-03-31 | 公開日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanistic understanding of human SLFN11. Nat Commun, 13, 2022
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7ZEL
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![BU of 7zel by Molmil](/molmil-images/mine/7zel) | Human SLFN11 dimer apoenzyme | 分子名称: | MAGNESIUM ION, Schlafen family member 11, ZINC ION | 著者 | Metzner, F.J, Kugler, M, Wenzl, S.J, Lammens, K. | 登録日 | 2022-03-31 | 公開日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanistic understanding of human SLFN11. Nat Commun, 13, 2022
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7ZEP
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![BU of 7zep by Molmil](/molmil-images/mine/7zep) | Human SLFN11 E209A dimer | 分子名称: | Schlafen family member 11, ZINC ION | 著者 | Metzner, F.J, Kugler, M, Wenzl, S.J, Lammens, K. | 登録日 | 2022-03-31 | 公開日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanistic understanding of human SLFN11. Nat Commun, 13, 2022
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8AGT
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![BU of 8agt by Molmil](/molmil-images/mine/8agt) | Yeast RQC complex in state F | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Tesina, P, Buschauer, R, Beckmann, R. | 登録日 | 2022-07-20 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol.Cell, 83, 2023
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8AGZ
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![BU of 8agz by Molmil](/molmil-images/mine/8agz) | Yeast RQC complex in state with the RING domain of Ltn1 in the OUT position | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Tesina, P, Buschauer, R, Beckmann, R. | 登録日 | 2022-07-20 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol.Cell, 83, 2023
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8AGX
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![BU of 8agx by Molmil](/molmil-images/mine/8agx) | Yeast RQC complex in state with the RING domain of Ltn1 in the IN position | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Tesina, P, Buschauer, R, Beckmann, R. | 登録日 | 2022-07-20 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol.Cell, 83, 2023
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8AGV
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![BU of 8agv by Molmil](/molmil-images/mine/8agv) | Yeast RQC complex in state H | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Tesina, P, Buschauer, R, Beckmann, R. | 登録日 | 2022-07-20 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol.Cell, 83, 2023
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8AAF
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![BU of 8aaf by Molmil](/molmil-images/mine/8aaf) | Yeast RQC complex in state G | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Tesina, P, Buschauer, R, Beckmann, R. | 登録日 | 2022-07-01 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol.Cell, 83, 2023
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8AGU
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![BU of 8agu by Molmil](/molmil-images/mine/8agu) | Yeast RQC complex in state E | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Tesina, P, Buschauer, R, Beckmann, R. | 登録日 | 2022-07-20 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol.Cell, 83, 2023
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4BUI
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![BU of 4bui by Molmil](/molmil-images/mine/4bui) | Crystal structure of human tankyrase 2 in complex with methyl 4-(4- oxo-3,4-dihydroquinazolin-2-yl)benzoate | 分子名称: | GLYCEROL, METHYL 4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)BENZOATE, SULFATE ION, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-20 | 公開日 | 2013-10-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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4BU8
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![BU of 4bu8 by Molmil](/molmil-images/mine/4bu8) | Crystal structure of human tankyrase 2 in complex with 4-(4-oxo-1,4- dihydroquinazolin-2-yl)benzonitrile | 分子名称: | 4-(4-OXO-1,4-DIHYDROQUINAZOLIN-2-YL)BENZONITRILE, GLYCEROL, SULFATE ION, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-20 | 公開日 | 2013-10-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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4BUX
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![BU of 4bux by Molmil](/molmil-images/mine/4bux) | Crystal structure of human tankyrase 2 in complex with 3-((4-(4-oxo-3, 4-dihydroquinazolin-2-yl)phenyl)methyl)imidazolidine-2,4-dione | 分子名称: | 3-[[4-(4-oxidanylidene-3H-quinazolin-2-yl)phenyl]methyl]imidazolidine-2,4-dione, GLYCEROL, SULFATE ION, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-24 | 公開日 | 2013-10-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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8AGW
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![BU of 8agw by Molmil](/molmil-images/mine/8agw) | Yeast RQC complex in state D | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Tesina, P, Buschauer, R, Beckmann, R. | 登録日 | 2022-07-20 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol.Cell, 83, 2023
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8AV9
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![BU of 8av9 by Molmil](/molmil-images/mine/8av9) | INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH COMPOUND 1 | 分子名称: | (3R,6R,7S,8E,11S,12R,22S)-6'-chloro-7-methoxy-11,12-dimethyl-13,13-dioxo-spiro[20-oxa-13-gamma6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene-22,1'-tetralin]-15-one, Fab Heavy Chain, Fab Light Chain, ... | 著者 | Hargreaves, D. | 登録日 | 2022-08-26 | 公開日 | 2023-05-24 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1. Proc.Natl.Acad.Sci.USA, 120, 2023
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4DBW
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![BU of 4dbw by Molmil](/molmil-images/mine/4dbw) | Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 2'-desmethyl-indomethacin | 分子名称: | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl]acetic acid | 著者 | Chen, M, Christianson, D.W, Marnett, L.J, Penning, T.M. | 登録日 | 2012-01-16 | 公開日 | 2013-03-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17 beta-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. J.Med.Chem., 56, 2013
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4GQ3
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![BU of 4gq3 by Molmil](/molmil-images/mine/4gq3) | Human menin with bound inhibitor MI-2 | 分子名称: | 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine, DI(HYDROXYETHYL)ETHER, Menin, ... | 著者 | Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T. | 登録日 | 2012-08-22 | 公開日 | 2012-09-19 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120, 2012
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4BUA
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![BU of 4bua by Molmil](/molmil-images/mine/4bua) | Crystal structure of human tankyrase 2 in complex with 2-(4-(methylsulfanyl)phenyl)-3,4-dihydroquinazolin-4-one | 分子名称: | 2-(4-methylsulfanylphenyl)-3H-quinazolin-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-20 | 公開日 | 2013-10-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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4BUS
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![BU of 4bus by Molmil](/molmil-images/mine/4bus) | Crystal structure of human tankyrase 2 in complex with 2-(4-(4-oxo-3, 4-dihydroquinazolin-2-yl)phenoxy)acetic acid | 分子名称: | 2-[4-(4-oxidanylidene-3H-quinazolin-2-yl)phenoxy]ethanoic acid, GLYCEROL, SULFATE ION, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-24 | 公開日 | 2013-10-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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4BUF
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![BU of 4buf by Molmil](/molmil-images/mine/4buf) | Crystal structure of human tankyrase 2 in complex with 2-(4- acetylphenyl)-3,4-dihydroquinazolin-4-one | 分子名称: | 2-(4-acetylphenyl)-3,4-dihydroquinazolin-4-one, GLYCEROL, SULFATE ION, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-20 | 公開日 | 2013-10-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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4BUW
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![BU of 4buw by Molmil](/molmil-images/mine/4buw) | Crystal structure of human tankyrase 2 in complex with 2-(4-(2-oxo-1, 3-oxazolidin-3-yl)phenyl)-3,4-dihydroquinazolin-4-one | 分子名称: | 2-[4-(2-OXO-1,3-OXAZOLIDIN-3-YL)PHENYL]-3,4-DIHYDROQUINAZOLIN-4-ONE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-24 | 公開日 | 2013-10-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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2X0U
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![BU of 2x0u by Molmil](/molmil-images/mine/2x0u) | STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold | 分子名称: | 6,7-DIHYDRO[1,4]DIOXINO[2,3-F][1,3]BENZOTHIAZOL-2-AMINE, CELLULAR TUMOR ANTIGEN P53, ZINC ION | 著者 | Joerger, A.C, Kaar, J.L, Basse, N, Fersht, A.R. | 登録日 | 2009-12-17 | 公開日 | 2010-01-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant. Chem.Biol., 17, 2010
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4EOY
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![BU of 4eoy by Molmil](/molmil-images/mine/4eoy) | |
4DBU
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![BU of 4dbu by Molmil](/molmil-images/mine/4dbu) | Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3-((4 -(trifluoromethyl)phenyl)amino)benzoic acid | 分子名称: | 3-{[4-(trifluoromethyl)phenyl]amino}benzoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Chen, M, Christianson, D.W, Winkler, J.D, Penning, T.M. | 登録日 | 2012-01-16 | 公開日 | 2012-03-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.528 Å) | 主引用文献 | Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer. Bioorg.Med.Chem.Lett., 22, 2012
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8BAH
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![BU of 8bah by Molmil](/molmil-images/mine/8bah) | Human Mre11-Nbs1 complex | 分子名称: | Double-strand break repair protein MRE11, MANGANESE (II) ION, Nibrin | 著者 | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | 登録日 | 2022-10-11 | 公開日 | 2023-01-11 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (4.13 Å) | 主引用文献 | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
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