8RX0
 
 | | (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub | | 分子名称: | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, Elongin-B, ... | | 著者 | Crowe, C, Nakasone, M.A. | | 登録日 | 2024-02-05 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub
To Be Published
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8RWZ
 | | Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL | | 分子名称: | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Cullin-2, ... | | 著者 | Ciulli, A, Crowe, C, Nakacone, M.A. | | 登録日 | 2024-02-05 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL
To Be Published
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8WQE
 | | Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 1) | | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | | 著者 | Chen, X, Zhang, K, Xu, C. | | 登録日 | 2023-10-11 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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8WQH
 | | cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) | | 分子名称: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Chen, X, Zhang, K, Xu, C. | | 登録日 | 2023-10-11 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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8WQF
 | | cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2) | | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | | 著者 | Chen, X, Zhang, K, Xu, C. | | 登録日 | 2023-10-11 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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8WQC
 | | cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1 | | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | | 著者 | Chen, X, Zhang, K, Xu, C. | | 登録日 | 2023-10-11 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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8GQ6
 | | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Sun, L, Chen, Z, Hu, Y, Mao, Q. | | 登録日 | 2022-08-29 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H3F
 | | Cryo-EM Structure of the KBTBD2-CRL3-CSN complex | | 分子名称: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (6.73 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H3Q
 | | Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex | | 分子名称: | Cullin-3, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-09 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H3A
 | | Cryo-EM Structure of the KBTBD2-CRL3~N8(removed)-CSN complex | | 分子名称: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (7.51 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H36
 | | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H34
 | | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 hexameric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-07 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (7.99 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H3R
 | | Cryo-EM Structure of the KBTBD2-CRL3~N8 dimeric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-09 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (6.36 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H33
 | | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-07 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (7.86 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H35
 | | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 octameric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (7.41 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H38
 | | Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex | | 分子名称: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H37
 | | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (7.52 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8IJ1
 | | Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | | 著者 | Dai, Z, Liang, L, Yin, Y.X. | | 登録日 | 2023-02-24 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
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8JAR
 | | Structure of CRL2APPBP2 bound with RxxGPAA degron (dimer) | | 分子名称: | Amyloid protein-binding protein 2, Cullin-2, Elongin-B, ... | | 著者 | Zhao, S, Zhang, K, Xu, C. | | 登録日 | 2023-05-07 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8JAQ
 | | Structure of CRL2APPBP2 bound with RxxGP degron (tetramer) | | 分子名称: | Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Zhao, S, Zhang, K, Xu, C. | | 登録日 | 2023-05-06 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8JAU
 | | Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (dimer) | | 分子名称: | Amyloid protein-binding protein 2, Cullin-2, Elongin-B, ... | | 著者 | Zhao, S, Zhang, K, Xu, C. | | 登録日 | 2023-05-07 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8JAL
 | | Structure of CRL2APPBP2 bound with RxxGP degron (dimer) | | 分子名称: | Amyloid protein-binding protein 2, Cullin-2, Elongin-B, ... | | 著者 | Zhao, S, Zhang, K, Xu, C. | | 登録日 | 2023-05-06 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8JAV
 | | Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (tetramer) | | 分子名称: | Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Zhao, S, Zhang, K, Xu, C. | | 登録日 | 2023-05-07 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8JAS
 | | Structure of CRL2APPBP2 bound with RxxGPAA degron (tetramer) | | 分子名称: | Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Zhao, S, Zhang, K, Xu, C. | | 登録日 | 2023-05-07 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8JE1
 | | An asymmetry dimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complexed with BEX2 | | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | | 著者 | Dai, Z, Liang, L, Yin, Y.X. | | 登録日 | 2023-05-15 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
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