4KNI

Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide

Summary for 4KNI

Entry DOI	10.2210/pdb4kni/pdb
Related	4KNJ 4KNM 4KNN 4KP5 4KP8
Descriptor	Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	30077.84
Authors	Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2013-05-10, release date: 2013-11-06, Last modification date: 2023-11-08)
Primary citation	Capkauskaite, E.,Zubriene, A.,Smirnov, A.,Torresan, J.,Kisonaite, M.,Kazokaite, J.,Gylyte, J.,Michailoviene, V.,Jogaite, V.,Manakova, E.,Grazulis, S.,Tumkevicius, S.,Matulis, D. Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII Bioorg.Med.Chem., 21:6937-6947, 2013 Cited by PubMed: 24103428 DOI: 10.1016/j.bmc.2013.09.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation