PDB: 1349 件ウェブページステータス検索Chemie searchBIRD

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4HEZ	Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure 分子名称: 1-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION 著者 Aggarwal, M, McKenna, R. 登録日 2012-10-04 公開日 2013-10-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.3446 Å) 主引用文献 Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. IUCrJ, 1, 2014
4JSW	Human carbonic anhydrase II H94C 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Martin, D.P, Hann, Z.S, Cohen, S.M. 登録日 2013-03-22 公開日 2013-06-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site. Inorg.Chem., 52, 2013
4JSS	Human carbonic anhydrase II H94D bound to a bidentate inhibitor 分子名称: 1-hydroxy-2-sulfanylpyridinium, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... 著者 Martin, D.P, Hann, Z.S, Cohen, S.M. 登録日 2013-03-22 公開日 2013-06-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site. Inorg.Chem., 52, 2013
4JSZ	Benzenesulfonamide bound to hCAII H94C 分子名称: Carbonic anhydrase 2, ZINC ION, benzenesulfonamide 著者 Martin, D.P, Hann, Z.S, Cohen, S.M. 登録日 2013-03-22 公開日 2013-06-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site. Inorg.Chem., 52, 2013
4JS6	Crystal structure of inhibitor-free hCAII H94D 分子名称: Carbonic anhydrase 2, MERCURIBENZOIC ACID, ZINC ION 著者 Martin, D.P, Hann, Z.S, Cohen, S.M. 登録日 2013-03-22 公開日 2013-06-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site. Inorg.Chem., 52, 2013
4ITO	Human CA II inhibition by novel sulfonamide 分子名称: 4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDE, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Aggarwal, M, McKenna, R. 登録日 2013-01-18 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.162 Å) 主引用文献 Human CA II inhibition by novel sulfonamide To be Published
4JSA	Benzenesulfonamide complexed with hCAII H94D 分子名称: Carbonic anhydrase 2, MERCURIBENZOIC ACID, SULFATE ION, ... 著者 Martin, D.P, Hann, Z.S, Cohen, S.M. 登録日 2013-03-22 公開日 2013-06-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site. Inorg.Chem., 52, 2013
4IDR	Human Carbonic Anhydrase II Proton Transfer Double Mutant 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 Mikulski, R.M, West, D.M. 登録日 2012-12-13 公開日 2012-12-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase II. Biochemistry, 52, 2013
4FU5	Carbonic Anhydrase II in complex with N-[(2Z)-1,3-oxazolidin-2-ylidene]sulfuric diamide 分子名称: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, MERCURIBENZOIC ACID, ... 著者 Di Pizio, A, Heine, A, Klebe, G. 登録日 2012-06-28 公開日 2013-07-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (0.98 Å) 主引用文献 HIgh resolution crystal structures of Carbonic Anhzdrase II in complex with nonvel sulfamide binders To be Published
4K0Z	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with methazolamide 分子名称: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ... 著者 Biswas, S, McKenna, R. 登録日 2013-04-04 公開日 2014-04-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Developing isoform specific inhibitors for hCAIX using CAIX mimic To be Published
4KP8	Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with 3-[(Pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide 分子名称: 1,2-ETHANEDIOL, 3-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide, Carbonic anhydrase 12, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2013-05-13 公開日 2013-11-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII Bioorg.Med.Chem., 21, 2013
4K13	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with dorzolamide 分子名称: (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Biswas, S, McKenna, R. 登録日 2013-04-04 公開日 2014-04-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Developing isoform specific inhibitors for hCAIX using CAIX mimic To be Published
4K1Q	Structure of hCAIX mimic (hCAII with 5 mutations in active site) 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Biswas, S, McKenna, R. 登録日 2013-04-05 公開日 2014-04-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Developing isoform specific inhibitors for hCAIX using CAIX mimic To be Published
4KNI	Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide, Carbonic anhydrase 2, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2013-05-10 公開日 2013-11-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII Bioorg.Med.Chem., 21, 2013
4K0T	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide 分子名称: 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Biswas, S, McKenna, R. 登録日 2013-04-04 公開日 2014-04-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Designing isoform specific inhibitors against hCAIX using CAIX mimic To be Published
4K0S	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with acetazolamide 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, ZINC ION 著者 Biswas, S, McKenna, R. 登録日 2013-04-04 公開日 2014-04-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 Developing isoform specific inhibitors against hCAIX using CAIX mimic To be Published
1CAI	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION 著者 Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. 登録日 1992-09-17 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CCS	STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-12-09 公開日 1995-02-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proc.Natl.Acad.Sci.USA, 92, 1995
1BN4	CARBONIC ANHYDRASE II INHIBITOR 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, N-[(4-METHOXYPHENYL)METHYL]2,5-THIOPHENEDESULFONAMIDE, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-31 公開日 1999-05-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BN1	CARBONIC ANHYDRASE II INHIBITOR 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE), ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-31 公開日 1999-05-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNQ	CARBONIC ANHYDRASE II INHIBITOR 分子名称: (R)-4-ETHYLAMINO-3,4-DIHYDRO-2-(2-METHOYLETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-06-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNV	CARBONIC ANHYDRASE II INHIBITOR 分子名称: (S)-3,4-DIHYDRO-2-(3-METHOXYPHENYL)-4-METHYLAMINO-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-02-16 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1CVD	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-06-21 公開日 1994-12-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1CVH	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-11-16 公開日 1995-02-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1CNB	COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES 分子名称: BETA-MERCAPTOETHANOL, CARBONIC ANHYDRASE II 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-06-13 公開日 1994-10-15 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994

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