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4BUX

Crystal structure of human tankyrase 2 in complex with 3-((4-(4-oxo-3, 4-dihydroquinazolin-2-yl)phenyl)methyl)imidazolidine-2,4-dione

Summary for 4BUX
Entry DOI10.2210/pdb4bux/pdb
Related4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUY
DescriptorTANKYRASE-2, ZINC ION, GLYCEROL, ... (6 entities in total)
Functional Keywordstransferase, protein-ligand complex, diphtheria toxin like fold, adp-ribosylation, transferase-transferase inhibitor complex
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total formula weight55875.35
Authors
Haikarainen, T.,Narwal, M.,Lehtio, L. (deposition date: 2013-06-24, release date: 2013-10-30, Last modification date: 2023-12-20)
Primary citationHaikarainen, T.,Koivunen, J.,Narwal, M.,Venkannagari, H.,Obaji, E.,Joensuu, P.,Pihlajaniemi, T.,Lehtio, L.
Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors.
Chemmedchem, 8:1978-, 2013
Cited by
PubMed: 24130191
DOI: 10.1002/CMDC.201300337
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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