7KF7
 
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3AOC
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3AOA
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4CDI
 | | Crystal structure of AcrB-AcrZ complex | | 分子名称: | ACRIFLAVINE RESISTANCE PROTEIN B, PREDICTED PROTEIN | | 著者 | Du, D, James, N, Klimont, E, Luisi, B.F. | | 登録日 | 2013-10-31 | | 公開日 | 2014-04-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structure of the Acrab-Tolc Multidrug Efflux Pump.
Nature, 509, 2014
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4DX7
 | | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop | | 分子名称: | Acriflavine resistance protein B, DARPIN, DECANE, ... | | 著者 | Eicher, T, Cha, H, Seeger, M.A, Brandstaetter, L, El-Delik, J, Bohnert, J.A, Kern, W.V, Verrey, F, Gruetter, M.G, Diederichs, K, Pos, K.M. | | 登録日 | 2012-02-27 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.253 Å) | | 主引用文献 | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
Proc.Natl.Acad.Sci.USA, 109, 2012
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6Q4O
 | | Fusidic acid bound AcrB_I27A | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, DARPIN, DECANE, ... | | 著者 | Tam, H.K, Pos, K.M. | | 登録日 | 2018-12-06 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB.
J.Mol.Biol., 432, 2020
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6Q4P
 | | Fusidic acid bound AcrB_N298A | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, CHLORIDE ION, ... | | 著者 | Tam, H.K, Pos, K.M. | | 登録日 | 2018-12-06 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB.
J.Mol.Biol., 432, 2020
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6Q4N
 | | Fusidic acid bound AcrB_V340A | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, DARPin, DECANE, ... | | 著者 | Tam, H.K, Pos, K.M. | | 登録日 | 2018-12-06 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB.
J.Mol.Biol., 432, 2020
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7CZ9
 | | Crystal structure of multidrug efflux transporter OqxB from Klebsiella pneumoniae | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter, GLYCEROL, ... | | 著者 | Murakami, S, Okada, U, Yamashita, E. | | 登録日 | 2020-09-07 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae.
Nat Commun, 12, 2021
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7B8S
 | | Fusidic acid bound structure of bacterial efflux pump. | | 分子名称: | DARPin, FUSIDIC ACID, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | | 登録日 | 2020-12-13 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.
Nat Commun, 12, 2021
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7B8T
 | | Levofloxacin bound structure of bacterial efflux pump. | | 分子名称: | (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | | 登録日 | 2020-12-13 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.
Nat Commun, 12, 2021
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7B8R
 | | Doxycycline bound structure of bacterial efflux pump. | | 分子名称: | (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, DARPin, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | | 登録日 | 2020-12-13 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.
Nat Commun, 12, 2021
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1OY6
 | | Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump | | 分子名称: | Acriflavine resistance protein B | | 著者 | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | | 登録日 | 2003-04-03 | | 公開日 | 2003-05-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.68 Å) | | 主引用文献 | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
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1OY8
 | | Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump | | 分子名称: | Acriflavine resistance protein B, RHODAMINE 6G | | 著者 | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | | 登録日 | 2003-04-03 | | 公開日 | 2003-05-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.63 Å) | | 主引用文献 | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
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6SGU
 | | Cryo-EM structure of Escherichia coli AcrB and DARPin in Saposin A-nanodisc | | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB | | 著者 | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | | 登録日 | 2019-08-05 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment.
Structure, 28, 2020
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7B5P
 | | AcrB in cycloalkane amphipol | | 分子名称: | Efflux pump membrane transporter | | 著者 | Higgins, A.J, Flynn, A.J, Muench, S.P. | | 登録日 | 2020-12-05 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis.
Commun Biol, 4, 2021
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1OYE
 | | Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump | | 分子名称: | 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, Acriflavine resistance protein B | | 著者 | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | | 登録日 | 2003-04-03 | | 公開日 | 2003-05-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.48 Å) | | 主引用文献 | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
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1OY9
 | | Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump | | 分子名称: | Acriflavine resistance protein B, ETHIDIUM | | 著者 | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | | 登録日 | 2003-04-03 | | 公開日 | 2003-05-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
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1OYD
 | | Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump | | 分子名称: | Acriflavine resistance protein B, DEQUALINIUM | | 著者 | Yu, E.W, MeDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | | 登録日 | 2003-04-03 | | 公開日 | 2003-05-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Science, 300, 2003
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6SGT
 | | Cryo-EM structure of Escherichia coli AcrB and DARPin in Saposin A-nanodisc with cardiolipin | | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB | | 著者 | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | | 登録日 | 2019-08-05 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | | 主引用文献 | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment.
Structure, 28, 2020
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7O3N
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7O3M
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7O3L
 | | Crystal Structure of AcrB Double Mutant | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter | | 著者 | Ababou, A. | | 登録日 | 2021-04-02 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.526 Å) | | 主引用文献 | Crystal Structure of AcrB Double Mutant
To Be Published
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1T9U
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1T9T
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